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ChemicalBook >> CAS DataBase List >> Nintedanib

Nintedanib

Nintedanib price.
  • $5 - $1490
  • Product name: Nintedanib
  • CAS: 656247-17-5
  • MF: C31H33N5O4
  • MW: 539.64
  • EINECS:1592732-453-0
  • MDL Number:MFCD11974012
  • Synonyms:Nintedanib/Intedanib/Vargatef;BIBF 1120; VARGATEF; INTEDANIB;INTEDANIB BASE;Intedanib Vargatef;Nintedanib, Free Base, >99%;methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate;NTEDANIB;(3Z)-2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-Indole-6-carboxylic acid methyl ester;methyl (Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate
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  • 10mM*1mLinDMSO
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  • EvaluationSample
  • 100g
  • 10mM(in1mLDMSO)
  • 10mM(in 1mL DMSO)
  • Manufactureraablocks
  • Product numberAA00FBWQ
  • Product descriptionMethyl (Z)-3-[[[4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl]amino](phenyl)methylene]-2-oxoindoline-6-carboxylate 98%
  • Packaging50mg
  • Price$5
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00FBWQ
  • Product descriptionMethyl (Z)-3-[[[4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl]amino](phenyl)methylene]-2-oxoindoline-6-carboxylate 98%
  • Packaging100mg
  • Price$7
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00FBWQ
  • Product descriptionMethyl (Z)-3-[[[4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl]amino](phenyl)methylene]-2-oxoindoline-6-carboxylate 98%
  • Packaging250mg
  • Price$11
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00FBWQ
  • Product descriptionMethyl (Z)-3-[[[4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl]amino](phenyl)methylene]-2-oxoindoline-6-carboxylate 98%
  • Packaging1g
  • Price$24
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00FBWQ
  • Product descriptionMethyl (Z)-3-[[[4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl]amino](phenyl)methylene]-2-oxoindoline-6-carboxylate 98%
  • Packaging5g
  • Price$77
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00FBWQ
  • Product descriptionMethyl (Z)-3-[[[4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl]amino](phenyl)methylene]-2-oxoindoline-6-carboxylate 98%
  • Packaging10g
  • Price$135
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00FBWQ
  • Product descriptionMethyl (Z)-3-[[[4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl]amino](phenyl)methylene]-2-oxoindoline-6-carboxylate 98%
  • Packaging25g
  • Price$315
  • Updated2026-05-28
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  • ManufacturerAccelPharmtech
  • Product numberYL1327
  • Product descriptionNintedanib 98%+
  • Packaging10G
  • Price$430
  • Updated2021-12-16
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  • ManufacturerAccelPharmtech
  • Product numberYL1327
  • Product descriptionNintedanib 98%+
  • Packaging10G
  • Price$430
  • Updated2026-05-21
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  • ManufacturerAccelPharmtech
  • Product numberYL1327
  • Product descriptionNintedanib 98%+
  • Packaging25G
  • Price$780
  • Updated2021-12-16
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  • ManufacturerAccelPharmtech
  • Product numberYL1327
  • Product descriptionNintedanib 98%+
  • Packaging25G
  • Price$780
  • Updated2026-05-21
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  • ManufacturerAccelPharmtech
  • Product numberYL1327
  • Product descriptionNintedanib 98%+
  • Packaging50G
  • Price$1490
  • Updated2021-12-16
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  • ManufacturerAccelPharmtech
  • Product numberYL1327
  • Product descriptionNintedanib 98%+
  • Packaging50G
  • Price$1490
  • Updated2026-05-21
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  • ManufacturerACHEMBLOCK
  • Product numberI-9753
  • Product descriptionBIBF-1120 98%
  • Packaging25G
  • Price$330
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberI-9753
  • Product descriptionBIBF-1120 98%
  • Packaging5G
  • Price$110
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberI-9753
  • Product descriptionBIBF-1120 98%
  • Packaging1G
  • Price$35
  • Updated2026-05-27
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Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00FBWQ Methyl (Z)-3-[[[4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl]amino](phenyl)methylene]-2-oxoindoline-6-carboxylate 98% 50mg $5 2026-05-28 Buy
aablocks AA00FBWQ Methyl (Z)-3-[[[4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl]amino](phenyl)methylene]-2-oxoindoline-6-carboxylate 98% 100mg $7 2026-05-28 Buy
aablocks AA00FBWQ Methyl (Z)-3-[[[4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl]amino](phenyl)methylene]-2-oxoindoline-6-carboxylate 98% 250mg $11 2026-05-28 Buy
aablocks AA00FBWQ Methyl (Z)-3-[[[4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl]amino](phenyl)methylene]-2-oxoindoline-6-carboxylate 98% 1g $24 2026-05-28 Buy
aablocks AA00FBWQ Methyl (Z)-3-[[[4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl]amino](phenyl)methylene]-2-oxoindoline-6-carboxylate 98% 5g $77 2026-05-28 Buy
aablocks AA00FBWQ Methyl (Z)-3-[[[4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl]amino](phenyl)methylene]-2-oxoindoline-6-carboxylate 98% 10g $135 2026-05-28 Buy
aablocks AA00FBWQ Methyl (Z)-3-[[[4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl]amino](phenyl)methylene]-2-oxoindoline-6-carboxylate 98% 25g $315 2026-05-28 Buy
AccelPharmtech YL1327 Nintedanib 98%+ 10G $430 2021-12-16 Buy
AccelPharmtech YL1327 Nintedanib 98%+ 10G $430 2026-05-21 Buy
AccelPharmtech YL1327 Nintedanib 98%+ 25G $780 2021-12-16 Buy
AccelPharmtech YL1327 Nintedanib 98%+ 25G $780 2026-05-21 Buy
AccelPharmtech YL1327 Nintedanib 98%+ 50G $1490 2021-12-16 Buy
AccelPharmtech YL1327 Nintedanib 98%+ 50G $1490 2026-05-21 Buy
ACHEMBLOCK I-9753 BIBF-1120 98% 25G $330 2026-05-27 Buy
ACHEMBLOCK I-9753 BIBF-1120 98% 5G $110 2026-05-27 Buy
ACHEMBLOCK I-9753 BIBF-1120 98% 1G $35 2026-05-27 Buy

Properties

Melting point :>237oC (dec.)
Boiling point :742.2±60.0 °C(Predicted)
Density :1.284±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Yellow solid.
pka :11.06±0.20(Predicted)
color :Light Yellow to Light Green
InChIKey :XZXHXSATPCNXJR-ZIADKAODSA-N
SMILES :C(/C1C=CC=CC=1)(=C1\C(NC2=CC(C(=O)OC)=CC=C\12)=O)\NC1C=CC(N(C)C(=O)CN2CCN(C)CC2)=CC=1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Nintedanib is an oral administrated triple tyrosine kinase inhibitors developed by Boehringer Ingelheim, Germany. Its targets include platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and basic fiber (BFGF), being able to also inhibit the activation of MAPK and Akt. At present, it is mainly used for cancer treatment, such as colorectal cancer, ovarian cancer and multiple myeloma. The study regarding to the respiratory diseases mainly focuses on the clinical treatment of advanced non-small cell lung cancer (NSCLC) and idiopathic pulmonary fibrosis (IPF). In June 2014, Boehringer Ingelheim has announced that the marketing authorization application of Nintedanib for the treatment of Idiopathic Pulmonary Fibrosis (IPF) had been confirmed by the European Medicines Agency (EMA) and been included in the accelerated approval list by the EMA.

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