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ChemicalBook >> CAS DataBase List >> 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile

4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile

$12 - $2194.5
Product name: 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile
CAS: 500287-72-9
MF: C22H18N6
MW: 366.42
EINECS:
MDL Number:MFCD11046372
Synonyms:4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile;4-[[4-[[4-[(E)-2-Cyanovinyl]-2,6-diMethylphenyl]aMino]pyriMidin-2-yl]aMino]benzonitrile;4-{[4-({4-[(1E)-2-cyanoeth-1-en-1-yl]-2,6-diMethylphenyl}aMino)pyriMidin-2-yl]aMino}benzonitrile;Rilpivirine(R 278474;Rilpivirine (R 278474, TMC 278);4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile;R 278474;TMC 278

Price95 Properties Safety Information Description

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Brand

aablocks
ACHEMBLOCK
Adipogen Life Sciences
AK Scientific
Ambeed
American Custom Chemicals Corporation
ApexBio Technology
Arctom
Axon Medchem
Biorbyt Ltd
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
TRC
Usbiological

Package

500mg
1000mg
10mM*1mLinDMSO(Solution)
10mM(in1mLDMSO)
10mM*1mLinDMSO(Solid+Solvent)
2.5mg
100.00g
250.00g
50.00g
10mM*1mLinDMSO
10mM(in 1mL DMSO)
1mg
5mg
10mg
25mg
50mg
100mg
250mg
1g
5g
10g

Manufactureraablocks
Product numberAA00DB4J
Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%
Packaging1mg
Price$17
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00DB4J
Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile ≥98%
Packaging10mg
Price$18
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00DB4J
Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%(HPLC)
Packaging25mg
Price$32
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00DB4J
Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%
Packaging50mg
Price$53
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00DB4J
Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%(HPLC)
Packaging100mg
Price$68
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00DB4J
Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%(HPLC)
Packaging250mg
Price$128
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00DB4J
Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 97%
Packaging1g
Price$296
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00DB4J
Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 97%
Packaging5g
Price$1063
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00DB4J
Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 97%
Packaging10g
Price$1653
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product number10410
Product descriptionRilpivirine 98%
Packaging5G
Price$850
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product number10410
Product descriptionRilpivirine 98%
Packaging1G
Price$240
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product number10410
Product descriptionRilpivirine 98%
Packaging100MG
Price$55
Updated2026-05-27
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ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3750-M005
Product descriptionRilpivirine ≥98%(HPLC)
Packaging5mg
Price$50
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3750-M025
Product descriptionRilpivirine ≥98%(HPLC)
Packaging25mg
Price$200
Updated2021-12-16
Buy

ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3750-M025
Product descriptionRilpivirine ≥98%(HPLC)
Packaging25mg
Price$200
Updated2026-05-06
Buy

ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3750-M100
Product descriptionRilpivirine ≥98%(HPLC)
Packaging100mg
Price$430
Updated2026-05-06
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA00DB4J	4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%	1mg	$17	2026-05-28	Buy
aablocks	AA00DB4J	4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile ≥98%	10mg	$18	2026-05-28	Buy
aablocks	AA00DB4J	4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%(HPLC)	25mg	$32	2026-05-28	Buy
aablocks	AA00DB4J	4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%	50mg	$53	2026-05-28	Buy
aablocks	AA00DB4J	4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%(HPLC)	100mg	$68	2026-05-28	Buy
aablocks	AA00DB4J	4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%(HPLC)	250mg	$128	2026-05-28	Buy
aablocks	AA00DB4J	4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 97%	1g	$296	2026-05-28	Buy
aablocks	AA00DB4J	4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 97%	5g	$1063	2026-05-28	Buy
aablocks	AA00DB4J	4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 97%	10g	$1653	2026-05-28	Buy
ACHEMBLOCK	10410	Rilpivirine 98%	5G	$850	2026-05-27	Buy
ACHEMBLOCK	10410	Rilpivirine 98%	1G	$240	2026-05-27	Buy
ACHEMBLOCK	10410	Rilpivirine 98%	100MG	$55	2026-05-27	Buy
Adipogen Life Sciences	AG-CR1-3750-M005	Rilpivirine ≥98%(HPLC)	5mg	$50	2026-05-06	Buy
Adipogen Life Sciences	AG-CR1-3750-M025	Rilpivirine ≥98%(HPLC)	25mg	$200	2021-12-16	Buy
Adipogen Life Sciences	AG-CR1-3750-M025	Rilpivirine ≥98%(HPLC)	25mg	$200	2026-05-06	Buy
Adipogen Life Sciences	AG-CR1-3750-M100	Rilpivirine ≥98%(HPLC)	100mg	$430	2026-05-06	Buy

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Properties

Melting point :245℃
Boiling point :634.1±65.0 °C(Predicted)
Density :1.27
storage temp. :Refrigerator
solubility :Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Water (Very Slightly)
pka :4.56±0.10(Predicted)
form :Solid
color :Yellow
InChI :InChI=1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+
InChIKey :YIBOMRUWOWDFLG-ONEGZZNKSA-N
SMILES :C(#N)C1=CC=C(NC2=NC=CC(NC3=C(C)C=C(/C=C/C#N)C=C3C)=N2)C=C1

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H400	Very toxic to aquatic life	Hazardous to the aquatic environment, acute hazard	Category 1	Warning	P273, P391, P501
H410	Very toxic to aquatic life with long lasting effects	Hazardous to the aquatic environment, long-term hazard	Category 1	Warning	P273, P391, P501

Precautionary statements:

P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330	Rinse mouth.
P391	Collect spillage. Hazardous to the aquatic environment
P501	Dispose of contents/container to..…

Description

In May 2011, the U.S. FDA approved rilpivirine in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV) 1 infection in treatment-naive adult patients. Rilpivirine is a member of the nonnucleoside reverse transcriptase inhibitor (NNRTI) class of anti-HIV agents. It is highly potent against a range of wild-type HIV strains (EC50=0.07–1.0 nM),～10–20 timesmore potent than the NNRTI efavirenz (Sustiva), and active against HIV strains resistant to other NNRTIs. The discovery of rilpivirine was guided by molecular modeling and X-ray crystallography of HIV-1 RT complexed with inhibitors. The synthesis of rilpivirine is accomplished by an efficient 6-step route in which the key step is coupling of 4-((4-chloropyrimidin-2-yl)amino)benzonitrile with (E)-3-(4-amino-3,5-dimethylphenyl)acrylonitrile.

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Suppliers and manufacturers

Hebei Yanxi Chemical Co., Ltd.

rilpivirine CAS:500287-72-9

Hefei Lbao Physical & Chemical Science Co.,Ltd

(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile CAS:500287-72-9

career henan chemical co

$2.00
4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile CAS:500287-72-9

Capot Chemical Co.,Ltd.

Henan Tianfu Chemical Co.,Ltd.

Nanjing ChemLin Chemical Industry Co., Ltd.

ATK CHEMICAL COMPANY LIMITED

Shaanxi Yikanglong Biotechnology Co., Ltd.

Biochempartner

BOC Sciences

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4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile

Properties

Safety Information

Description

Related product price

Suppliers and manufacturers