Cladribine
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- $11 - $1504.5
- Product name: Cladribine
- CAS: 4291-63-8
- MF: C10H12ClN5O3
- MW: 285.69
- EINECS:636-978-6
- MDL Number:MFCD00153939
- Synonyms:2-chlorodeoxyadenosine ;Biodribin;Cladarabine;Jk 6251;NSC 105014;(2R,3S,5R)-5-(6-aMino-2-chloro-9H-purin-9-yl)-2-(hydroxyMethyl)oxolan-3-ol;Cladribine API;2-Chloro-2'-deoxyadenosine 2-Chloro-9-(2-deoxy-beta-D-arabinofuranosyl)adenine CdA
113 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AHH
- AK Scientific
- Ambeed
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- BroadPharm
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 1mg
- y0000639
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- 50
- 10μg
- y0000609
- 10
- 10mM(in1mLDMSO)
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250.00mg
- 250mg
- 500mg
- 1g
- 1.00g
- 5G
- 5.00g
- 10 mg
- 48Tests
- 100 mg
- Manufactureraablocks
- Product numberAA003OXR
- Product description2-CHLORO-2'-DEOXYADENOSINE 98%
- Packaging1mg
- Price$11
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003OXR
- Product description2-CHLORO-2'-DEOXYADENOSINE 98%
- Packaging10mg
- Price$27
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003OXR
- Product description2-CHLORO-2'-DEOXYADENOSINE 98%
- Packaging100mg
- Price$31
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003OXR
- Product description2-CHLORO-2'-DEOXYADENOSINE 98%
- Packaging250mg
- Price$46
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003OXR
- Product description2-CHLORO-2'-DEOXYADENOSINE 98%
- Packaging1g
- Price$107
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberR16044
- Product descriptionCladribine 98%
- Packaging1G
- Price$135
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberR16044
- Product descriptionCladribine 98%
- Packaging5G
- Price$685
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberCDX-C0805-M050
- Product description2-Chloro-2'-deoxyadenosine ≥98%(HPLC)
- Packaging50mg
- Price$131
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberCDX-C0805-M010
- Product description2-Chloro-2'-deoxyadenosine ≥98%(HPLC)
- Packaging10mg
- Price$31
- Updated2026-05-06
- Buy
- ManufacturerAHH
- Product numberMT-49426
- Product descriptionCladribine 98%
- Packaging1g
- Price$430
- Updated2021-12-16
- Buy
- ManufacturerAHH
- Product numberMT-49426
- Product descriptionCladribine 97%
- Packaging1g
- Price$430
- Updated2026-05-25
- Buy
- ManufacturerAHH
- Product numberMT-49426
- Product descriptionCladribine 97%
- Packaging1g
- Price$430
- Updated2026-05-26
- Buy
- ManufacturerAK Scientific
- Product numberE997
- Product descriptionCladribine
- Packaging50mg
- Price$469
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA410468
- Product description(2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+%
- Packaging5g
- Price$672
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA410468
- Product description(2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+%
- Packaging10mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA410468
- Product description(2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+%
- Packaging100mg
- Price$43
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA003OXR | 2-CHLORO-2'-DEOXYADENOSINE 98% | 1mg | $11 | 2026-05-28 | Buy |
| aablocks | AA003OXR | 2-CHLORO-2'-DEOXYADENOSINE 98% | 10mg | $27 | 2026-05-28 | Buy |
| aablocks | AA003OXR | 2-CHLORO-2'-DEOXYADENOSINE 98% | 100mg | $31 | 2026-05-28 | Buy |
| aablocks | AA003OXR | 2-CHLORO-2'-DEOXYADENOSINE 98% | 250mg | $46 | 2026-05-28 | Buy |
| aablocks | AA003OXR | 2-CHLORO-2'-DEOXYADENOSINE 98% | 1g | $107 | 2026-05-28 | Buy |
| ACHEMBLOCK | R16044 | Cladribine 98% | 1G | $135 | 2026-05-27 | Buy |
| ACHEMBLOCK | R16044 | Cladribine 98% | 5G | $685 | 2026-05-27 | Buy |
| Adipogen Life Sciences | CDX-C0805-M050 | 2-Chloro-2'-deoxyadenosine ≥98%(HPLC) | 50mg | $131 | 2026-05-06 | Buy |
| Adipogen Life Sciences | CDX-C0805-M010 | 2-Chloro-2'-deoxyadenosine ≥98%(HPLC) | 10mg | $31 | 2026-05-06 | Buy |
| AHH | MT-49426 | Cladribine 98% | 1g | $430 | 2021-12-16 | Buy |
| AHH | MT-49426 | Cladribine 97% | 1g | $430 | 2026-05-25 | Buy |
| AHH | MT-49426 | Cladribine 97% | 1g | $430 | 2026-05-26 | Buy |
| AK Scientific | E997 | Cladribine | 50mg | $469 | 2021-12-16 | Buy |
| Ambeed | A410468 | (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+% | 5g | $672 | 2021-12-16 | Buy |
| Ambeed | A410468 | (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+% | 10mg | $25 | 2021-12-16 | Buy |
| Ambeed | A410468 | (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+% | 100mg | $43 | 2021-12-16 | Buy |
Properties
Melting point :181-185 °C(lit.)
