Lestaurtinib
|
- $44 - $1200
- Product name: Lestaurtinib
- CAS: 111358-88-4
- MF: C26H21N3O4
- MW: 439.47
- EINECS:
- MDL Number:MFCD09840836
- Synonyms:lestaurtinib;(9S-(9α,10β,12α))-2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxyMethyl)-9-Methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one;SPM-924;CEP-701 hydrate;KT-5555 hydrate;Lestaurtinib hydrate; A 154475.0;(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:321kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
46 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- AvaChem
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1ug
- 50
- 500μg
- 500ug
- 1
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- Manufactureraablocks
- Product numberAA007AV7
- Product description(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one ≥98%
- Packaging1mg
- Price$77
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007AV7
- Product description(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one ≥98%
- Packaging5mg
- Price$167
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007AV7
- Product description(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one ≥98%
- Packaging10mg
- Price$283
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD264305
- Product descriptionLestaurtinib 98%
- Packaging1MG
- Price$270
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD264305
- Product descriptionLestaurtinib 98%
- Packaging5MG
- Price$945
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberV0246
- Product descriptionLestaurtinib
- Packaging5mg
- Price$266
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberV0246
- Product descriptionLestaurtinib
- Packaging1mg
- Price$175
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001285
- Product descriptionCEP-701 HYDRATE 95.00%
- Packaging1MG
- Price$674.9
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001285
- Product descriptionCEP-701 HYDRATE 95.00%
- Packaging5MG
- Price$1113.6
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4513
- Product descriptionLestaurtinib
- Packaging10mg
- Price$360
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4513
- Product descriptionLestaurtinib
- Packaging1mg
- Price$385
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4513
- Product descriptionLestaurtinib
- Packaging5mg
- Price$212
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4513
- Product descriptionLestaurtinib
- Packaging1mg
- Price$98
- Updated2026-05-06
- Buy
- ManufacturerApolloscientific
- Product numberBIL2000
- Product descriptionLestaurtinib
- Packaging1mg
- Price$209
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIL2000
- Product descriptionLestaurtinib
- Packaging5mg
- Price$666
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIL2000
- Product descriptionLestaurtinib
- Packaging10mg
- Price$1156
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA007AV7 | (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one ≥98% | 1mg | $77 | 2026-05-28 | Buy |
| aablocks | AA007AV7 | (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one ≥98% | 5mg | $167 | 2026-05-28 | Buy |
| aablocks | AA007AV7 | (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one ≥98% | 10mg | $283 | 2026-05-28 | Buy |
| ACHEMBLOCK | AD264305 | Lestaurtinib 98% | 1MG | $270 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD264305 | Lestaurtinib 98% | 5MG | $945 | 2026-05-27 | Buy |
| AK Scientific | V0246 | Lestaurtinib | 5mg | $266 | 2021-12-16 | Buy |
| AK Scientific | V0246 | Lestaurtinib | 1mg | $175 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001285 | CEP-701 HYDRATE 95.00% | 1MG | $674.9 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001285 | CEP-701 HYDRATE 95.00% | 5MG | $1113.6 | 2021-12-16 | Buy |
| ApexBio Technology | A4513 | Lestaurtinib | 10mg | $360 | 2026-05-06 | Buy |
| ApexBio Technology | A4513 | Lestaurtinib | 1mg | $385 | 2021-12-16 | Buy |
| ApexBio Technology | A4513 | Lestaurtinib | 5mg | $212 | 2026-05-06 | Buy |
| ApexBio Technology | A4513 | Lestaurtinib | 1mg | $98 | 2026-05-06 | Buy |
| Apolloscientific | BIL2000 | Lestaurtinib | 1mg | $209 | 2021-12-16 | Buy |
| Apolloscientific | BIL2000 | Lestaurtinib | 5mg | $666 | 2021-12-16 | Buy |
| Apolloscientific | BIL2000 | Lestaurtinib | 10mg | $1156 | 2021-12-16 | Buy |
Properties
Melting point :215-220°C
Boiling point :723.0±60.0 °C(Predicted)
Density :1.70±0.1 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :DMSO: >10mg/mL
form :white powder
pka :13.37±0.40(Predicted)
color :White or off-white
Stability :Photosensitive
InChIKey :LPOQWFBZBJTLEO-GMEYHWBASA-N
SMILES :O.C[C@]12O[C@H](C[C@]1(O)CO)n3c4ccccc4c5c6C(=O)NCc6c7c8ccccc8n2c7c35
Boiling point :723.0±60.0 °C(Predicted)
Density :1.70±0.1 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :DMSO: >10mg/mL
form :white powder
pka :13.37±0.40(Predicted)
color :White or off-white
Stability :Photosensitive
InChIKey :LPOQWFBZBJTLEO-GMEYHWBASA-N
SMILES :O.C[C@]12O[C@H](C[C@]1(O)CO)n3c4ccccc4c5c6C(=O)NCc6c7c8ccccc8n2c7c35
Safety Information
| Symbol(GHS): |
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative disorders. Lestaurtinib is a staurosporine analog that potently inhibits JAK2 kinase (IC50 = 1 nM) and downstream targets STAT5 (IC50 = 10-30 nM) and STAT3 in a human erythroleukemic cell line expressing the JAK2V617F mutation. It has been used to reduce tumor growth in a xenograft model of pancreatic ductal adenocarcinoma, to inhibit cell growth in a trk-B overexpressing neuroblastoma xenograft model, and to block proliferation and induce apoptosis in Hodgkin lymphoma cell lines. Lestaurtinib has since been reported to potently inhibit the epigenetic kinase PRK1 in vitro (IC50 = 8.6 nM), inducing hypophosphorylation of histone H3 threonine 11 and blocking androgen-dependent gene expression in prostate cancer cells at a concentration of 5 μM.Related product price
-
Dasatinib monohydrate
$8-1342 -
Imatinib
$5-1490.64 -
Gefitinib
$5-1141
Suppliers and manufacturers
HANGZHOU CLAP TECHNOLOGY CO.,LTD
BOC Sciences
Hangzhou Proserre Chemical Co.,Ltd.
Hefei TNJ Chemical Industry Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
Nanjing Fred Technology Co., Ltd
Shanghai Acmec Biochemical Technology Co., Ltd.
