MK8245
|
- $32 - $2244
- Product name: MK8245
- CAS: 1030612-90-8
- MF: C17H16BrFN6O4
- MW: 467.25
- EINECS:
- MDL Number:MFCD20039622
- Synonyms:5-[3-[4-(2-Bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid;2-(5-(3-(4-(2-broMo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid;MK 8245;MK8245;MK8245;MK-8245;MK 8245;CS-1662;]-2H-tetrazoL;]-5-isoxazoL;5-[3-[4-(2-Bromo-5-fL
80 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
Package
- 10mM(in1mLDMSO)
- 1mg
- 10mM(1mLinDMSO)
- 2mg
- 5mg
- 10mg
- 10mM*1mLinDMSO
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA008TFH
- Product descriptionMK-8245 99%
- Packaging1mg
- Price$32
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TFH
- Product descriptionMK-8245 99%
- Packaging2mg
- Price$38
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TFH
- Product descriptionMK-8245 99%
- Packaging5mg
- Price$70
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TFH
- Product descriptionMK-8245 99%
- Packaging10mg
- Price$111
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TFH
- Product descriptionMK-8245 99%
- Packaging25mg
- Price$161
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TFH
- Product descriptionMK-8245 99%
- Packaging50mg
- Price$193
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TFH
- Product descriptionMK-8245 99%
- Packaging100mg
- Price$385
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TFH
- Product descriptionMK-8245 98%
- Packaging250mg
- Price$815
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TFH
- Product descriptionMK-8245 98%
- Packaging1g
- Price$2244
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15370
- Product descriptionMK-8245 98%
- Packaging1G
- Price$850
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15370
- Product descriptionMK-8245 98%
- Packaging1G
- Price$850
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15370
- Product descriptionMK-8245 98%
- Packaging100MG
- Price$275
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15370
- Product descriptionMK-8245 98%
- Packaging100MG
- Price$275
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15370
- Product descriptionMK-8245 98%
- Packaging25MG
- Price$95
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15370
- Product descriptionMK-8245 98%
- Packaging25MG
- Price$95
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15370
- Product descriptionMK-8245 98%
- Packaging5MG
- Price$35
- Updated2026-05-25
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA008TFH | MK-8245 99% | 1mg | $32 | 2026-05-28 | Buy |
| aablocks | AA008TFH | MK-8245 99% | 2mg | $38 | 2026-05-28 | Buy |
| aablocks | AA008TFH | MK-8245 99% | 5mg | $70 | 2026-05-28 | Buy |
| aablocks | AA008TFH | MK-8245 99% | 10mg | $111 | 2026-05-28 | Buy |
| aablocks | AA008TFH | MK-8245 99% | 25mg | $161 | 2026-05-28 | Buy |
| aablocks | AA008TFH | MK-8245 99% | 50mg | $193 | 2026-05-28 | Buy |
| aablocks | AA008TFH | MK-8245 99% | 100mg | $385 | 2026-05-28 | Buy |
| aablocks | AA008TFH | MK-8245 98% | 250mg | $815 | 2026-05-28 | Buy |
| aablocks | AA008TFH | MK-8245 98% | 1g | $2244 | 2026-05-28 | Buy |
| ACHEMBLOCK | M15370 | MK-8245 98% | 1G | $850 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15370 | MK-8245 98% | 1G | $850 | 2026-05-25 | Buy |
| ACHEMBLOCK | M15370 | MK-8245 98% | 100MG | $275 | 2026-05-25 | Buy |
| ACHEMBLOCK | M15370 | MK-8245 98% | 100MG | $275 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15370 | MK-8245 98% | 25MG | $95 | 2026-05-25 | Buy |
| ACHEMBLOCK | M15370 | MK-8245 98% | 25MG | $95 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15370 | MK-8245 98% | 5MG | $35 | 2026-05-25 | Buy |
Properties
Boiling point :698.3±65.0 °C(Predicted)
Density :1.82
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :≥23.35 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :solid
pka :2.85±0.10(Predicted)
color :White to off-white
InChI :1S/C17H16BrFN6O4/c18-12-2-1-10(19)7-13(12)28-11-3-5-24(6-4-11)15-8-14(29-22-15)17-20-23-25(21-17)9-16(26)27/h1-2,7-8,11H,3-6,9H2,(H,26,27)
InChIKey :UJEAABFSXKCSGI-UHFFFAOYSA-N
SMILES :Fc1cc(c(cc1)Br)OC2CCN(CC2)c3n[o]c(c3)c4n[n](nn4)CC(=O)O
Density :1.82
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :≥23.35 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :solid
pka :2.85±0.10(Predicted)
color :White to off-white
InChI :1S/C17H16BrFN6O4/c18-12-2-1-10(19)7-13(12)28-11-3-5-24(6-4-11)15-8-14(29-22-15)17-20-23-25(21-17)9-16(26)27/h1-2,7-8,11H,3-6,9H2,(H,26,27)
InChIKey :UJEAABFSXKCSGI-UHFFFAOYSA-N
SMILES :Fc1cc(c(cc1)Br)OC2CCN(CC2)c3n[o]c(c3)c4n[n](nn4)CC(=O)O
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
MK-8245 is a liver-targeted inhibitor of stearoyl-CoA desaturase (SCD; IC50s = 3, 3, and 1 nM for rat, mouse, and human SCD1, respectively). It is selective for SCD1 over Δ5- and Δ6-desaturases (IC50s = >100,000 nM). MK-8245 (20-60 mg/kg) reduces the hepatic, but not Harderian gland, ratio of oleic acid to stearic acid, a marker of chronic SCD activity, and blood glucose levels, without inducing the formation of skin lesions or eye squinting behavior, in a mouse model of high-fat diet-induced obesity. It also inhibits hepatitis C virus (HCV) replication without inducing cytotoxicity in LucNeo2 cells (IC50 = 39.8 nM).Related product price
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