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ChemicalBook >> CAS DataBase List >> GDC-0032

GDC-0032

$14 - $17576
Product name: GDC-0032
CAS: 1282512-48-4
MF: C24H28N8O2
MW: 460.53
EINECS:
MDL Number:MFCD26142641
Synonyms:GDC-0032;RG7604/GDC-0032;4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-α,α-dimethyl-1H-pyrazole-1-acetamide;GDC-0032/(RG-7604);2-Methyl-2-[4-[2-(5-Methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroiMidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanaMide;4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-alpha,alpha-dimethyl-1H-pyrazole-1-acetamide;GDC-0032 4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-alpha,alpha-dimethyl-1H-pyrazole-1-acetamide;GDC-0032 (Taselisib)

Price74 Properties Safety Information Description

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aablocks
ACHEMBLOCK
Adipogen Life Sciences
AK Scientific
ApexBio Technology
Axon Medchem
Biorbyt Ltd
Biosynth
Cayman Chemical
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
TRC
Usbiological

Package

1mg
2mg
5mg
10mM(in1mLDMSO)
10mM(in 1mL DMSO)
10mg
10mM*1mLinDMSO
2x5mg
25MG
50mg
100mg
200mg
250mg
1.00g
1G
1000mg

Manufactureraablocks
Product numberAA000XTQ
Product description2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4]Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide 99%(HPLC)
Packaging10mg
Price$41
Updated2026-05-25
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Manufactureraablocks
Product numberAA000XTQ
Product description2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4]Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide 99
Packaging50mg
Price$186
Updated2026-05-25
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Manufactureraablocks
Product numberAA000XTQ
Product description2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4]Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide 99
Packaging100mg
Price$316
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000XTQ
Product description2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4]Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide 99
Packaging200mg
Price$460
Updated2026-05-25
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Manufactureraablocks
Product numberAA000XTQ
Product description2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4]Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide 99%(HPLC)
Packaging5mg
Price$29
Updated2026-05-25
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Manufactureraablocks
Product numberAA000XTQ
Product description2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4]Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide 99%(HPLC)
Packaging1mg
Price$14
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product numberP50900
Product descriptiontaselisib 98%
Packaging1G
Price$980
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product numberP50900
Product descriptiontaselisib 98%
Packaging1G
Price$980
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberP50900
Product descriptiontaselisib 98%
Packaging100MG
Price$160
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product numberP50900
Product descriptiontaselisib 98%
Packaging100MG
Price$160
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberP50900
Product descriptiontaselisib 98%
Packaging25MG
Price$60
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product numberP50900
Product descriptiontaselisib 98%
Packaging25MG
Price$60
Updated2026-05-27
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ManufacturerAdipogen Life Sciences
Product numberSYN-1202-M050
Product descriptionGDC-0032 ≥95%
Packaging50mg
Price$702
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberSYN-1202-M005
Product descriptionGDC-0032 ≥95%
Packaging5mg
Price$130
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberSYN-1202-M005
Product descriptionGDC-0032 ≥95%
Packaging5mg
Price$130
Updated2021-12-16
Buy

ManufacturerAdipogen Life Sciences
Product numberSYN-1202-M010
Product descriptionGDC-0032 ≥95%
Packaging10mg
Price$216
Updated2026-05-06
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA000XTQ	2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4]Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide 99%(HPLC)	10mg	$41	2026-05-25	Buy
aablocks	AA000XTQ	2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4]Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide 99	50mg	$186	2026-05-25	Buy
aablocks	AA000XTQ	2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4]Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide 99	100mg	$316	2026-05-25	Buy
aablocks	AA000XTQ	2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4]Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide 99	200mg	$460	2026-05-25	Buy
aablocks	AA000XTQ	2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4]Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide 99%(HPLC)	5mg	$29	2026-05-25	Buy
aablocks	AA000XTQ	2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4]Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide 99%(HPLC)	1mg	$14	2026-05-25	Buy
ACHEMBLOCK	P50900	taselisib 98%	1G	$980	2026-05-25	Buy
ACHEMBLOCK	P50900	taselisib 98%	1G	$980	2026-05-27	Buy
ACHEMBLOCK	P50900	taselisib 98%	100MG	$160	2026-05-25	Buy
ACHEMBLOCK	P50900	taselisib 98%	100MG	$160	2026-05-27	Buy
ACHEMBLOCK	P50900	taselisib 98%	25MG	$60	2026-05-25	Buy
ACHEMBLOCK	P50900	taselisib 98%	25MG	$60	2026-05-27	Buy
Adipogen Life Sciences	SYN-1202-M050	GDC-0032 ≥95%	50mg	$702	2026-05-06	Buy
Adipogen Life Sciences	SYN-1202-M005	GDC-0032 ≥95%	5mg	$130	2026-05-06	Buy
Adipogen Life Sciences	SYN-1202-M005	GDC-0032 ≥95%	5mg	$130	2021-12-16	Buy
Adipogen Life Sciences	SYN-1202-M010	GDC-0032 ≥95%	10mg	$216	2026-05-06	Buy

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Properties

Boiling point :783.3±70.0 °C(Predicted)
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥23.05 mg/mL in DMSO; insoluble in H2O; ≥2.79 mg/mL in EtOH with gentle warming
form :solid
pka :15.54±0.50(Predicted)
color :White to off-white

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P321	Specific treatment (see … on this label).
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P337+P313	IF eye irritation persists: Get medical advice/attention.
P403+P233	Store in a well-ventilated place. Keep container tightly closed.
P405	Store locked up.
P501	Dispose of contents/container to..…

Description

GDC-0032 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoforms α, δ, and γ (IC₅₀s = 0.28, 0.12, and 0.97 nM, respectively) that is 31 times less potent at PI3Kβ. It is over 1,000-fold selective for p100α over other PI3K-like kinases, including DNA-dependent protein kinase catalytic subunits, ATM, and ATR. GDC-0032 has increased potency in cancer cell lines harboring PIK3CA-activating alterations, and is effective in vivo, suppressing the growth of tumors in a mouse xenograft model at low drug dose levels.

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GDC-0032

Properties

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Description

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