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ChemicalBook >> CAS DataBase List >> MonoMethyl auristatin E

MonoMethyl auristatin E

MonoMethyl auristatin E price.
  • $10 - $3772
  • Product name: MonoMethyl auristatin E
  • CAS: 474645-27-7
  • MF: C39H67N5O7
  • MW: 717.98
  • EINECS:
  • MDL Number:MFCD22124498
  • Synonyms:MonoMethyl auristatin E(MMAE, vedotin);HM-297C-22;MonoMethyl auristatin E;Monomethyl auristatin E, >=98%;MMAE(Monomethyl auristatin E);(2S)-N-[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide;[3H]-Vedotin;(S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1R,2R)-1-Hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy
99 prices
Selected condition:
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth
  • BroadPharm
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Synthonix
  • TRC
Package
  • 500μg
  • 1mg
  • 0.01g
  • 0.025g
  • 50.00mg
  • 0.05g
  • 001
  • 5mg
  • 10mg
  • 25mg
  • 002
  • 10mM*1mLinDMSO
  • 003
  • 50mg
  • 100mg
  • 0.1g
  • 100.00mg
  • 250mg
  • 500mg
  • 1000mg
  • 10mM(in 1mL DMSO)
  • 25g
  • 10mM(1mLinDMSO)
  • 1g
  • 5g
  • 10g
  • 10mM(in1mLDMSO)
  • Manufactureraablocks
  • Product numberAA003573
  • Product descriptionMonomethyl Auristatin E ≥97%
  • Packaging5mg
  • Price$10
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003573
  • Product descriptionMonomethyl Auristatin E ≥97%
  • Packaging10mg
  • Price$11
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003573
  • Product descriptionMonomethyl Auristatin E 98%
  • Packaging25mg
  • Price$15
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003573
  • Product descriptionMonomethyl Auristatin E 98%
  • Packaging50mg
  • Price$29
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003573
  • Product descriptionMonomethyl Auristatin E 98%
  • Packaging100mg
  • Price$35
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003573
  • Product descriptionMonomethyl Auristatin E 98%
  • Packaging250mg
  • Price$54
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003573
  • Product descriptionMonomethyl Auristatin E 98%
  • Packaging1g
  • Price$149
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003573
  • Product descriptionMonomethyl Auristatin E 98%
  • Packaging5g
  • Price$555
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003573
  • Product descriptionMonomethyl Auristatin E 98%
  • Packaging25g
  • Price$2340
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10353
  • Product descriptionMonomethyl auristatin E 98%
  • Packaging5G
  • Price$830
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10353
  • Product descriptionMonomethyl auristatin E 98%
  • Packaging1G
  • Price$225
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10353
  • Product descriptionMonomethyl auristatin E 98%
  • Packaging25MG
  • Price$30
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10353
  • Product descriptionMonomethyl auristatin E 98%
  • Packaging100MG
  • Price$55
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product numberY1831
  • Product descriptionMonomethylauristatinE
  • Packaging5mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3631
  • Product descriptionMonomethyl auristatin E
  • Packaging10mM(in1mLDMSO)
  • Price$83
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3631
  • Product descriptionMonomethylauristatinE
  • Packaging1mg
  • Price$85
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA003573 Monomethyl Auristatin E ≥97% 5mg $10 2026-05-28 Buy
aablocks AA003573 Monomethyl Auristatin E ≥97% 10mg $11 2026-05-28 Buy
aablocks AA003573 Monomethyl Auristatin E 98% 25mg $15 2026-05-28 Buy
aablocks AA003573 Monomethyl Auristatin E 98% 50mg $29 2026-05-28 Buy
aablocks AA003573 Monomethyl Auristatin E 98% 100mg $35 2026-05-28 Buy
aablocks AA003573 Monomethyl Auristatin E 98% 250mg $54 2026-05-28 Buy
aablocks AA003573 Monomethyl Auristatin E 98% 1g $149 2026-05-28 Buy
aablocks AA003573 Monomethyl Auristatin E 98% 5g $555 2026-05-28 Buy
aablocks AA003573 Monomethyl Auristatin E 98% 25g $2340 2026-05-28 Buy
ACHEMBLOCK 10353 Monomethyl auristatin E 98% 5G $830 2026-05-27 Buy
ACHEMBLOCK 10353 Monomethyl auristatin E 98% 1G $225 2026-05-27 Buy
ACHEMBLOCK 10353 Monomethyl auristatin E 98% 25MG $30 2026-05-27 Buy
ACHEMBLOCK 10353 Monomethyl auristatin E 98% 100MG $55 2026-05-27 Buy
AK Scientific Y1831 MonomethylauristatinE 5mg $49 2021-12-16 Buy
ApexBio Technology A3631 Monomethyl auristatin E 10mM(in1mLDMSO) $83 2026-05-06 Buy
ApexBio Technology A3631 MonomethylauristatinE 1mg $85 2021-12-16 Buy

Properties

Melting point :>90°C (dec.)
Boiling point :873.5±65.0 °C(Predicted)
Density :1.088±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly, Sonicated)
pka :13.66±0.20(Predicted)
form :Solid
color :White to Off-White
InChIKey :RJACXSRFJLSJEZ-UIJRFTGLSA-N
SMILES :C(NC(=O)[C@H](C(C)C)NC)(=O)[C@H](C(C)C)N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1CCC[C@H]1[C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C1=CC=CC=C1)=O)=O)C
CAS DataBase Reference :474645-27-7

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Dolastatin 10 is a natural antimitotic and antineoplastic agent that binds to tubulin and inhibits tubulin polymerization. Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity. MMAE is typically coupled to the antibody via a protease-cleavable linker, allowing separation of the drug from the antibody following intracellular localization.

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