XE 991 dihydrochloride
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- $29 - $3780
- Product name: XE 991 dihydrochloride
- CAS: 122955-13-9
- MF: C26H21ClN2O
- MW: 412.92
- EINECS:
- MDL Number:MFCD09055426
- Synonyms:XE 991 (hydrochloride);10,10-bis(pyridin-4-ylmethyl)anthracen-9-one:dihydrochloride;10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;XE991 HCl (LS190926);XE991,inhibit,XE 991 dihydrochloride,KcsA,XE 991,XE-991,Inhibitor,Potassium Channel;XE 991 HCl;10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride;blocks M current
49 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Ambeed
- American Custom Chemicals Corporation
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1G
- Manufactureraablocks
- Product numberAA01E0BE
- Product description10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride ≥99%
- Packaging1mg
- Price$29
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0BE
- Product description10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride ≥98%
- Packaging5mg
- Price$69
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0BE
- Product description10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride ≥99%
- Packaging10mg
- Price$126
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0BE
- Product description10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride ≥99%
- Packaging25mg
- Price$204
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0BE
- Product description10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride ≥99%
- Packaging50mg
- Price$299
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0BE
- Product description10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride ≥99%
- Packaging100mg
- Price$467
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0BE
- Product description10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride ≥99%
- Packaging250mg
- Price$746
- Updated2026-05-30
- Buy
- ManufacturerACHEMBLOCK
- Product numberX203356
- Product descriptionXE 991 dihydrochloride 98.00%
- Packaging250MG
- Price$1260
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberX203356
- Product descriptionXE 991 dihydrochloride 98.00%
- Packaging250MG
- Price$1260
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX203356
- Product descriptionXE 991 dihydrochloride 98.00%
- Packaging1G
- Price$3780
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberX203356
- Product descriptionXE 991 dihydrochloride 98.00%
- Packaging1G
- Price$3780
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX203356
- Product descriptionXE 991 dihydrochloride 98.00%
- Packaging100MG
- Price$700
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX203356
- