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ChemicalBook >> CAS DataBase List >> Efaproxiral

Efaproxiral

Efaproxiral price.
  • $49 - $1675
  • Product name: Efaproxiral
  • CAS: 131179-95-8
  • MF: C20H22NO4.Na
  • MW: 341.4
  • EINECS:1806241-263-5
  • MDL Number:MFCD00899086
  • Synonyms:2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid;Efaproxiral;Efaproxiral free acid;faproxiral;EFAPROXIRALUM;2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid;EFAPROXIRAL;EFAPROXIRAL FREE ACID;FAPROXIRAL;Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-
34 prices
Selected condition:
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • American Custom Chemicals Corporation
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • TRC
Package
  • 0.025g
  • 50mg
  • 0.05g
  • 0.1g
  • 100mg
  • 0.25g
  • 250mg
  • 500mg
  • 0.5g
  • 1g
  • 2.5G
  • Manufactureraablocks
  • Product numberAA000VKE
  • Product description2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid 95%
  • Packaging100mg
  • Price$56
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000VKE
  • Product description2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid 95%
  • Packaging250mg
  • Price$135
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000VKE
  • Product description2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid 95%
  • Packaging1g
  • Price$162
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberAD266221
  • Product descriptionEfaproxiral 98%
  • Packaging250MG
  • Price$520
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberAD266221
  • Product descriptionEfaproxiral 98%
  • Packaging1G
  • Price$1040
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number5787AA
  • Product description2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoicacid
  • Packaging1g
  • Price$694
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0005193
  • Product descriptionEFAPROXIRA 95.00%
  • Packaging1G
  • Price$910
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0005193
  • Product descriptionEFAPROXIRA 95.00%
  • Packaging2.5G
  • Price$1675
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0005193
  • Product descriptionEFAPROXIRA 95.00%
  • Packaging250MG
  • Price$527.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth
  • Product numberFE22644
  • Product descriptionEfaproxiral
  • Packaging0.1g
  • Price$356.95
  • Updated2026-06-04
  • Buy
  • ManufacturerBiosynth
  • Product numberFE22644
  • Product descriptionEfaproxiral
  • Packaging0.05g
  • Price$228.45
  • Updated2026-06-04
  • Buy
  • ManufacturerBiosynth
  • Product numberFE22644
  • Product descriptionEfaproxiral
  • Packaging0.5g
  • Price$999.46
  • Updated2026-06-04
  • Buy
  • ManufacturerBiosynth
  • Product numberFE22644
  • Product descriptionEfaproxiral
  • Packaging0.25g
  • Price$571.12
  • Updated2026-06-04
  • Buy
  • ManufacturerBiosynth
  • Product numberFE22644
  • Product descriptionEfaproxiral
  • Packaging0.025g
  • Price$150
  • Updated2026-06-04
  • Buy
  • ManufacturerCayman Chemical
  • Product number28294
  • Product descriptionEfaproxiral
  • Packaging250mg
  • Price$161
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28294
  • Product descriptionEfaproxiral ≥98%
  • Packaging250mg
  • Price$178
  • Updated2026-04-30
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA000VKE 2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid 95% 100mg $56 2026-05-25 Buy
aablocks AA000VKE 2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid 95% 250mg $135 2026-05-25 Buy
aablocks AA000VKE 2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid 95% 1g $162 2026-05-25 Buy
ACHEMBLOCK AD266221 Efaproxiral 98% 250MG $520 2026-05-27 Buy
ACHEMBLOCK AD266221 Efaproxiral 98% 1G $1040 2026-05-27 Buy
AK Scientific 5787AA 2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoicacid 1g $694 2021-12-16 Buy
American Custom Chemicals Corporation API0005193 EFAPROXIRA 95.00% 1G $910 2021-12-16 Buy
American Custom Chemicals Corporation API0005193 EFAPROXIRA 95.00% 2.5G $1675 2021-12-16 Buy
American Custom Chemicals Corporation API0005193 EFAPROXIRA 95.00% 250MG $527.5 2021-12-16 Buy
Biosynth FE22644 Efaproxiral 0.1g $356.95 2026-06-04 Buy
Biosynth FE22644 Efaproxiral 0.05g $228.45 2026-06-04 Buy
Biosynth FE22644 Efaproxiral 0.5g $999.46 2026-06-04 Buy
Biosynth FE22644 Efaproxiral 0.25g $571.12 2026-06-04 Buy
Biosynth FE22644 Efaproxiral 0.025g $150 2026-06-04 Buy
Cayman Chemical 28294 Efaproxiral 250mg $161 2024-03-01 Buy
Cayman Chemical 28294 Efaproxiral ≥98% 250mg $178 2026-04-30 Buy

Properties

Melting point :48-50°C
Boiling point :554.5±50.0 °C(Predicted)
Density :1.202±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :3.26±0.10(Predicted)
color :Off-White to Tan

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

Efaproxiral is an allosteric hemoglobin (Hb) modifier that reduces the affinity of Hb for oxygen, increasing the diffusion of oxygen from blood to tissue. In isolated human whole blood, efaproxiral (1.75 mM) increases the partial pressure of oxygen at which Hb is 50% saturated (p50) from 26.75 to 38.63 mm Hg and decreases the percent oxyhemoglobin (Hb-O2) saturation from 48 to 33.8% at a partial oxygen pressure (pO2) of 26 mm Hg. Efaproxiral (150 mg/kg) increases tumor pO2 from 5.2 to 13.1 mm Hg 30 minutes after administration in a RIF-1 mouse fibrosarcoma flank tumor model. Efaproxiral (100 μM) enhances radiation-induced cytotoxicity in EMT6 mouse breast cancer cells grown under hypoxic conditions and increases radiosensitization and inhibits tumor growth in a hypoxic Lewis lung tumor mouse model when administered at a dose of 100 mg/kg. It also increases the running capacity of normal mice and mice with left coronary artery (LCA) ligation-induced myocardial infarction (MI) when administered at a dose of 150 mg/kg.

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