PIPERLONGUMINE
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- $9 - $1963.5
- Product name: PIPERLONGUMINE
- CAS: 20069-09-4
- MF: C17H19NO5
- MW: 317.34
- EINECS:246-914-5
- MDL Number:MFCD00075706
- Synonyms:PIPERLONGUMIN;PIPERLONGUMINE;5,6-DIHYDRO-1-[1-OXO-3-3,4,5-TRIMETHOXYPHENYL-TRANS-2-PROPENYL]-21H-PYRIDINONE;piperlongumine from long pepper;(E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one;PPLGM;1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one;-1-(3-(3,4,5-Trimethoxyphenyl)
147 prices
Selected condition：
Brand
- A1 Biochem Labs
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- BroadPharm
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 20mg
- 25mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 50
- 0.5g
- 10
- 10mM(1mLinDMSO)
- 10mM(in1mLDMSO)
- 1g
- 1000mg
- 2g
- 5g
- 50.00g
- 250.00g
- 10mM(in 1mL DMSO)
- 100.00g
- ManufacturerA1 Biochem Labs
- Product number6563789
- Product descriptionPiperlongumine 96%
- Packaging500mg
- Price$275
- Updated2021-12-16
- Buy
- ManufacturerA1 Biochem Labs
- Product number6563789
- Product descriptionPiperlongumine 96%
- Packaging1g
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerA1 Biochem Labs
- Product numberA1-00162
- Product descriptionPiperlongumine 0.96
- Packaging1g
- Price$300
- Updated2026-06-05
- Buy
- Manufactureraablocks
- Product numberAA002CU6
- Product descriptionPiperlongumine 98%
- Packaging5g
- Price$672
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002CU6
- Product descriptionPiperlongumine 98%
- Packaging500mg
- Price$165
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002CU6
- Product descriptionPiperlongumine 98%
- Packaging1g
- Price$224
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002CU6
- Product descriptionPiperlongumine 98%
- Packaging250mg
- Price$88
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002CU6
- Product descriptionPiperlongumine 98%
- Packaging5mg
- Price$18
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002CU6
- Product descriptionPiperlongumine 98%
- Packaging10mg
- Price$23
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002CU6
- Product descriptionPiperlongumine 98%
- Packaging1mg
- Price$9
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002CU6
- Product descriptionPiperlongumine 98%
- Packaging25mg
- Price$33
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002CU6
- Product descriptionPiperlongumine 98%
- Packaging100mg
- Price$48
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberO32844
- Product descriptionPiperlongumine 98%
- Packaging1G
- Price$375
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO32844
- Product descriptionPiperlongumine 98%
- Packaging5G
- Price$1250
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0024-M050
- Product descriptionPiperlongumine ≥97%
- Packaging50mg
- Price$90
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberCDX-P0921-M250
- Product descriptionPiperlongumine (natural) ≥98%(HPLC)
- Packaging250mg
- Price$350
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| A1 Biochem Labs | 6563789 | Piperlongumine 96% | 500mg | $275 | 2021-12-16 | Buy |
| A1 Biochem Labs | 6563789 | Piperlongumine 96% | 1g | $400 | 2021-12-16 | Buy |
| A1 Biochem Labs | A1-00162 | Piperlongumine 0.96 | 1g | $300 | 2026-06-05 | Buy |
| aablocks | AA002CU6 | Piperlongumine 98% | 5g | $672 | 2026-05-28 | Buy |
| aablocks | AA002CU6 | Piperlongumine 98% | 500mg | $165 | 2026-05-28 | Buy |
| aablocks | AA002CU6 | Piperlongumine 98% | 1g | $224 | 2026-05-28 | Buy |
| aablocks | AA002CU6 | Piperlongumine 98% | 250mg | $88 | 2026-05-28 | Buy |
| aablocks | AA002CU6 | Piperlongumine 98% | 5mg | $18 | 2026-05-28 | Buy |
| aablocks | AA002CU6 | Piperlongumine 98% | 10mg | $23 | 2026-05-28 | Buy |
| aablocks | AA002CU6 | Piperlongumine 98% | 1mg | $9 | 2026-05-28 | Buy |
| aablocks | AA002CU6 | Piperlongumine 98% | 25mg | $33 | 2026-05-28 | Buy |
| aablocks | AA002CU6 | Piperlongumine 98% | 100mg | $48 | 2026-05-28 | Buy |
| ACHEMBLOCK | O32844 | Piperlongumine 98% | 1G | $375 | 2026-05-27 | Buy |
| ACHEMBLOCK | O32844 | Piperlongumine 98% | 5G | $1250 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CN2-0024-M050 | Piperlongumine ≥97% | 50mg | $90 | 2026-05-06 | Buy |
| Adipogen Life Sciences | CDX-P0921-M250 | Piperlongumine (natural) ≥98%(HPLC) | 250mg | $350 | 2026-05-06 | Buy |
Properties
Melting point :124°C
Boiling point :475.6±45.0 °C(Predicted)
Density :1.223±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥5mg/mL at warmed to 60°C
pka :-1.88±0.20(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Cosmetics Ingredients Functions :SKIN CONDITIONING - MISCELLANEOUS
ANTIOXIDANT
BLEACHING InChI :InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+
InChIKey :VABYUUZNAVQNPG-BQYQJAHWSA-N
SMILES :C1(=O)N(C(=O)/C=C/C2=CC(OC)=C(OC)C(OC)=C2)CCC=C1
LogP :2.340 (est)
Boiling point :475.6±45.0 °C(Predicted)
Density :1.223±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥5mg/mL at warmed to 60°C
pka :-1.88±0.20(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Cosmetics Ingredients Functions :SKIN CONDITIONING - MISCELLANEOUS
ANTIOXIDANT
BLEACHING InChI :InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+
InChIKey :VABYUUZNAVQNPG-BQYQJAHWSA-N
SMILES :C1(=O)N(C(=O)/C=C/C2=CC(OC)=C(OC)C(OC)=C2)CCC=C1
LogP :2.340 (est)
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species (ROS) generated by their metastatic transformation. Piperlongumine, isolated from the Piper longum L. plant, is a small molecule that selectively increases the level of reactive oxygen species (ROS) and apoptosis in cancer cells but not in normal cells. At concentrations less than 15 μM, piperlongumine induces cell death, upregulating proapoptotic genes, and repressing pro-survival genes. In established bladder, breast, lung, and melanoma tumor xenografts in mice, piperlongumine administered daily at 2.4 mg/kg for 2 weeks inhibits tumor growth and angiogenesis. Piperlongumine increases ROS in both cancer cells and normal cells engineered to have a cancer geneotype by selectively binding to proteins known to regulate redox and ROS homeostasis. Previously, piperlongumine has been used as a crude treatment to improve poor blood circulation. It affects platelet function in rabbits by inhibiting platelet aggregation induced by the thromboxane A2 agonist U-46619 with a Ki value of 6.8 μM.More related product prices
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PIPERLONGUMINE
$9-1963.5
Suppliers and manufacturers
Hydebio Labs Co.,Limited
Henan Tianfu Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Shanghai Zheyan Biotech Co., Ltd.
Chengdu Greenpure Biopharma CO.,Ltd
Chengdu GLP biotechnology Co Ltd
Biochempartner
