PFI-4
|
- $22 - $2809
- Product name: PFI-4
- CAS: 900305-37-5
- MF: C21H24N4O3
- MW: 380.44
- EINECS:
- MDL Number:MFCD14744412
- Synonyms:PFI-4;
N-(1,3-Dimethyl-2-oxo-6-(pyrrolidin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-5 -yl)-2-methoxybenzamide;Benzamide, N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy-;N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide;PFI4;PFI 4;CS-2035;N-(1,3-Dimethyl-2-oxo-6-pyrrolidin-1-yl-2,3-dihydro-1H-benzimidazol-5-yl)-2-methoxybenzamide;N-(1,3-dimethyl-2-oxo-6-pyrrolidin-1-ylbenzimidazol-5-yl)-2-methoxybenzamide
53 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Biosynth
- BroadPharm
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
Package
- 5mg
- 10mg
- 10mM(in1mLDMSO)
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- 10
- 1mg
- 10mM*1mLinDMSO
- 50
- 25mg
- 50mg
- 100mg
- 250MG
- 1g
- 5g
- Manufactureraablocks
- Product numberAA00GU6J
- Product descriptionPFI-4 98%
- Packaging25mg
- Price$79
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GU6J
- Product descriptionPFI-4 98%
- Packaging50mg
- Price$95
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GU6J
- Product descriptionPFI-4 98%
- Packaging100mg
- Price$114
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GU6J
- Product descriptionPFI-4 98%
- Packaging1g
- Price$940
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GU6J
- Product descriptionPFI-4 98%
- Packaging5g
- Price$2809
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GU6J
- Product descriptionPFI-4 98%
- Packaging10mg
- Price$43
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GU6J
- Product descriptionPFI-4 98%
- Packaging5mg
- Price$27
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GU6J
- Product descriptionPFI-4 98%
- Packaging1mg
- Price$22
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY226999
- Product descriptionPFI-4 97.00%
- Packaging250MG
- Price$580
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY226999
- Product descriptionPFI-4 97.00%
- Packaging100MG
- Price$290
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-3047-M005
- Product descriptionPFI-4 ≥95%
- Packaging5mg
- Price$76
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-3047-M001
- Product descriptionPFI-4 ≥95%
- Packaging1mg
- Price$54
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-3047-M010
- Product descriptionPFI-4 ≥95%
- Packaging10mg
- Price$97
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-3047-M050
- Product descriptionPFI-4 ≥95%
- Packaging50mg
- Price$346
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-3047-M100
- Product descriptionPFI-4 ≥95%
- Packaging100mg
- Price$637
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number9021DD
- Product descriptionCID40642506
- Packaging50mg
- Price$220
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00GU6J | PFI-4 98% | 25mg | $79 | 2026-05-28 | Buy |
| aablocks | AA00GU6J | PFI-4 98% | 50mg | $95 | 2026-05-28 | Buy |
| aablocks | AA00GU6J | PFI-4 98% | 100mg | $114 | 2026-05-28 | Buy |
| aablocks | AA00GU6J | PFI-4 98% | 1g | $940 | 2026-05-28 | Buy |
| aablocks | AA00GU6J | PFI-4 98% | 5g | $2809 | 2026-05-28 | Buy |
| aablocks | AA00GU6J | PFI-4 98% | 10mg | $43 | 2026-05-28 | Buy |
| aablocks | AA00GU6J | PFI-4 98% | 5mg | $27 | 2026-05-28 | Buy |
| aablocks | AA00GU6J | PFI-4 98% | 1mg | $22 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y226999 | PFI-4 97.00% | 250MG | $580 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y226999 | PFI-4 97.00% | 100MG | $290 | 2026-05-27 | Buy |
| Adipogen Life Sciences | SYN-3047-M005 | PFI-4 ≥95% | 5mg | $76 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-3047-M001 | PFI-4 ≥95% | 1mg | $54 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-3047-M010 | PFI-4 ≥95% | 10mg | $97 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-3047-M050 | PFI-4 ≥95% | 50mg | $346 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-3047-M100 | PFI-4 ≥95% | 100mg | $637 | 2026-05-06 | Buy |
| AK Scientific | 9021DD | CID40642506 | 50mg | $220 | 2021-12-16 | Buy |
Properties
Boiling point :512.1±50.0 °C(Predicted)
Density :1.291±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :insoluble in H2O; ≥13.3 mg/mL in DMSO; ≥2.87 mg/mL in EtOH with gentle warming and ultrasonic
pka :12.88±0.20(Predicted)
form :powder
color :white to beige
InChI :1S/C21H24N4O3/c1-23-17-12-15(22-20(26)14-8-4-5-9-19(14)28-3)16(25-10-6-7-11-25)13-18(17)24(2)21(23)27/h4-5,8-9,12-13H,6-7,10-11H2,1-3H3,(H,22,26)
InChIKey :QCIJLRJBZDBVDB-UHFFFAOYSA-N
SMILES :CN(C1=CC(NC(C2=C(OC)C=CC=C2)=O)=C(N3CCCC3)C=C1N4C)C4=O
Density :1.291±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :insoluble in H2O; ≥13.3 mg/mL in DMSO; ≥2.87 mg/mL in EtOH with gentle warming and ultrasonic
pka :12.88±0.20(Predicted)
form :powder
color :white to beige
InChI :1S/C21H24N4O3/c1-23-17-12-15(22-20(26)14-8-4-5-9-19(14)28-3)16(25-10-6-7-11-25)13-18(17)24(2)21(23)27/h4-5,8-9,12-13H,6-7,10-11H2,1-3H3,(H,22,26)
InChIKey :QCIJLRJBZDBVDB-UHFFFAOYSA-N
SMILES :CN(C1=CC(NC(C2=C(OC)C=CC=C2)=O)=C(N3CCCC3)C=C1N4C)C4=O
Safety Information
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Description
The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1, aka BR140 or Peregrin, is important for maintaining Hox gene expression and the development of multiple tissues, axial skeleton, and the hematopoietic system. PFI-4 is a chemical probe that specifically binds to the bromodomain of BRPF1 (Kd = 13 nM), inhibiting binding to tri-acetylated histone 4 (residues 1-21). It has much lower affinity for bromodomain 1 of BRD4 (Kd = >50 μM) and is selective for BRPF1 over BRPF2 and BRPF3. PFI-4 is potent in cells, with an IC50 value of 250 nM. See the Structural Genomics Consortium (SGC) website for more information.Related product price
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