K-252A
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- $50 - $6795
- Product name: K-252A
- CAS: 99533-80-9
- MF: C27H21N3O5
- MW: 467.47
- EINECS:640-127-4
- MDL Number:MFCD09878276
- Synonyms:(9-alpha,10-beta,12-alpha)-este ;[9S,(+)]-2,3,9,10,11,12-Hexahydro-10α-hydroxy-9-methyl-1-oxo-9β,12β-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester;9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-;9,1-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9-alpha,10-beta,12-alpha)-;(9α,10β,12α)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-Methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid Methyl ester;K 252a(SF 2370);2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-0-carboxylicacimethyl ;9,1-epoxy-1h-diindolo(1,2,3-fg:3’,2’,1’-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1
64 prices
Selected condition：
Brand
- aablocks
- Adipogen Life Sciences
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Biosynth
- Cayman Chemical
- ChemScene
- Sigma-Aldrich
- Thermo Scientific Chemicals
- TRC
- Usbiological
Package
- 100UG-F
- 200ug
- 0.5mg
- 1mg
- 2mg
- 250mg
- 500mg
- 1g
- 200μL
- 100ug
- 100μg
- 10mg
- 10mM*1mLinDMSO(Solution)
- 5mg
- 25mg
- 100mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 50mg
- Manufactureraablocks
- Product numberAA006530
- Product description9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S,10R,12R) ≥98%
- Packaging1mg
- Price$63
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006530
- Product description9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S,10R,12R) ≥98%
- Packaging5mg
- Price$229
- Updated2026-05-28
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0019-C100
- Product descriptionK-252a ≥98%(HPLC)
- Packaging100μg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0019-M001
- Product descriptionK-252a ≥98%(HPLC)
- Packaging1mg
- Price$120
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0019-C100
- Product descriptionK-252a ≥98%(HPLC)
- Packaging100μg
- Price$60
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6828
- Product descriptionK252a
- Packaging1mg
- Price$520
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6828
- Product descriptionK 252a
- Packaging5mg
- Price$795
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6828
- Product descriptionK252a
- Packaging5mg
- Price$1559
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6828
- Product descriptionK 252a
- Packaging1mg
- Price$220
- Updated2026-05-06
- Buy
- ManufacturerApolloscientific
- Product numberBIK1001
- Product descriptionK252a
- Packaging1mg
- Price$83
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIK1001
- Product descriptionK252a
- Packaging5mg
- Price$317
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIK1001
- Product descriptionK252a
- Packaging50mg
- Price$2308
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIK1001
- Product descriptionK252a
- Packaging25mg
- Price$1272
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIK1001
- Product descriptionK252a
- Packaging10mg
- Price$576
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIK1001
- Product descriptionK252a
- Packaging100mg
- Price$4187
- Updated2026-06-04
- Buy
- ManufacturerArctom
- Product numberHY-N6732
- Product descriptionK-252a 99.02%
- Packaging1mg
- Price$133
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA006530 | 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S,10R,12R) ≥98% | 1mg | $63 | 2026-05-28 | Buy |
| aablocks | AA006530 | 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S,10R,12R) ≥98% | 5mg | $229 | 2026-05-28 | Buy |
| Adipogen Life Sciences | AG-CN2-0019-C100 | K-252a ≥98%(HPLC) | 100μg | $60 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CN2-0019-M001 | K-252a ≥98%(HPLC) | 1mg | $120 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CN2-0019-C100 | K-252a ≥98%(HPLC) | 100μg | $60 | 2026-05-06 | Buy |
| ApexBio Technology | B6828 | K252a | 1mg | $520 | 2021-12-16 | Buy |
| ApexBio Technology | B6828 | K 252a | 5mg | $795 | 2026-05-06 | Buy |
| ApexBio Technology | B6828 | K252a | 5mg | $1559 | 2021-12-16 | Buy |
| ApexBio Technology | B6828 | K 252a | 1mg | $220 | 2026-05-06 | Buy |
| Apolloscientific | BIK1001 | K252a | 1mg | $83 | 2026-06-04 | Buy |
| Apolloscientific | BIK1001 | K252a | 5mg | $317 | 2026-06-04 | Buy |
| Apolloscientific | BIK1001 | K252a | 50mg | $2308 | 2026-06-04 | Buy |
| Apolloscientific | BIK1001 | K252a | 25mg | $1272 | 2026-06-04 | Buy |
| Apolloscientific | BIK1001 | K252a | 10mg | $576 | 2026-06-04 | Buy |
| Apolloscientific | BIK1001 | K252a | 100mg | $4187 | 2026-06-04 | Buy |
| Arctom | HY-N6732 | K-252a 99.02% | 1mg | $133 | 2026-05-26 | Buy |
Properties
Melting point :262-273℃ (decomposition) (methanol )
Boiling point :685.3±55.0 °C(Predicted)
Density :1.68
Flash point :87℃
storage temp. :-20°C
solubility :DMF: 1 mg/mL
pka :11.95±0.40(Predicted)
form :Lyophilized solid.
color :White or off-white
biological source :Nonomuraea longicatena
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :KOZFSFOOLUUIGY-SOLYNIJKSA-N
SMILES :[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
Boiling point :685.3±55.0 °C(Predicted)
Density :1.68
Flash point :87℃
storage temp. :-20°C
solubility :DMF: 1 mg/mL
pka :11.95±0.40(Predicted)
form :Lyophilized solid.
color :White or off-white
biological source :Nonomuraea longicatena
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :KOZFSFOOLUUIGY-SOLYNIJKSA-N
SMILES :[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
K252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi that inhibits protein kinase (PK) C, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase with IC50 values of 470, 140, 270, and 1.7 nM, respectively. Because it inhibits neurotrophin receptor tyrosine kinases, K252a at 100-500 nM has been used to suppress trophoblast proliferation and increase apoptosis associated with the disruption of mitochondrial functions in cultured choriocarcinoma cells. Recently, K252a has been shown to inhibit PRK1 (IC50 = 3.2 nM in vitro), a PKC-related kinase that phosphorylates histone H3 at threonine 11 and is involved in androgen-dependent gene expression.Related product price
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