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Description

DPY-30 is a component of the MLL1 methylation complex, which interacts directly with Ash2L.1 In C. elegans, DPY-30 is required for dosage compensation in XX individuals, and its deletion or mutation is lethal. For XO individuals, DPY-30 is required for proper growth and development.2,3 DPY-30 is a homodimer in solution, and two monomers interact with one Ash2L monomer.4 Addition of DPY-30 to the MLL1, WDR5, RbBP5, and Ash2L complex results in a 2-fold increase in methylation rate, from 300x the MLL1 basal rate to 600x the MLL1 basal rate.5WARNING This product is not for human or veterinary use.