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ChemicalBook >> CAS DataBase List >> I-BET151 (GSK1210151A)

I-BET151 (GSK1210151A)

I-BET151 (GSK1210151A) price.
  • $36 - $3876
  • Product name: I-BET151 (GSK1210151A)
  • CAS: 1300031-49-5
  • MF: C23H21N5O3
  • MW: 415.44
  • EINECS:
  • MDL Number:MFCD22124472
  • Synonyms:7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one;I-BET 151/GSK 1210151A;GSK1210151A (I-BET151);7-(3,5-diMethylisoxazol-4-yl)-8-Methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-iMidazo[4,5-c]quinolin-2(3H)-one;7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2;GSK 1210151A;I-BET 151;7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one I-BET151(GSK1210151A)
67 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 10mM*1mLinDMSO
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 25MG
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 25 mg
  • Manufactureraablocks
  • Product numberAA000TTH
  • Product description7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one ≥98%
  • Packaging1mg
  • Price$40
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000TTH
  • Product description7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one 98%
  • Packaging5mg
  • Price$64
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000TTH
  • Product description7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one 98%
  • Packaging10mg
  • Price$76
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000TTH
  • Product description7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one 98%
  • Packaging50mg
  • Price$229
  • Updated2026-05-25
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  • Manufactureraablocks
  • Product numberAA000TTH
  • Product description7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one
  • Packaging100mg
  • Price$447
  • Updated2026-05-25
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  • ManufacturerACHEMBLOCK
  • Product number10331
  • Product descriptionI-BET151 98%
  • Packaging100MG
  • Price$640
  • Updated2026-05-25
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  • ManufacturerACHEMBLOCK
  • Product number10331
  • Product descriptionI-BET151 98%
  • Packaging100MG
  • Price$640
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10331
  • Product descriptionI-BET151 98%
  • Packaging25MG
  • Price$255
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10331
  • Product descriptionI-BET151 98%
  • Packaging25MG
  • Price$255
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10331
  • Product descriptionI-BET151 98%
  • Packaging10MG
  • Price$140
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10331
  • Product descriptionI-BET151 98%
  • Packaging10MG
  • Price$140
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product numberX5823
  • Product descriptionGSK1210151A
  • Packaging50mg
  • Price$604
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1500
  • Product descriptionI-BET151(GSK1210151A)
  • Packaging100mg
  • Price$630
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1500
  • Product descriptionI-BET151 (GSK1210151A)
  • Packaging100mg
  • Price$630
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1500
  • Product descriptionI-BET151(GSK1210151A)
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1500
  • Product descriptionI-BET151 (GSK1210151A)
  • Packaging10mg
  • Price$120
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA000TTH 7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one ≥98% 1mg $40 2026-05-25 Buy
aablocks AA000TTH 7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one 98% 5mg $64 2026-05-25 Buy
aablocks AA000TTH 7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one 98% 10mg $76 2026-05-25 Buy
aablocks AA000TTH 7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one 98% 50mg $229 2026-05-25 Buy
aablocks AA000TTH 7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one 100mg $447 2026-05-25 Buy
ACHEMBLOCK 10331 I-BET151 98% 100MG $640 2026-05-25 Buy
ACHEMBLOCK 10331 I-BET151 98% 100MG $640 2026-05-27 Buy
ACHEMBLOCK 10331 I-BET151 98% 25MG $255 2026-05-25 Buy
ACHEMBLOCK 10331 I-BET151 98% 25MG $255 2026-05-27 Buy
ACHEMBLOCK 10331 I-BET151 98% 10MG $140 2026-05-25 Buy
ACHEMBLOCK 10331 I-BET151 98% 10MG $140 2026-05-27 Buy
AK Scientific X5823 GSK1210151A 50mg $604 2021-12-16 Buy
ApexBio Technology B1500 I-BET151(GSK1210151A) 100mg $630 2021-12-16 Buy
ApexBio Technology B1500 I-BET151 (GSK1210151A) 100mg $630 2026-05-06 Buy
ApexBio Technology B1500 I-BET151(GSK1210151A) 10mg $120 2021-12-16 Buy
ApexBio Technology B1500 I-BET151 (GSK1210151A) 10mg $120 2026-05-06 Buy

Properties

Density :1.314
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :11.14±0.20(Predicted)
color :white to beige
InChI :InChI=1S/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/m1/s1
InChIKey :VUVUVNZRUGEAHB-CYBMUJFWSA-N
SMILES :N1C2C(=CC(OC)=C(C3=C(C)ON=C3C)C=2)C2N([C@@H](C3=NC=CC=C3)C)C(=O)NC=2C=1

Safety Information

Symbol(GHS): Skull and Crossbones (GHS06)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

The bromodomain and extra terminal domain (BET) family of proteins including BRD2, BRD3, and BRD4 play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. I-BET151 is an isoxazole class pan-BET family inhibitor, blocking BRD2, BRD3, and BRD4 with IC50 values of 0.5, 0.25, and 0.79 μM, respectively. Through this action, it blocks the growth of leukemic cell lines driven by mixed lineage leukemia (MLL) fusions at nanomolar concentrations, whereas tyrosine kinase activated cells were much less sensitive. Specifically, I-BET151 induces apoptosis via reduced expression of BCL2 or triggers G0/G1 cell cycle arrest in MLL-fusion cell lines. I-BET151 is effective in vivo, suppressing MLL leukemia progression in two different mouse models.
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