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ChemicalBook >> CAS DataBase List >> BRL 50481

BRL 50481

BRL 50481 price.
  • $9 - $2691.1
  • Product name: BRL 50481
  • CAS: 433695-36-4
  • MF: C9H12N2O4S
  • MW: 244.27
  • EINECS:1592732-453-0
  • MDL Number:MFCD03039912
  • Synonyms:5-NITRO-2,N,N-TRIMETHYLBENZENESULFONAMIDE;BRL 50481;N,N,2-TRIMETHYL-5-NITRO-BENZENESULFONAMIDE;3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene,5-Nitro-2-N,N-trimethylbenzenesulfonamide;Benzenesulfonamide, N,N,2-trimethyl-5-nitro-;-50481;BRL-50481, Selective PDE7 inhibitor;BRL-50481 (BRL50481
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  • aablocks
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  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
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  • Manufactureraablocks
  • Product numberAA00D9NY
  • Product descriptionN,N,2-Trimethyl-5-Nitrobenzenesulfonamide 99%
  • Packaging1mg
  • Price$9
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00D9NY
  • Product descriptionN,N,2-Trimethyl-5-Nitrobenzenesulfonamide 99%
  • Packaging5mg
  • Price$16
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00D9NY
  • Product descriptionN,N,2-Trimethyl-5-Nitrobenzenesulfonamide 99%
  • Packaging10mg
  • Price$22
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00D9NY
  • Product descriptionN,N,2-Trimethyl-5-Nitrobenzenesulfonamide 99%
  • Packaging25mg
  • Price$34
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00D9NY
  • Product descriptionN,N,2-Trimethyl-5-Nitrobenzenesulfonamide 99%
  • Packaging50mg
  • Price$55
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00D9NY
  • Product descriptionN,N,2-Trimethyl-5-Nitrobenzenesulfonamide 98%
  • Packaging250mg
  • Price$63
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00D9NY
  • Product descriptionN,N,2-Trimethyl-5-Nitrobenzenesulfonamide 98%
  • Packaging1g
  • Price$140
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00D9NY
  • Product descriptionN,N,2-Trimethyl-5-Nitrobenzenesulfonamide 98%
  • Packaging5g
  • Price$407
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00D9NY
  • Product descriptionN,N,2-Trimethyl-5-Nitrobenzenesulfonamide 98%
  • Packaging10g
  • Price$674
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00D9NY
  • Product descriptionN,N,2-Trimethyl-5-Nitrobenzenesulfonamide 98%
  • Packaging25g
  • Price$1342
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberS86711
  • Product descriptionBRL 50481 98%
  • Packaging5G
  • Price$440
  • Updated2026-05-25
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  • ManufacturerACHEMBLOCK
  • Product numberS86711
  • Product descriptionBRL 50481 98%
  • Packaging5G
  • Price$440
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberS86711
  • Product descriptionBRL 50481 98%
  • Packaging1G
  • Price$110
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberS86711
  • Product descriptionBRL 50481 98%
  • Packaging1G
  • Price$110
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number4516CJ
  • Product descriptionN,N,2-Trimethyl-5-nitrobenzenesulfonamide
  • Packaging100mg
  • Price$212
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024926
  • Product descriptionBRL 50481 95.00%
  • Packaging100MG
  • Price$1593.9
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00D9NY N,N,2-Trimethyl-5-Nitrobenzenesulfonamide 99% 1mg $9 2026-05-28 Buy
aablocks AA00D9NY N,N,2-Trimethyl-5-Nitrobenzenesulfonamide 99% 5mg $16 2026-05-28 Buy
aablocks AA00D9NY N,N,2-Trimethyl-5-Nitrobenzenesulfonamide 99% 10mg $22 2026-05-28 Buy
aablocks AA00D9NY N,N,2-Trimethyl-5-Nitrobenzenesulfonamide 99% 25mg $34 2026-05-28 Buy
aablocks AA00D9NY N,N,2-Trimethyl-5-Nitrobenzenesulfonamide 99% 50mg $55 2026-05-28 Buy
aablocks AA00D9NY N,N,2-Trimethyl-5-Nitrobenzenesulfonamide 98% 250mg $63 2026-05-28 Buy
aablocks AA00D9NY N,N,2-Trimethyl-5-Nitrobenzenesulfonamide 98% 1g $140 2026-05-28 Buy
aablocks AA00D9NY N,N,2-Trimethyl-5-Nitrobenzenesulfonamide 98% 5g $407 2026-05-28 Buy
aablocks AA00D9NY N,N,2-Trimethyl-5-Nitrobenzenesulfonamide 98% 10g $674 2026-05-28 Buy
aablocks AA00D9NY N,N,2-Trimethyl-5-Nitrobenzenesulfonamide 98% 25g $1342 2026-05-28 Buy
ACHEMBLOCK S86711 BRL 50481 98% 5G $440 2026-05-25 Buy
ACHEMBLOCK S86711 BRL 50481 98% 5G $440 2026-05-27 Buy
ACHEMBLOCK S86711 BRL 50481 98% 1G $110 2026-05-25 Buy
ACHEMBLOCK S86711 BRL 50481 98% 1G $110 2026-05-27 Buy
AK Scientific 4516CJ N,N,2-Trimethyl-5-nitrobenzenesulfonamide 100mg $212 2021-12-16 Buy
American Custom Chemicals Corporation API0024926 BRL 50481 95.00% 100MG $1593.9 2021-12-16 Buy

Properties

Melting point :65-67°C
Boiling point :391.1±52.0 °C(Predicted)
Density :1.334±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 12 mg/mL
form :solid
pka :-5+-.0.70(Predicted)
color :white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI :1S/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3
InChIKey :IFIUFCJFLGCQPH-UHFFFAOYSA-N
SMILES :CN(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

BRL 50481 is a potent, selective inhibitor of phosphodiesterase (PDE) 7, inhibiting human recombinant PDE7A1 with a Ki value of 180 nM. It is much less effective against PDE3 and PDE4 and is without effect against PDE1B, PDE1C, PDE2, and PDE5. Through its effects on PDE7A1, BRL 50481 enhances the inhibitory effects of the PDE4 blocker rolipram on monocytes, lung macrophages, and CD8+ T-lymphocytes. BRL 50481, at 30 μM, promotes apoptosis in chronic lymphocytic leukemia cells overexpressing PDE7B, suggesting that this compound also acts against PDE7B. BRL 50481 can be used to evaluate the role of PDE7 isoforms in intracellular signaling.

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