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ChemicalBook >> CAS DataBase List >> Neratinib

Neratinib

Neratinib price.
  • $10 - $5273
  • Product name: Neratinib
  • CAS: 698387-09-6
  • MF: C30H29ClN6O3
  • MW: 557.04
  • EINECS:811-237-1
  • MDL Number:MFCD09752958
  • Synonyms:Neratinib(HKI-272);(2E)-N-[4-[[3-chloro-4-(2-pyridinylMethoxy)phenyl]aMino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(diMethylaMino)-2-butenaMide;neratinib;(E)-N-[4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide;N-(4-(3-Chloro-4-(2-pyridinylmethoxy)anilino)-3-cyano-7-ethoxy-6-quinolyl)-4-(dimethylamino)-2-butenamide;Unii-jjh94R3pwb;(2e)-n-(4-((3-chloro-4-((pyridin-2-yl)Methoxy)phenyl)aMino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(diMethylaMino)but-2-enaMide neratinib;HKI-272 Neratinib
106 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Chemtos
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TCI Chemical
  • TRC
Package
  • 10mM*1mLinDMSO(Solution)
  • 20mg
  • 200mg
  • 250.00mg
  • 500mg
  • 1.00g
  • 1000mg
  • 5.00g
  • 50 mg
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 10mM*1mLinDMSO
  • 100 mg
  • 10mM(in 1mL DMSO)
  • 1MG
  • 1unit
  • 5mg
  • 10MG
  • 25mg
  • 50mg
  • 250mg
  • 10mM(in1mLDMSO)
  • 100mg
  • 5g
  • EvaluationSample
  • 1g
  • Manufactureraablocks
  • Product numberAA0035AU
  • Product description(2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide ≥99%
  • Packaging5mg
  • Price$10
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0035AU
  • Product description(2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide ≥99%
  • Packaging25mg
  • Price$20
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0035AU
  • Product description(2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide 98%
  • Packaging100mg
  • Price$29
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0035AU
  • Product description(2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide 98%
  • Packaging250mg
  • Price$35
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0035AU
  • Product description(2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide 98%
  • Packaging1g
  • Price$76
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0035AU
  • Product description(2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide 98%
  • Packaging5g
  • Price$269
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10409
  • Product descriptionNeratinib 98%
  • Packaging1G
  • Price$155
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10409
  • Product descriptionNeratinib 98%
  • Packaging100MG
  • Price$35
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10409
  • Product descriptionNeratinib 98%
  • Packaging5G
  • Price$530
  • Updated2026-05-27
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-N0326-M250
  • Product descriptionNeratinib ≥98%
  • Packaging250mg
  • Price$316
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-N0326-M100
  • Product descriptionNeratinib ≥98%
  • Packaging100mg
  • Price$141
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-N0326-M050
  • Product descriptionNeratinib ≥98%
  • Packaging50mg
  • Price$105
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-N0326-M100
  • Product descriptionNeratinib ≥98%
  • Packaging100mg
  • Price$158
  • Updated2026-05-06
  • Buy
  • ManufacturerAK Scientific
  • Product numberX2638
  • Product descriptionNeratinib
  • Packaging1g
  • Price$2423
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150970
  • Product description(E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide 98+%
  • Packaging1g
  • Price$93
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0025184
  • Product descriptionNERATINIB 95.00%
  • Packaging1MG
  • Price$203.7
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA0035AU (2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide ≥99% 5mg $10 2026-05-28 Buy
aablocks AA0035AU (2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide ≥99% 25mg $20 2026-05-28 Buy
aablocks AA0035AU (2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide 98% 100mg $29 2026-05-28 Buy
aablocks AA0035AU (2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide 98% 250mg $35 2026-05-28 Buy
aablocks AA0035AU (2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide 98% 1g $76 2026-05-28 Buy
aablocks AA0035AU (2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide 98% 5g $269 2026-05-28 Buy
ACHEMBLOCK 10409 Neratinib 98% 1G $155 2026-05-27 Buy
ACHEMBLOCK 10409 Neratinib 98% 100MG $35 2026-05-27 Buy
ACHEMBLOCK 10409 Neratinib 98% 5G $530 2026-05-27 Buy
Adipogen Life Sciences CDX-N0326-M250 Neratinib ≥98% 250mg $316 2026-05-06 Buy
Adipogen Life Sciences CDX-N0326-M100 Neratinib ≥98% 100mg $141 2021-12-16 Buy
Adipogen Life Sciences CDX-N0326-M050 Neratinib ≥98% 50mg $105 2026-05-06 Buy
Adipogen Life Sciences CDX-N0326-M100 Neratinib ≥98% 100mg $158 2026-05-06 Buy
AK Scientific X2638 Neratinib 1g $2423 2021-12-16 Buy
Ambeed A150970 (E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide 98+% 1g $93 2021-12-16 Buy
American Custom Chemicals Corporation API0025184 NERATINIB 95.00% 1MG $203.7 2021-12-16 Buy

Properties

Melting point :185-187°C
Boiling point :757.0±60.0 °C(Predicted)
Density :1.33
storage temp. :Refrigerator
solubility :Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated)
form :Off-white solid.
pka :12.37±0.43(Predicted)
color :Pale Yellow to Yellow
InChIKey :JWNPDZNEKVCWMY-VQHVLOKHSA-N
SMILES :C(NC1=C(OCC)C=C2C(=C1)C(NC1=CC=C(OCC3=NC=CC=C3)C(Cl)=C1)=C(C#N)C=N2)(=O)/C=C/CN(C)C

Safety Information

Symbol(GHS): Corrosion (GHS05)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H290 May be corrosive to metals Corrosive to Metals Category 1 Warning P234, P390, P404
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
Precautionary statements:
P234 Keep only in original container.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363 Wash contaminated clothing before reuse.
P390 Absorb spillage to prevent material damage.
P405 Store locked up.
P406 Store in corrosive resistant/… container with a resistant inner liner.
P501 Dispose of contents/container to..…

Description

The receptor tyrosine kinase HER2 (ErbB2) is a key component of epidermal growth factor receptor complexes that are known to have central roles in cell proliferation and cancer. Neratinib is an orally active, irreversible inhibitor of the HER2 kinase (IC50 = 59 nM). It also potently inhibits several mutants of HER2 and shows 10-fold or greater selectivity over a wide variety of other kinases. As an irreversible inhibitor, neratinib may circumvent acquired resistance developed against reversible inhibitors, including gefitinib . Neratinib has been evaluated in clinical trials against cancers characterized by HER2 overexpression or HER2 activating mutations.

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