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ChemicalBook >> CAS DataBase List >> 5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-

5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-

5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]- price.
  • $27 - $2200
  • Product name: 5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-
  • CAS: 919486-40-1
  • MF: C20H20ClN5O2
  • MW: 397.86
  • EINECS:
  • MDL Number:MFCD24038757
  • Synonyms:5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-;AS 1517499;4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide;AS-1517499;AS 1517499;AS-1517499; AS1517499; AS 1517499;919486-40-1;CS-2440;STAT,AS-1517499,inhibit,AS 1517499,AS1517499,Inhibitor;AS1517499, 10 mM in DMSO
65 prices
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  • A2B
  • aablocks
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Package
  • 2mg
  • 10mM*1mLinDMSO
  • 1mg
  • 5mg
  • 5.00mg
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  • 10.00mg
  • 2x10mg
  • 25.00mg
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  • 1g
  • ManufacturerA2B
  • Product numberAX46894
  • Product descriptionAS-1517499 97%
  • Packaging2mg
  • Price$37
  • Updated2026-05-25
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  • ManufacturerA2B
  • Product numberAX46894
  • Product descriptionAS-1517499 97%
  • Packaging5mg
  • Price$47
  • Updated2026-05-25
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  • ManufacturerA2B
  • Product numberAX46894
  • Product descriptionAS-1517499 97%
  • Packaging10mg
  • Price$71
  • Updated2026-05-25
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  • ManufacturerA2B
  • Product numberAX46894
  • Product descriptionAS-1517499 97%
  • Packaging25mg
  • Price$110
  • Updated2026-05-25
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  • ManufacturerA2B
  • Product numberAX46894
  • Product descriptionAS-1517499 97%
  • Packaging50mg
  • Price$133
  • Updated2026-05-25
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  • ManufacturerA2B
  • Product numberAX46894
  • Product descriptionAS-1517499 97%
  • Packaging100mg
  • Price$193
  • Updated2026-05-25
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  • ManufacturerA2B
  • Product numberAX46894
  • Product descriptionAS-1517499 97%
  • Packaging250mg
  • Price$385
  • Updated2026-05-25
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  • ManufacturerA2B
  • Product numberAX46894
  • Product descriptionAS-1517499 97%
  • Packaging1mg
  • Price$27
  • Updated2026-05-25
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  • Manufactureraablocks
  • Product numberAA01EAYA
  • Product descriptionAS-1517499 97%
  • Packaging1mg
  • Price$31
  • Updated2026-05-30
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  • Manufactureraablocks
  • Product numberAA01EAYA
  • Product descriptionAS-1517499 97%
  • Packaging250mg
  • Price$429
  • Updated2026-05-30
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  • Manufactureraablocks
  • Product numberAA01EAYA
  • Product descriptionAS-1517499 97%
  • Packaging100mg
  • Price$215
  • Updated2026-05-30
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  • Manufactureraablocks
  • Product numberAA01EAYA
  • Product descriptionAS-1517499 97%
  • Packaging50mg
  • Price$148
  • Updated2026-05-30
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  • Manufactureraablocks
  • Product numberAA01EAYA
  • Product descriptionAS-1517499 97%
  • Packaging25mg
  • Price$122
  • Updated2026-05-30
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  • Manufactureraablocks
  • Product numberAA01EAYA
  • Product descriptionAS-1517499 97%
  • Packaging10mg
  • Price$79
  • Updated2026-05-30
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  • Manufactureraablocks
  • Product numberAA01EAYA
  • Product descriptionAS-1517499 97%
  • Packaging5mg
  • Price$53
  • Updated2026-05-30
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  • ManufacturerACHEMBLOCK
  • Product numberZ238634
  • Product descriptionAS1517499 98%
  • Packaging100MG
  • Price$315
  • Updated2026-05-27
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
A2B AX46894 AS-1517499 97% 2mg $37 2026-05-25 Buy
A2B AX46894 AS-1517499 97% 5mg $47 2026-05-25 Buy
A2B AX46894 AS-1517499 97% 10mg $71 2026-05-25 Buy
A2B AX46894 AS-1517499 97% 25mg $110 2026-05-25 Buy
A2B AX46894 AS-1517499 97% 50mg $133 2026-05-25 Buy
A2B AX46894 AS-1517499 97% 100mg $193 2026-05-25 Buy
A2B AX46894 AS-1517499 97% 250mg $385 2026-05-25 Buy
A2B AX46894 AS-1517499 97% 1mg $27 2026-05-25 Buy
aablocks AA01EAYA AS-1517499 97% 1mg $31 2026-05-30 Buy
aablocks AA01EAYA AS-1517499 97% 250mg $429 2026-05-30 Buy
aablocks AA01EAYA AS-1517499 97% 100mg $215 2026-05-30 Buy
aablocks AA01EAYA AS-1517499 97% 50mg $148 2026-05-30 Buy
aablocks AA01EAYA AS-1517499 97% 25mg $122 2026-05-30 Buy
aablocks AA01EAYA AS-1517499 97% 10mg $79 2026-05-30 Buy
aablocks AA01EAYA AS-1517499 97% 5mg $53 2026-05-30 Buy
ACHEMBLOCK Z238634 AS1517499 98% 100MG $315 2026-05-27 Buy

Properties

storage temp. :2-8°C
solubility :DMF: 25mg/mL; DMF:PBS (pH 7.2) (1:6): 0.14mg/mL; DMSO: 15mg/mL; Ethanol: 5mg/mL
form :powder
color :white to beige
InChI :InChI=1S/C20H20ClN5O2/c21-16-10-13(6-7-17(16)27)8-9-23-20-25-12-15(18(22)28)19(26-20)24-11-14-4-2-1-3-5-14/h1-7,10,12,27H,8-9,11H2,(H2,22,28)(H2,23,24,25,26)
InChIKey :OZRMEKAUZBKTTC-UHFFFAOYSA-N
SMILES :C1(NCCC2=CC=C(O)C(Cl)=C2)=NC=C(C(N)=O)C(NCC2=CC=CC=C2)=N1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

AS1517499 is a STAT6 inhibitor (IC50 = 21 nM in a reporter assay). It inhibits IL-4-induced Th2 differentiation (IC50 = 2.3 nM), but not IL-12-induced Th1 differentiation, of mouse spleen T cells. AS1517499 (10 mg/kg) inhibits bronchial smooth muscle hyperresponsiveness and IL-13 production in ovalbumin-sensitized mice when administered one hour prior to antigen exposure. It inhibits STAT6 phosphorylation and thyroid epithelial cell (TEC) hyperplasia and decreases serum levels of 3,3'',5-triiodo-L-thyronine (T3; ) and thyroxine (T4) in a mouse model of Graves'' disease when administered at a dose of 10 mg/kg per day. AS1517499 (20 mg/kg twice weekly) also inhibits tumor growth and liver metastasis in a murine orthotopic 4T1 mammary carcinoma model.

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