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ChemicalBook >> CAS DataBase List >> THIOSTREPTON

THIOSTREPTON

$6 - $1238
Product name: THIOSTREPTON
CAS: 1393-48-2
MF: C72H85N19O18S5
MW: 1664.89
EINECS:215-734-9
MDL Number:MFCD00135828
Synonyms:Thiostrepton (200 mg);BryaMycin, Thiactin, AlaninaMide, X 146, A 8506, 6761-31;Thiostrepton, froM StreptoMyces sp.;x146 ;THIOSTREPTON;Alaninamide, L-threonyl-(4S)-2-(1Z)-1-amino-1-propenyl-4,5-dihydro-4-thiazolecarbonyl-2-(1S,2S,3R)-1-amino-2,3-dihydroxy-2-methylbutyl-4-thiazolecarbonyl-2-(5R,6S)-6-2-(1S,2R)-1-amino-2-hydroxypropyl-4-thiazolyl-5-N-(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy;THIOSTREPTION;thiostrepton from streptomyces azureus

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aablocks
ACHEMBLOCK
Ambeed
American Custom Chemicals Corporation
ApexBio Technology
Apolloscientific
AvaChem
Biorbyt Ltd
Cayman Chemical
ChemScene
Crysdot
Matrix Scientific
Sigma-Aldrich
Thermo Scientific Chemicals
Tocris
TRC
Usbiological

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1g
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Manufactureraablocks
Product numberAA006XK6
Product descriptionThiostrepton 98%
Packaging1mg
Price$9
Updated2026-05-28
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Manufactureraablocks
Product numberAA006XK6
Product descriptionThiostrepton 98%
Packaging10mg
Price$12
Updated2026-05-28
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Manufactureraablocks
Product numberAA006XK6
Product descriptionThiostrepton 98%
Packaging50mg
Price$27
Updated2026-05-28
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Manufactureraablocks
Product numberAA006XK6
Product descriptionThiostrepton 98%
Packaging100mg
Price$41
Updated2026-05-28
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Manufactureraablocks
Product numberAA006XK6
Product descriptionThiostrepton 98%
Packaging250mg
Price$68
Updated2026-05-28
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Manufactureraablocks
Product numberAA006XK6
Product descriptionThiostrepton ≥95%
Packaging500mg
Price$76
Updated2026-05-28
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Manufactureraablocks
Product numberAA006XK6
Product descriptionThiostrepton ≥95%
Packaging1g
Price$115
Updated2026-05-28
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Manufactureraablocks
Product numberAA006XK6
Product descriptionThiostrepton ≥95%
Packaging5g
Price$494
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberZ238342
Product descriptionThiostrepton 98%
Packaging1G
Price$265
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberZ238342
Product descriptionThiostrepton 98%
Packaging250MG
Price$110
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberZ238342
Product descriptionThiostrepton 98%
Packaging5G
Price$925
Updated2026-05-27
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ManufacturerAmbeed
Product numberA265605
Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
Packaging1mg
Price$6
Updated2021-12-16
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ManufacturerAmbeed
Product numberA265605
Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
Packaging250mg
Price$70
Updated2021-12-16
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ManufacturerAmbeed
Product numberA265605
Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
Packaging50mg
Price$32
Updated2021-12-16
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ManufacturerAmbeed
Product numberA265605
Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
Packaging10mg
Price$14
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0004400
Product descriptionThiostrepton 95.00%
Packaging1G
Price$693.92
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA006XK6	Thiostrepton 98%	1mg	$9	2026-05-28	Buy
aablocks	AA006XK6	Thiostrepton 98%	10mg	$12	2026-05-28	Buy
aablocks	AA006XK6	Thiostrepton 98%	50mg	$27	2026-05-28	Buy
aablocks	AA006XK6	Thiostrepton 98%	100mg	$41	2026-05-28	Buy
aablocks	AA006XK6	Thiostrepton 98%	250mg	$68	2026-05-28	Buy
aablocks	AA006XK6	Thiostrepton ≥95%	500mg	$76	2026-05-28	Buy
aablocks	AA006XK6	Thiostrepton ≥95%	1g	$115	2026-05-28	Buy
aablocks	AA006XK6	Thiostrepton ≥95%	5g	$494	2026-05-28	Buy
ACHEMBLOCK	Z238342	Thiostrepton 98%	1G	$265	2026-05-27	Buy
ACHEMBLOCK	Z238342	Thiostrepton 98%	250MG	$110	2026-05-27	Buy
ACHEMBLOCK	Z238342	Thiostrepton 98%	5G	$925	2026-05-27	Buy
Ambeed	A265605	N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%	1mg	$6	2021-12-16	Buy
Ambeed	A265605	N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%	250mg	$70	2021-12-16	Buy
Ambeed	A265605	N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%	50mg	$32	2021-12-16	Buy
Ambeed	A265605	N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%	10mg	$14	2021-12-16	Buy
American Custom Chemicals Corporation	API0004400	Thiostrepton 95.00%	1G	$693.92	2021-12-16	Buy

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Properties

Melting point :248-257°C (dec.)
alpha :D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine)
Density :1.0824 (rough estimate)
refractive index :1.6700 (estimate)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO or chloroform
form :Off-white powder
pka :10.43±0.46(Predicted)
color :Off-white
Water Solubility :0.24g/L(28 ºC)
Merck :13,9440
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
InChIKey :NSFFHOGKXHRQEW-MRQRIGNGNA-N

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.

Description

The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Thiostrepton is a natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself. Through this mechanism, thiostrepton prevents proliferation and induces apoptosis in human cancer cells. These effects correlate with the ability of thiostrepton to act as a proteasome inhibitor.

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THIOSTREPTON

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