GUGGULSTERONE E
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- $37 - $1989
- Product name: GUGGULSTERONE E
- CAS: 39025-24-6
- MF: C21H28O2
- MW: 312.45
- EINECS:
- MDL Number:MFCD01310758
- Synonyms:4,17(20)-(TRANS)-PREGNADIEN-3,16-DIONE;GS, TRANS;GUGGULESTERONE E;GUGGULSTERONE;GUGGULSTERONE E;GUGGULSTERONE (E FORM);TRANS-4,17(20)-PREGNADIENE-3,16-DIONE;TRANS-GUGGULSTERONE
49 prices
Selected condition：
Brand
- aablocks
- AK Scientific
- American Custom Chemicals Corporation
- Arctom
- AvaChem
- Biosynth
- Cayman Chemical
- ChemScene
- Sigma-Aldrich
- TRC
Package
- 5mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 10mg
- 20mg
- 25mg
- 50MG
- 100mg
- 0.5g
- 1g
- 2g
- 10mM*1mLinDMSO(Solution)
- Manufactureraablocks
- Product numberAA0076J0
- Product description(-)-(E)-Guggulsterone ≥98%
- Packaging10mg
- Price$332
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0076J0
- Product description(-)-(E)-Guggulsterone ≥98%
- Packaging25mg
- Price$775
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0076J0
- Product description(-)-(E)-Guggulsterone ≥98%
- Packaging5mg
- Price$178
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0076J0
- Product description(-)-(E)-Guggulsterone ≥98%
- Packaging1mg
- Price$41
- Updated2026-05-28
- Buy
- ManufacturerAK Scientific
- Product numberF676
- Product description(E)-Guggulsterone
- Packaging10mg
- Price$433
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002873
- Product descriptionGUGGULSTERONE E 95.00%
- Packaging50MG
- Price$1055.09
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002873
- Product descriptionGUGGULSTERONE E 95.00%
- Packaging10MG
- Price$698.54
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002873
- Product descriptionGUGGULSTERONE E 95.00%
- Packaging5MG
- Price$660.66
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-N7781
- Product description(-)-(E)-Guggulsterone 99.19%
- Packaging100mg
- Price$1140
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-N7781R
- Product description(-)-(E)-Guggulsterone (Standard) 98%
- Packaging50mg
- Price$1374
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-N7781R
- Product description(-)-(E)-Guggulsterone (Standard) 98%
- Packaging25mg
- Price$916
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-N7781
- Product description(-)-(E)-Guggulsterone 99.19%
- Packaging10mM*1mLinDMSO(Solution)
- Price$168
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-N7781
- Product description(-)-(E)-Guggulsterone 99.19%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$159
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-N7781
- Product description(-)-(E)-Guggulsterone 99.19%
- Packaging5mg
- Price$152
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-N7781
- Product description(-)-(E)-Guggulsterone 99.19%
- Packaging50mg
- Price$732
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-N7781
- Product description(-)-(E)-Guggulsterone 99.19%
- Packaging25mg
- Price$456
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0076J0 | (-)-(E)-Guggulsterone ≥98% | 10mg | $332 | 2026-05-28 | Buy |
| aablocks | AA0076J0 | (-)-(E)-Guggulsterone ≥98% | 25mg | $775 | 2026-05-28 | Buy |
| aablocks | AA0076J0 | (-)-(E)-Guggulsterone ≥98% | 5mg | $178 | 2026-05-28 | Buy |
| aablocks | AA0076J0 | (-)-(E)-Guggulsterone ≥98% | 1mg | $41 | 2026-05-28 | Buy |
| AK Scientific | F676 | (E)-Guggulsterone | 10mg | $433 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002873 | GUGGULSTERONE E 95.00% | 50MG | $1055.09 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002873 | GUGGULSTERONE E 95.00% | 10MG | $698.54 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002873 | GUGGULSTERONE E 95.00% | 5MG | $660.66 | 2021-12-16 | Buy |
| Arctom | HY-N7781 | (-)-(E)-Guggulsterone 99.19% | 100mg | $1140 | 2026-05-26 | Buy |
| Arctom | HY-N7781R | (-)-(E)-Guggulsterone (Standard) 98% | 50mg | $1374 | 2026-05-26 | Buy |
| Arctom | HY-N7781R | (-)-(E)-Guggulsterone (Standard) 98% | 25mg | $916 | 2026-05-26 | Buy |
| Arctom | HY-N7781 | (-)-(E)-Guggulsterone 99.19% | 10mM*1mLinDMSO(Solution) | $168 | 2026-05-26 | Buy |
| Arctom | HY-N7781 | (-)-(E)-Guggulsterone 99.19% | 10mM*1mLinDMSO(Solid+Solvent) | $159 | 2026-05-26 | Buy |
| Arctom | HY-N7781 | (-)-(E)-Guggulsterone 99.19% | 5mg | $152 | 2026-05-26 | Buy |
| Arctom | HY-N7781 | (-)-(E)-Guggulsterone 99.19% | 50mg | $732 | 2026-05-26 | Buy |
| Arctom | HY-N7781 | (-)-(E)-Guggulsterone 99.19% | 25mg | $456 | 2026-05-26 | Buy |
Properties
Melting point :170-171.5°
alpha :D26 -30° (c = 1 in chloroform)
Boiling point :463℃
Density :1.10
Flash point :172℃
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL
form :powder
color :white to off-white
InChI :InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4-/t15-,17+,18+,20+,21-/m1/s1
InChIKey :WDXRGPWQVHZTQJ-AUKWTSKRSA-N
SMILES :C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)/C(=C\C)/C(=O)C3)CC2
LogP :3.650 (est)
alpha :D26 -30° (c = 1 in chloroform)
Boiling point :463℃
Density :1.10
Flash point :172℃
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL
form :powder
color :white to off-white
InChI :InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4-/t15-,17+,18+,20+,21-/m1/s1
InChIKey :WDXRGPWQVHZTQJ-AUKWTSKRSA-N
SMILES :C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)/C(=C\C)/C(=O)C3)CC2
LogP :3.650 (est)
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
| Hazard statements: |
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| Precautionary statements: |
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Description
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism. They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress. Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis. Guggulsterone, derived from resin of the guggul tree, is a competitive antagonist of FXR both in vitro and in vivo. The cis stereoisomer of guggulsterone, (E)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50 value of 15 M. By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet.More related product prices
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Suppliers and manufacturers
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Suzhou ARTK Medchem Co., Ltd.
Mensura Group Limited
(E)-Guggulsterone
CAS:39025-24-6