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ChemicalBook >> CAS DataBase List >> FR 122047 HYDROCHLORIDE

FR 122047 HYDROCHLORIDE

$36 - $1199.42
Product name: FR 122047 HYDROCHLORIDE
CAS: 130717-51-0
MF: C23H26ClN3O3S
MW: 459.99
EINECS:
MDL Number:MFCD00925604
Synonyms:4,5-BIS(4-METHOXYPHENYL-2-[(1-METHYLPIPERAZIN-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE;4,5-BIS(4-METHOXYPHENYL)-2-[(1-METHYLPIPERAZINE-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE;1-[[4,5-BIS(4-METHOXYPHENYL)-2-THIAZOLYL]CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE;1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE;FR 122047;FR 122047 HYDROCHLORIDE;FR122047HCl;(4,5-Bis(4-Methoxyphenyl)thiazol-2-yl)(4-Methylpiperazin-1-yl)Methanone hydrochloride

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Brand

aablocks
ACHEMBLOCK
AHH
AK Scientific
American Custom Chemicals Corporation
ApexBio Technology
Cayman Chemical
Chemenu
ChemScene
Sigma-Aldrich
Tocris
TRC
Usbiological

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5mg
10mg
0.025g
1mg
10
50
25mg
50mg
100mg

Manufactureraablocks
Product numberAA000US4
Product descriptionFR122047 (hydrochloride)
Packaging25mg
Price$308
Updated2026-05-25
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Manufactureraablocks
Product numberAA000US4
Product descriptionFR122047 (hydrochloride)
Packaging50mg
Price$483
Updated2026-05-25
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Manufactureraablocks
Product numberAA000US4
Product descriptionFR122047 (hydrochloride)
Packaging100mg
Price$681
Updated2026-05-25
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Manufactureraablocks
Product numberAA000US4
Product descriptionFR122047 (hydrochloride) ≥98%
Packaging10mg
Price$153
Updated2026-05-25
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Manufactureraablocks
Product numberAA000US4
Product descriptionFR122047 (hydrochloride) ≥98%
Packaging5mg
Price$86
Updated2026-05-25
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Manufactureraablocks
Product numberAA000US4
Product descriptionFR122047 (hydrochloride) ≥98%
Packaging1mg
Price$36
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product numberY227332
Product descriptionFR 122047 hydrochloride 97.00%
Packaging100MG
Price$990
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberY227332
Product descriptionFR 122047 hydrochloride 97.00%
Packaging25MG
Price$430
Updated2026-05-27
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ManufacturerAHH
Product numberMT-27372
Product description1-[[4,5-bis(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazine hydrochloride 97%
Packaging0.025g
Price$365
Updated2026-05-26
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ManufacturerAK Scientific
Product number1133AH
Product description1-[[4,5-Bis(4-methoxyphenyl)-2-thiazolyl]carbonyl]-4-methyl-piperazine,monohydrochloride,hydrate
Packaging5mg
Price$185
Updated2021-12-16
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ManufacturerAmerican Custom Chemicals Corporation
Product numberINB0001064
Product descriptionFR 122047 HYDROCHLORIDE 95.00%
Packaging50MG
Price$1199.42
Updated2021-12-16
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ManufacturerAmerican Custom Chemicals Corporation
Product numberINB0001064
Product descriptionFR 122047 HYDROCHLORIDE 95.00%
Packaging10MG
Price$702.19
Updated2021-12-16
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ManufacturerApexBio Technology
Product numberB6767
Product descriptionFR 122047 hydrochloride
Packaging50mg
Price$1050
Updated2026-05-06
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ManufacturerApexBio Technology
Product numberB6767
Product descriptionFR 122047 hydrochloride
Packaging10mg
Price$291
Updated2026-05-06
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ManufacturerCayman Chemical
Product number10039
Product descriptionFR122047 (hydrochloride) ≥98%
Packaging50mg
Price$667
Updated2026-04-30
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ManufacturerCayman Chemical
Product number10039
Product descriptionFR122047 (hydrochloride) ≥98%
Packaging1mg
Price$36
Updated2026-04-30
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA000US4	FR122047 (hydrochloride)	25mg	$308	2026-05-25	Buy
aablocks	AA000US4	FR122047 (hydrochloride)	50mg	$483	2026-05-25	Buy
aablocks	AA000US4	FR122047 (hydrochloride)	100mg	$681	2026-05-25	Buy
aablocks	AA000US4	FR122047 (hydrochloride) ≥98%	10mg	$153	2026-05-25	Buy
aablocks	AA000US4	FR122047 (hydrochloride) ≥98%	5mg	$86	2026-05-25	Buy
aablocks	AA000US4	FR122047 (hydrochloride) ≥98%	1mg	$36	2026-05-25	Buy
ACHEMBLOCK	Y227332	FR 122047 hydrochloride 97.00%	100MG	$990	2026-05-27	Buy
ACHEMBLOCK	Y227332	FR 122047 hydrochloride 97.00%	25MG	$430	2026-05-27	Buy
AHH	MT-27372	1-[[4,5-bis(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazine hydrochloride 97%	0.025g	$365	2026-05-26	Buy
AK Scientific	1133AH	1-[[4,5-Bis(4-methoxyphenyl)-2-thiazolyl]carbonyl]-4-methyl-piperazine,monohydrochloride,hydrate	5mg	$185	2021-12-16	Buy
American Custom Chemicals Corporation	INB0001064	FR 122047 HYDROCHLORIDE 95.00%	50MG	$1199.42	2021-12-16	Buy
American Custom Chemicals Corporation	INB0001064	FR 122047 HYDROCHLORIDE 95.00%	10MG	$702.19	2021-12-16	Buy
ApexBio Technology	B6767	FR 122047 hydrochloride	50mg	$1050	2026-05-06	Buy
ApexBio Technology	B6767	FR 122047 hydrochloride	10mg	$291	2026-05-06	Buy
Cayman Chemical	10039	FR122047 (hydrochloride) ≥98%	50mg	$667	2026-04-30	Buy
Cayman Chemical	10039	FR122047 (hydrochloride) ≥98%	1mg	$36	2026-04-30	Buy

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Properties

storage temp. :2-8°C
solubility :methylene chloride: 50 mg/mL, slightly hazy, yellow
form :powder
color :faint yellow
biological source :synthetic (organic)
Water Solubility :Soluble to 10 mM in water
InChI :1S/C23H25N3O3S.ClH/c1-25-12-14-26(15-13-25)23(27)22-24-20(16-4-8-18(28-2)9-5-16)21(30-22)17-6-10-19(29-3)11-7-17;/h4-11H,12-15H2,1-3H3;1H
InChIKey :YWMAVHIKOAOSFM-UHFFFAOYSA-N
SMILES :Cl[H].COc1ccc(cc1)-c2nc(sc2-c3ccc(OC)cc3)C(=O)N4CCN(C)CC4

Safety Information

Symbol(GHS):

Signal word:

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes

Precautionary statements:

Description

FR122047 is a selective inhibitor of COX-1. The IC₅₀ values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC₅₀ of 180-200 nM, which is nearly 100 times more potent than aspirin. Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.

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FR 122047 HYDROCHLORIDE

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Description

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