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ChemicalBook >> CAS DataBase List >> HTH-01-015

HTH-01-015

HTH-01-015 price.
  • $50 - $1300
  • Product name: HTH-01-015
  • CAS: 1613724-42-7
  • MF: C26H28N8O
  • MW: 468.55
  • EINECS:
  • MDL Number:MFCD28167816
  • Synonyms:HTH-01-015;5,13-Dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one;HTH-01-015 >=98% (HPLC);6H-Naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one, 5,13-dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-;CHSDJDLAKKAWCI-UHFFFAOYSA-N;CS-2296;inhibit,AMPK,AMP-activated protein kinase,HTH 01 015,HTH01015,Inhibitor;4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one
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  • aablocks
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  • AK Scientific
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  • American Custom Chemicals Corporation
  • ApexBio Technology
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  • Cayman Chemical
  • ChemScene
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Package
  • 100.00mg
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  • 10mM*1mLinDMSO
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  • 10mM*1mLinDMSO(Solid+Solvent)
  • Manufactureraablocks
  • Product numberAA001SBF
  • Product description4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one 98
  • Packaging1mg
  • Price$50
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA001SBF
  • Product description4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one 98
  • Packaging2mg
  • Price$60
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA001SBF
  • Product description4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one 98
  • Packaging5mg
  • Price$78
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA001SBF
  • Product description4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one 98
  • Packaging10mg
  • Price$107
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA001SBF
  • Product description4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one 98%
  • Packaging50mg
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  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA001SBF
  • Product description4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one 98%
  • Packaging100mg
  • Price$204
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberM22564
  • Product descriptionHTH-01-015 98%
  • Packaging25MG
  • Price$125
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberM22564
  • Product descriptionHTH-01-015 98%
  • Packaging100MG
  • Price$325
  • Updated2026-05-27
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  • ManufacturerAK Scientific
  • Product number1510DY
  • Product description2,7,9-Trimethyl-5-[(1-piperidin-4-ylpyrazol-4-yl)amino]-2,4,6,9-tetrazatetracyclo[9.8.0.03,8.013,18]nonadeca-1(19),3,5,7,11,13,15,17-octaen-10-one
  • Packaging1mg
  • Price$179
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA321152
  • Product description4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one 98+%
  • Packaging5mg
  • Price$65
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0009804
  • Product descriptionHTH 01-015 95.00%
  • Packaging5MG
  • Price$457.31
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA8890
  • Product descriptionHTH-01-015
  • Packaging50mg
  • Price$358
  • Updated2026-05-06
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  • ManufacturerApexBio Technology
  • Product numberA8890
  • Product descriptionHTH-01-015
  • Packaging10mg
  • Price$118
  • Updated2026-05-06
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  • ManufacturerApexBio Technology
  • Product numberA8890
  • Product descriptionHTH-01-015
  • Packaging10mg
  • Price$118
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8890
  • Product descriptionHTH-01-015
  • Packaging100mg
  • Price$480
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8890
  • Product descriptionHTH-01-015
  • Packaging10mM(in1mLDMSO)
  • Price$110
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA001SBF 4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one 98 1mg $50 2026-05-28 Buy
aablocks AA001SBF 4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one 98 2mg $60 2026-05-28 Buy
aablocks AA001SBF 4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one 98 5mg $78 2026-05-28 Buy
aablocks AA001SBF 4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one 98 10mg $107 2026-05-28 Buy
aablocks AA001SBF 4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one 98% 50mg $110 2026-05-28 Buy
aablocks AA001SBF 4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one 98% 100mg $204 2026-05-28 Buy
ACHEMBLOCK M22564 HTH-01-015 98% 25MG $125 2026-05-27 Buy
ACHEMBLOCK M22564 HTH-01-015 98% 100MG $325 2026-05-27 Buy
AK Scientific 1510DY 2,7,9-Trimethyl-5-[(1-piperidin-4-ylpyrazol-4-yl)amino]-2,4,6,9-tetrazatetracyclo[9.8.0.03,8.013,18]nonadeca-1(19),3,5,7,11,13,15,17-octaen-10-one 1mg $179 2021-12-16 Buy
Ambeed A321152 4,5,13-Trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one 98+% 5mg $65 2021-12-16 Buy
American Custom Chemicals Corporation INB0009804 HTH 01-015 95.00% 5MG $457.31 2021-12-16 Buy
ApexBio Technology A8890 HTH-01-015 50mg $358 2026-05-06 Buy
ApexBio Technology A8890 HTH-01-015 10mg $118 2026-05-06 Buy
ApexBio Technology A8890 HTH-01-015 10mg $118 2021-12-16 Buy
ApexBio Technology A8890 HTH-01-015 100mg $480 2026-05-06 Buy
ApexBio Technology A8890 HTH-01-015 10mM(in1mLDMSO) $110 2026-05-06 Buy

Properties

Boiling point :759.6±70.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥23.45 mg/mL in DMSO; insoluble in H2O; ≥14.67 mg/mL in EtOH with ultrasonic
pka :9.84±0.10(Predicted)
form :powder
color :white to light brown
InChIKey :CHSDJDLAKKAWCI-UHFFFAOYSA-N
SMILES :CC1=C2C(N(C)C(C=C(C=CC=C3)C3=C4)=C4C(N2C)=O)=NC(NC5=CN(C6CCNCC6)N=C5)=N1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

NUAK1 (also known as AMPK-related kinase 5) and NUAK2 (also known as SNF1/AMPK-related kinase) are members of the AMP-activated protein kinase (AMPK) family of protein kinases that are activated by the liver kinase B1 tumor suppressor kinase. NUAK kinases are thought to have roles in regulating cell adhesion, cancer cell invasion, embryonic development, senescence, proliferation, neuronal polarity, and axon branching. HTH-01-015 is a selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. At 10 μM, HTH-01-015 has been shown to partially inhibit the phosphorylation of the NUAK1 substrate, myosin phosphate-targeting subunit 1 at Ser445. When administered to mouse embryonic fibroblasts in vitro, 10 μM HTH-01-015 inhibits proliferation and migration in a wound-healing assay. It has also been shown to impair the invasive potential of U2OS cells at similar concentrations in a 3D cell invasion assay.

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