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ChemicalBook >> CAS DataBase List >> GS 441524

GS 441524

$8 - $3781.25
Product name: GS 441524
CAS: 1191237-69-0
MF: C12H13N5O4
MW: 291.26
EINECS:200-001-8
MDL Number:MFCD32666994
Synonyms:2-C-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-2,5-ANHYDRO-3,4-O-(1-METHYLETHYLIDENE)-D-ALTRONONITRI;D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-;2-C-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-Altrononitrile;GS441525;(2R,3R,4S,5R)-2-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)TETRAHYDRO;GS-441524(EVO984);Remdesivir Impurity 6;S-441524

Price80 Properties Safety Information Description

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aablocks
ACHEMBLOCK
Adipogen Life Sciences
AK Scientific
Alichem
Ambeed
American Custom Chemicals Corporation
ApexBio Technology
Arctom
AvaChem
Biosynth
Cayman Chemical
ChemScene
DC Chemicals
Matrix Scientific
Medical Isotopes, Inc.
Synthonix
Tocris
TRC

Package

1mg
25mg
50mg
10mM(1mLinDMSO)
10mg
50
5mg
100mg
250mg
0.25g
500mg
1.00g
1g
5.00g
5g
10g
10.00g
25g

Manufactureraablocks
Product numberAA01FVYF
Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile ≥98%(HPLC)
Packaging5mg
Price$10
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01FVYF
Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 98%
Packaging100mg
Price$11
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01FVYF
Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile ≥98%(HPLC)
Packaging10mg
Price$11
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01FVYF
Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 98%
Packaging250mg
Price$16
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01FVYF
Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 98%
Packaging1g
Price$27
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01FVYF
Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 98%
Packaging5g
Price$108
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01FVYF
Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 98%
Packaging10g
Price$198
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01FVYF
Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 98%
Packaging25g
Price$453
Updated2026-05-30
Buy

ManufacturerACHEMBLOCK
Product numberU140425
Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 95%
Packaging25G
Price$375
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberU140425
Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 95%
Packaging5G
Price$125
Updated2026-05-27
Buy

ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3722-M050
Product descriptionGS-441524(RemdesivirMetabolite) ≥98%(HPLC)
Packaging50mg
Price$210
Updated2021-12-16
Buy

ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3722-M050
Product descriptionGS-441524 (Remdesivir Metabolite) ≥98%(HPLC)
Packaging50mg
Price$120
Updated2026-05-06
Buy

ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3722-M010
Product descriptionGS-441524 (Remdesivir Metabolite) ≥98%(HPLC)
Packaging10mg
Price$70
Updated2026-05-06
Buy

ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3722-M010
Product descriptionGS-441524(RemdesivirMetabolite) ≥98%(HPLC)
Packaging10mg
Price$80
Updated2021-12-16
Buy

ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3722-M005
Product descriptionGS-441524 (Remdesivir Metabolite) ≥98%(HPLC)
Packaging5mg
Price$45
Updated2026-05-06
Buy

ManufacturerAK Scientific
Product number0879AP
Product descriptionGS441524
Packaging25mg
Price$89
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA01FVYF	(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile ≥98%(HPLC)	5mg	$10	2026-05-30	Buy
aablocks	AA01FVYF	(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 98%	100mg	$11	2026-05-30	Buy
aablocks	AA01FVYF	(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile ≥98%(HPLC)	10mg	$11	2026-05-30	Buy
aablocks	AA01FVYF	(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 98%	250mg	$16	2026-05-30	Buy
aablocks	AA01FVYF	(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 98%	1g	$27	2026-05-30	Buy
aablocks	AA01FVYF	(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 98%	5g	$108	2026-05-30	Buy
aablocks	AA01FVYF	(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 98%	10g	$198	2026-05-30	Buy
aablocks	AA01FVYF	(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 98%	25g	$453	2026-05-30	Buy
ACHEMBLOCK	U140425	(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 95%	25G	$375	2026-05-27	Buy
ACHEMBLOCK	U140425	(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 95%	5G	$125	2026-05-27	Buy
Adipogen Life Sciences	AG-CR1-3722-M050	GS-441524(RemdesivirMetabolite) ≥98%(HPLC)	50mg	$210	2021-12-16	Buy
Adipogen Life Sciences	AG-CR1-3722-M050	GS-441524 (Remdesivir Metabolite) ≥98%(HPLC)	50mg	$120	2026-05-06	Buy
Adipogen Life Sciences	AG-CR1-3722-M010	GS-441524 (Remdesivir Metabolite) ≥98%(HPLC)	10mg	$70	2026-05-06	Buy
Adipogen Life Sciences	AG-CR1-3722-M010	GS-441524(RemdesivirMetabolite) ≥98%(HPLC)	10mg	$80	2021-12-16	Buy
Adipogen Life Sciences	AG-CR1-3722-M005	GS-441524 (Remdesivir Metabolite) ≥98%(HPLC)	5mg	$45	2026-05-06	Buy
AK Scientific	0879AP	GS441524	25mg	$89	2021-12-16	Buy

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Properties

Melting point :> 233° C (dec.)
Density :1.84±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
pka :12.13±0.70(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI :InChI=1/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/s3
InChIKey :BRDWIEOJOWJCLU-QHRJDZJMNA-N
SMILES :C([C@]1(C2=CC=C3C(=NC=NN23)N)[C@@H]([C@H](O)[C@@H](CO)O1)O)#N |&1:1,12,13,15,r|
CAS DataBase Reference :1191237-69-0

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

GS-441524 is the active prodrug of the broad-spectrum antiviral Remdesivir. GS-441524 is an adenosine nucleotide analog in viral RNA production. It is a nucleotide analog inhibitor of RNA-dependent RNA polymerases (RdRps). The compound interferes with the action of viral RNA polymerase and evades proofreading by viral exoribonuclease (ExoN), causing a decrease in viral RNA production (RNA synthesis arrest), either by terminating RNA chains or causing mutations. It inhibits MERS-CoV or SARS-CoV-infected HAE cultures (EC50=74nM and 69nM) and murine hepatitis virus (MHV) (EC50=30nM). In vivo, remdesivir (25 and 50 mg/kg) reduces lung viral titers and prevents weight loss in a mouse model of SARS-CoV infection. Remdesivir is used as a treatment for Ebola virus disease and Marburg virus infections and other single-stranded RNA viruses such as respiratory syncytial virus, Junin virus, Lassa fever virus, Nipah virus, Hendra virus and the coronaviruses (including MERS and SARS viruses). Remdesivir is effective in the control of 2019-nCoV (COVID-19) infection in vitro. It now also has been studied as a potential treatment for SARS-CoV-2 infections.

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Shaanxi Didu New Materials Co. Ltd

$1.50
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Hebei Dangtong Import and export Co LTD

$735.00
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GS 441524

Properties

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Description

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