AZ 628
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- $25 - $2841
- Product name: AZ 628
- CAS: 878739-06-1
- MF: C27H25N5O2
- MW: 451.52
- EINECS:
- MDL Number:MFCD17392577
- Synonyms:3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide;AZ-628;AZ628/AZ-628;AZD628;3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide;AZ628, >=99%;3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)ben;Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]-
90 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solution)
- 2mg
- 2.5mg
- 1mg
- 10mM(1mLinDMSO)
- 10mM*1mLinDMSO(Solid+Solvent)
- 50
- 10mg
- 5mg
- 10
- 50mg
- 100mg
- 250.00mg
- 1g
- 1.00g
- 25mg
- 250mg
- 10mM(in1mLDMSO)
- 10mM(in 1mL DMSO)
- 1000mg
- Manufactureraablocks
- Product numberAA00GTYC
- Product description3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98%
- Packaging25mg
- Price$140
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTYC
- Product description3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98%
- Packaging10mg
- Price$70
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTYC
- Product description3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98%
- Packaging50mg
- Price$223
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTYC
- Product description3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98
- Packaging100mg
- Price$319
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTYC
- Product description3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98%
- Packaging5mg
- Price$45
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTYC
- Product description3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98%
- Packaging1mg
- Price$26
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228749
- Product descriptionAZ 628 97.00%
- Packaging25MG
- Price$215
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228749
- Product descriptionAZ 628 97.00%
- Packaging100MG
- Price$445
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberY0332
- Product descriptionAZ628
- Packaging1mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0388678
- Product description3-(2-CYANOPROPAN-2-YL)-N-(4-METHYL-3-((3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO)PHENYL)BENZAMIDE 95.00%
- Packaging5MG
- Price$502.88
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ628
- Packaging50mg
- Price$360
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ 628
- Packaging50mg
- Price$360
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ628
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ 628
- Packaging5mg
- Price$70
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ628
- Packaging10mM(in 1mL DMSO)
- Price$77
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ 628
- Packaging10mM(in1mLDMSO)
- Price$77
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00GTYC | 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98% | 25mg | $140 | 2026-05-28 | Buy |
| aablocks | AA00GTYC | 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98% | 10mg | $70 | 2026-05-28 | Buy |
| aablocks | AA00GTYC | 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98% | 50mg | $223 | 2026-05-28 | Buy |
| aablocks | AA00GTYC | 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98 | 100mg | $319 | 2026-05-28 | Buy |
| aablocks | AA00GTYC | 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98% | 5mg | $45 | 2026-05-28 | Buy |
| aablocks | AA00GTYC | 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98% | 1mg | $26 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y228749 | AZ 628 97.00% | 25MG | $215 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228749 | AZ 628 97.00% | 100MG | $445 | 2026-05-27 | Buy |
| AK Scientific | Y0332 | AZ628 | 1mg | $25 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0388678 | 3-(2-CYANOPROPAN-2-YL)-N-(4-METHYL-3-((3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO)PHENYL)BENZAMIDE 95.00% | 5MG | $502.88 | 2021-12-16 | Buy |
| ApexBio Technology | A8371 | AZ628 | 50mg | $360 | 2021-12-16 | Buy |
| ApexBio Technology | A8371 | AZ 628 | 50mg | $360 | 2026-05-06 | Buy |
| ApexBio Technology | A8371 | AZ628 | 5mg | $70 | 2021-12-16 | Buy |
| ApexBio Technology | A8371 | AZ 628 | 5mg | $70 | 2026-05-06 | Buy |
| ApexBio Technology | A8371 | AZ628 | 10mM(in 1mL DMSO) | $77 | 2021-12-16 | Buy |
| ApexBio Technology | A8371 | AZ 628 | 10mM(in1mLDMSO) | $77 | 2026-05-06 | Buy |
Properties
Density :1.21±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :12.92±0.70(Predicted)
color :white to beige
InChI :1S/C27H25N5O2/c1-17-8-9-21(31-25(33)18-6-5-7-19(12-18)27(2,3)15-28)14-24(17)30-20-10-11-23-22(13-20)26(34)32(4)16-29-23/h5-14,16,30H,1-4H3,(H,31,33)
InChIKey :ZGBGPEDJXCYQPH-UHFFFAOYSA-N
SMILES :[n]1([c](c2c(nc1)ccc(c2)Nc3c(ccc(c3)NC(=O)c4cc(ccc4)C(C)(C)C#N)C)=O)C
storage temp. :-20°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :12.92±0.70(Predicted)
color :white to beige
InChI :1S/C27H25N5O2/c1-17-8-9-21(31-25(33)18-6-5-7-19(12-18)27(2,3)15-28)14-24(17)30-20-10-11-23-22(13-20)26(34)32(4)16-29-23/h5-14,16,30H,1-4H3,(H,31,33)
InChIKey :ZGBGPEDJXCYQPH-UHFFFAOYSA-N
SMILES :[n]1([c](c2c(nc1)ccc(c2)Nc3c(ccc(c3)NC(=O)c4cc(ccc4)C(C)(C)C#N)C)=O)C
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||||||||||||||||
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Description
The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. Mutations in the kinase B-Raf are involved in a wide range of cancers. In particular, the mutation B-RafV600E occurs in melanomas and other types of cancer but is poorly targeted by many inhibitors of wild type B-Raf. AZ 628 is a quinazilinone that inhibits several Raf kinases, including B-Raf, B-RafV600E, and c-Raf-1 (IC50s = 105, 34, and 29 nM in in vitro kinase assays). It also prevents activation of several tyrosine kinases, including VEGFR2, DDR2, Lyn, Flt1, and FMS. In colon and melanoma cell lines carrying B-RafV600E mutations, AZ 628 is reported to inhibit anchorage-dependent and -independent growth, induce cell cycle arrest, and cause apoptosis.Related product price
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