alpha :D25 -18.8° (c = 1 in DMF)
Boiling point :547.6±60.0 °C(Predicted)
Density :2.03±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Slightly soluble in water, soluble in dimethyl sulfoxide, slightly soluble in methanol, practically insoluble in acetonitrile. It shows polymorphism (5.9).
pka :13.75±0.60(Predicted)
form :White solid
color :White to Pale Yellow
λmax :265nm(EtOH aq.)(lit.)
Merck :14,2337
Stability :Store in Freezer
Major Application :pharmaceutical (small molecule)
InChI :InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
InChIKey :PTOAARAWEBMLNO-HSUXUTPPSA-N
SMILES :OC[C@H]1O[C@@H](N2C3C(=C(N=C(Cl)N=3)N)N=C2)C[C@@H]1O
CAS DataBase Reference :4291-63-8(CAS DataBase Reference)
alpha :D25 -18.8° (c = 1 in DMF)
Boiling point :547.6±60.0 °C(Predicted)
Density :2.03±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Slightly soluble in water, soluble in dimethyl sulfoxide, slightly soluble in methanol, practically insoluble in acetonitrile. It shows polymorphism (5.9).
pka :13.75±0.60(Predicted)
form :White solid
color :White to Pale Yellow
λmax :265nm(EtOH aq.)(lit.)
Merck :14,2337
Stability :Store in Freezer
Major Application :pharmaceutical (small molecule)
InChI :InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
InChIKey :PTOAARAWEBMLNO-HSUXUTPPSA-N
SMILES :OC[C@H]1O[C@@H](N2C3C(=C(N=C(Cl)N=3)N)N=C2)C[C@@H]1O
CAS DataBase Reference :4291-63-8(CAS DataBase Reference)
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | ||||||||||||||||||||||||||||
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Description
Cladribine (2-chloro-2′-deoxyadenosine) is an adenosine deaminase-resistant analogue of deoxyadenosine. The drug has a broad range of in vitro activity against both lymphoid and myeloid neoplasms [mean IC50values (drug concentration required to inhibit cell growth by 50% of control): 20 to 87 nmol/L]. But it possesses little activity against multiple myeloma specimens and many solid tumor cell lines. Monocytes are highly sensitive to cladribine in vitro. Cladribine demonstrates activity against both dividing and nondividing cells and this activity distinguishes it from many other agents. It has activity in murine models of leukaemia. Cladribine is used to treat chronic progressive multiple sclerosis, hairy cell leukemia, systemic mastocytosis, and histiocytosis (including Erdheim–Chester disease and Langerhans cell histiocytosis).After a 2-hour intravenous infusion of cladribine 0.14 mg/kg/day, the mean maximum plasma drug concentration was 198 nmol/L. Intracellular concentrations of phosphorylated cladribine derivatives exceed plasma concentrations 128- to 375-fold. Cladribine penetrates into the CSF. The terminal elimination half-life (6.7 hours) is long, which suggests that the drug may be administered intermittently without loss of efficacy. The volume of distribution of cladribine is 9.2 L/kg.
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Suppliers and manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
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Wuhan JiyunZen Tech Co., Ltd.
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Zhejiang ZETian Fine Chemicals Co. LTD
Hainan Xiyuan Chemical Technology Co., Ltd.
Cladribine
CAS:4291-63-8
