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ChemicalBook >> CAS DataBase List >> CO-1686 intermediate 1

CO-1686 intermediate 1

$126 - $2260
Product name: CO-1686 intermediate 1
CAS: 1374507-25-1
MF: C14H10ClF3N4O
MW: 342.7
EINECS:
MDL Number:MFCD28965167
Synonyms:CO-1686 intermediate 1;N-(3-((2-chloro-5-(trifluoromethyl)pyri midin-4-yl)amino)phenyl)acrylamide;N-[3-[[2-Chloro-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide;N-(3-{[2-chloro-5-(trifluoromethyl)pyrimidin-4-yl]amino}phenyl)prop-2-enamide;ROCI-005;2-Propenamide, N-[3-[[2-chloro-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-

Price18 Properties Safety Information Description

18 prices

Selected condition：

Brand

aablocks
ACHEMBLOCK
Alichem
American Custom Chemicals Corporation
Chemenu
Crysdot
TRC

Package

5MG
100mg
250mg
1g
5g
10g

Manufactureraablocks
Product numberAA00137X
Product descriptionN-[3-[[2-Chloro-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
Packaging5g
Price$1003
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00137X
Product descriptionN-[3-[[2-Chloro-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
Packaging1g
Price$339
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00137X
Product descriptionN-[3-[[2-Chloro-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
Packaging250mg
Price$148
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00137X
Product descriptionN-[3-[[2-Chloro-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
Packaging100mg
Price$126
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00137X
Product descriptionN-[3-[[2-Chloro-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
Packaging10g
Price$1789
Updated2026-05-28
Buy

ManufacturerACHEMBLOCK
Product numberL14986
Product descriptionN-(3-{[2-chloro-5-(trifluoromethyl)pyrimidin-4-yl]amino}phenyl)prop-2-enamide 97%
Packaging5G
Price$1410
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberL14986
Product descriptionN-(3-{[2-chloro-5-(trifluoromethyl)pyrimidin-4-yl]amino}phenyl)prop-2-enamide 97%
Packaging5G
Price$1410
Updated2026-05-27
Buy

ManufacturerAlichem
Product number1374507251
Product descriptionN-(3-((2-Chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide
Packaging10g
Price$1060
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberHCH0620699
Product descriptionN-(3-(2-CHLORO-5-(TRIFLUOROMETHYL)PYRIMIDIN-4-YLAMINO)PHENYL)ACRYLAMIDE 95.00%
Packaging5MG
Price$499.09
Updated2021-12-16
Buy

ManufacturerChemenu
Product numberCM167724
Product descriptionN-(3-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 95+%
Packaging10g
Price$935
Updated2021-12-16
Buy

ManufacturerChemenu
Product numberCM167724
Product descriptionN-(3-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 95+%
Packaging5g
Price$561
Updated2021-12-16
Buy

ManufacturerChemenu
Product numberCM167724
Product descriptionN-(3-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 95%+
Packaging10g
Price$2260
Updated2026-05-26
Buy

ManufacturerChemenu
Product numberCM167724
Product descriptionN-(3-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 95%+
Packaging10g
Price$2260
Updated2026-05-20
Buy

ManufacturerCrysdot
Product numberCD11269935
Product descriptionN-(3-((2-Chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 97%
Packaging5g
Price$600
Updated2021-12-16
Buy

ManufacturerCrysdot
Product numberCD11269935
Product descriptionN-(3-((2-Chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 97%
Packaging10g
Price$1000
Updated2021-12-16
Buy

ManufacturerCrysdot
Product numberCD11269935
Product descriptionN-(3-((2-Chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 97%
Packaging10g
Price$1000
Updated2026-05-26
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA00137X	N-[3-[[2-Chloro-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%	5g	$1003	2026-05-28	Buy
aablocks	AA00137X	N-[3-[[2-Chloro-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%	1g	$339	2026-05-28	Buy
aablocks	AA00137X	N-[3-[[2-Chloro-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%	250mg	$148	2026-05-28	Buy
aablocks	AA00137X	N-[3-[[2-Chloro-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%	100mg	$126	2026-05-28	Buy
aablocks	AA00137X	N-[3-[[2-Chloro-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%	10g	$1789	2026-05-28	Buy
ACHEMBLOCK	L14986	N-(3-{[2-chloro-5-(trifluoromethyl)pyrimidin-4-yl]amino}phenyl)prop-2-enamide 97%	5G	$1410	2026-05-25	Buy
ACHEMBLOCK	L14986	N-(3-{[2-chloro-5-(trifluoromethyl)pyrimidin-4-yl]amino}phenyl)prop-2-enamide 97%	5G	$1410	2026-05-27	Buy
Alichem	1374507251	N-(3-((2-Chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide	10g	$1060	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0620699	N-(3-(2-CHLORO-5-(TRIFLUOROMETHYL)PYRIMIDIN-4-YLAMINO)PHENYL)ACRYLAMIDE 95.00%	5MG	$499.09	2021-12-16	Buy
Chemenu	CM167724	N-(3-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 95+%	10g	$935	2021-12-16	Buy
Chemenu	CM167724	N-(3-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 95+%	5g	$561	2021-12-16	Buy
Chemenu	CM167724	N-(3-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 95%+	10g	$2260	2026-05-26	Buy
Chemenu	CM167724	N-(3-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 95%+	10g	$2260	2026-05-20	Buy
Crysdot	CD11269935	N-(3-((2-Chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 97%	5g	$600	2021-12-16	Buy
Crysdot	CD11269935	N-(3-((2-Chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 97%	10g	$1000	2021-12-16	Buy
Crysdot	CD11269935	N-(3-((2-Chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 97%	10g	$1000	2026-05-26	Buy

Next Last

Properties

Boiling point :519.7±50.0 °C(Predicted)
Density :1.476±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
pka :13.21±0.70(Predicted)
InChI :InChI=1S/C14H10ClF3N4O/c1-2-11(23)20-8-4-3-5-9(6-8)21-12-10(14(16,17)18)7-19-13(15)22-12/h2-7H,1H2,(H,20,23)(H,19,21,22)
InChIKey :AXMHVOLJINONIM-UHFFFAOYSA-N
SMILES :C(NC1=CC=CC(NC2C(C(F)(F)F)=CN=C(Cl)N=2)=C1)(=O)C=C

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P321	Specific treatment (see … on this label).
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P337+P313	IF eye irritation persists: Get medical advice/attention.
P362	Take off contaminated clothing and wash before reuse.
P403+P233	Store in a well-ventilated place. Keep container tightly closed.
P405	Store locked up.
P501	Dispose of contents/container to..…

Description

N-(3-{[2-Chloro-5-(trifluoromethyl)pyrimidin-4-yl]amino}phenyl)prop-2-enamide can be used as potent BTK and JAK3 dual inhibitors.

Suppliers and manufacturers

Capot Chemical Co.,Ltd.

Biochempartner

Career Henan Chemica Co

AFINE CHEMICALS LIMITED

HANGZHOU LEAP CHEM CO., LTD.

Coresyn Pharmatech Co., Ltd.

Aceschem Inc.

Aladdin Scientific

Suzhou ARTK Medchem Co., Ltd.

Chongqing Chemdad Co., Ltd

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CO-1686 intermediate 1

Properties

Safety Information

Description

Suppliers and manufacturers