ONX-0914
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- $30 - $2700
- Product name: ONX-0914
- CAS: 960374-59-8
- MF: C31H40N4O7
- MW: 580.67
- EINECS:
- MDL Number:MFCD26794217
- Synonyms:ONX 0914;PR 957;PR 957(ONX 0914);N-[2-(4-Morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-tyrosinamide;L-Tyrosinamide, N-[2-(4-morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-;N-[2-(4-Morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-tyrosinamide ONX0914(PR-957);(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide;ONX-0914, >=99%
72 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 2x5mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 2mg
- 10mM(in1mLDMSO)
- 250mg
- 1g
- 2g
- 10mM*1mLinDMSO(Solution)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- EvaluationSample
- Manufactureraablocks
- Product numberAA00IJOO
- Product description(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide
- Packaging1mg
- Price$59
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00IJOO
- Product description(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide ≥98%
- Packaging5mg
- Price$66
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00IJOO
- Product description(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide 99%
- Packaging10mg
- Price$103
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00IJOO
- Product description(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide 99%
- Packaging25mg
- Price$206
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00IJOO
- Product description(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide 99%
- Packaging50mg
- Price$347
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00IJOO
- Product description(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide ≥98%
- Packaging100mg
- Price$677
- Updated2026-05-29
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15339
- Product descriptionONX-0914 98%
- Packaging100MG
- Price$715
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15339
- Product descriptionONX-0914 98%
- Packaging25MG
- Price$250
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3674-M005
- Product descriptionONX 0914 ≥98%
- Packaging5mg
- Price$160
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3674-M001
- Product descriptionONX 0914 ≥98%
- Packaging1mg
- Price$60
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3674-M025
- Product descriptionONX0914 ≥98%
- Packaging25mg
- Price$420
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY1243
- Product descriptionONX-0914
- Packaging5mg
- Price$282
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY1243
- Product descriptionONX-0914
- Packaging25mg
- Price$679
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4011
- Product descriptionONX-0914 (PR-957)
- Packaging200mg
- Price$1148
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4011
- Product descriptionONX-0914 (PR-957)
- Packaging100mg
- Price$650
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4011
- Product descriptionONX-0914 (PR-957)
- Packaging50mg
- Price$412
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00IJOO | (2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide | 1mg | $59 | 2026-05-29 | Buy |
| aablocks | AA00IJOO | (2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide ≥98% | 5mg | $66 | 2026-05-29 | Buy |
| aablocks | AA00IJOO | (2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide 99% | 10mg | $103 | 2026-05-29 | Buy |
| aablocks | AA00IJOO | (2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide 99% | 25mg | $206 | 2026-05-29 | Buy |
| aablocks | AA00IJOO | (2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide 99% | 50mg | $347 | 2026-05-29 | Buy |
| aablocks | AA00IJOO | (2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide ≥98% | 100mg | $677 | 2026-05-29 | Buy |
| ACHEMBLOCK | M15339 | ONX-0914 98% | 100MG | $715 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15339 | ONX-0914 98% | 25MG | $250 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-3674-M005 | ONX 0914 ≥98% | 5mg | $160 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3674-M001 | ONX 0914 ≥98% | 1mg | $60 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3674-M025 | ONX0914 ≥98% | 25mg | $420 | 2021-12-16 | Buy |
| AK Scientific | Y1243 | ONX-0914 | 5mg | $282 | 2021-12-16 | Buy |
| AK Scientific | Y1243 | ONX-0914 | 25mg | $679 | 2021-12-16 | Buy |
| ApexBio Technology | A4011 | ONX-0914 (PR-957) | 200mg | $1148 | 2026-05-06 | Buy |
| ApexBio Technology | A4011 | ONX-0914 (PR-957) | 100mg | $650 | 2026-05-06 | Buy |
| ApexBio Technology | A4011 | ONX-0914 (PR-957) | 50mg | $412 | 2026-05-06 | Buy |
Properties
Melting point :>70oC (dec.)
Boiling point :877.953±65.00 °C(Press: 760.00 Torr)(predicted)
Density :1.232±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :12.982±0.46(predicted)
color :White to Pale Yellow
Boiling point :877.953±65.00 °C(Press: 760.00 Torr)(predicted)
Density :1.232±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :12.982±0.46(predicted)
color :White to Pale Yellow
Safety Information
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Description
The immunoproteasome is a specialized, inducible proteasome that generates peptides presented on major histocompatibility complex (MHC) class I molecules to cytotoxic T cells. Stimulation of cells with inflammatory cytokines such as IFN-γ leads to the replacement of constitutive catalytic proteasome β subunits with inducible β subunits (β1i (LMP2), β2i (MECL1), and β5i (LMP7)), which are required for the production of certain MHC class I-restricted T cell epitopes. ONX 0914 is a selective inhibitor of the β5i (LMP7) subunit of the immunoproteasome (IC50s = 65 and 73 nM for mouse and human, respectively) and demonstrates significantly weaker activity at the β5 subunit of the constitutive proteasome (IC50s = 0.92 and 1.04 μM for mouse and human, respectively). It can block the production of IL-23 by activated monocytes and the production of IFN-γ and IL-2 by T cells. ONX 0914 can also inhibit IL-17-producing T cells under TH17-polarizing conditions in vitro and reduce TH1 and TH17 cell differentiation in vivo. This compound has been shown to attenuate disease progression in several experimental models of autoimmune disorders as well as in some hematologic malignancies.More related product prices
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Suppliers and manufacturers
Henan Aochuang Chemical Co.,Ltd.
Changzhou PBpharmaceutical R&D Co.,Ltd
Career Henan Chemica Co
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
Changzhou AniKare Pharmatech Co., Ltd.
ONX-0914
CAS:960374-59-8