Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-
![Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]- price.](/CAS/GIF/217645-70-0.gif)
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- $17 - $3791
- Product name: Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-
- CAS: 217645-70-0
- MF: C21H24ClFN4O3
- MW: 434.89
- EINECS:
- MDL Number:MFCD09859709
- Synonyms:Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-;(5-Chloro-2-{2-[4-(4-fluoro-benzyl)-2-Methyl-piperazin-1-yl]-2-oxo-ethoxy}-phenyl)-urea;ZK811752 (BX471);(2R)-1-[[2-[(Aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methylpiperazine ZK811752 (BX471);N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea;BX471(ZK-811752);Piperazine,1-[[2-[(aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methyl-, (2R)-;(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine
70 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- TCI Chemical
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO
- 1mg
- 10mM(1mLinDMSO)
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA00BEZU
- Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98%
- Packaging1mg
- Price$17
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BEZU
- Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine ≥98%(HPLC)
- Packaging5mg
- Price$27
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BEZU
- Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine ≥98%(HPLC)
- Packaging10mg
- Price$48
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BEZU
- Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98%
- Packaging25mg
- Price$87
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BEZU
- Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98%
- Packaging50mg
- Price$147
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BEZU
- Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98%
- Packaging100mg
- Price$263
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BEZU
- Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98%
- Packaging250mg
- Price$441
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BEZU
- Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98%
- Packaging1g
- Price$1682
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72364
- Product descriptionZK-811752 98%
- Packaging1G
- Price$900
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72364
- Product descriptionZK-811752 98%
- Packaging1G
- Price$900
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72364
- Product descriptionZK-811752 98%
- Packaging100MG
- Price$180
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72364
- Product descriptionZK-811752 98%
- Packaging100MG
- Price$180
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3511AH
- Product description1-(2-(2-((R)-4-(4-Fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenyl)urea
- Packaging250mg
- Price$421
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA434794
- Product descriptionBX 471 98+%
- Packaging5mg
- Price$222
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA434794
- Product descriptionBX 471 98+%
- Packaging10mg
- Price$333
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA434794
- Product descriptionBX 471 98+%
- Packaging25mg
- Price$566
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00BEZU | (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98% | 1mg | $17 | 2026-05-28 | Buy |
| aablocks | AA00BEZU | (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine ≥98%(HPLC) | 5mg | $27 | 2026-05-28 | Buy |
| aablocks | AA00BEZU | (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine ≥98%(HPLC) | 10mg | $48 | 2026-05-28 | Buy |
| aablocks | AA00BEZU | (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98% | 25mg | $87 | 2026-05-28 | Buy |
| aablocks | AA00BEZU | (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98% | 50mg | $147 | 2026-05-28 | Buy |
| aablocks | AA00BEZU | (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98% | 100mg | $263 | 2026-05-28 | Buy |
| aablocks | AA00BEZU | (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98% | 250mg | $441 | 2026-05-28 | Buy |
| aablocks | AA00BEZU | (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98% | 1g | $1682 | 2026-05-28 | Buy |
| ACHEMBLOCK | S72364 | ZK-811752 98% | 1G | $900 | 2026-05-25 | Buy |
| ACHEMBLOCK | S72364 | ZK-811752 98% | 1G | $900 | 2026-05-27 | Buy |
| ACHEMBLOCK | S72364 | ZK-811752 98% | 100MG | $180 | 2026-05-25 | Buy |
| ACHEMBLOCK | S72364 | ZK-811752 98% | 100MG | $180 | 2026-05-27 | Buy |
| AK Scientific | 3511AH | 1-(2-(2-((R)-4-(4-Fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenyl)urea | 250mg | $421 | 2021-12-16 | Buy |
| Ambeed | A434794 | BX 471 98+% | 5mg | $222 | 2021-12-16 | Buy |
| Ambeed | A434794 | BX 471 98+% | 10mg | $333 | 2021-12-16 | Buy |
| Ambeed | A434794 | BX 471 98+% | 25mg | $566 | 2021-12-16 | Buy |
Properties
Boiling point :593.5±50.0 °C(Predicted)
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,2-8°C
solubility :DMSO: ≥25mg/mL
pka :13.66±0.70(Predicted)
form :White powder
color :white to tan
InChI :1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1
InChIKey :XQYASZNUFDVMFH-CQSZACIVSA-N
SMILES :N(C1=CC(Cl)=CC=C1OCC(N1CCN(CC2=CC=C(F)C=C2)C[C@H]1C)=O)C(N)=O
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,2-8°C
solubility :DMSO: ≥25mg/mL
pka :13.66±0.70(Predicted)
form :White powder
color :white to tan
InChI :1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1
InChIKey :XQYASZNUFDVMFH-CQSZACIVSA-N
SMILES :N(C1=CC(Cl)=CC=C1OCC(N1CCN(CC2=CC=C(F)C=C2)C[C@H]1C)=O)C(N)=O
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||||||||||||||||
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Description
The CC chemokine receptor-1 (CCR1), whose ligands include macrophage inflammatory protein-1α (MIP-1α), RANTES, and monocyte chemotactic protein-3 (MCP-3), has a central role in leukocyte trafficking and is highly expressed in certain autoimmune diseases. BX 471 is a nonpeptide CCR1 antagonist that has been shown to displace MIP-1α, RANTES, and MCP-3 with Ki values of 1, 2.8, and 5.5 nM, respectively. It demonstrates >10,000-fold selectivity for CCR1 over 28 additional G protein-coupled receptors, including related chemokine receptors. In a rat experimental allergic encephalomyelitis model of multiple sclerosis, BX 471 at 50 mg/kg was shown to significantly reduce the severity of the disease. BX 471 also decreases the inflammatory response during sepsis, blocks migration of monocytes isolated from rheumatoid arthritis patients, and prevents macrophage and T-cell recruitment in a mouse model of lupus nephritis.Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
Chemia Biotechnology（Shanghai） Co., Ltd
BOC Sciences
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
ShenZhen Trendseen Biological Technology Co.,Ltd.
Zibo Hangyu Biotechnology Development Co., Ltd
Aladdin Scientific
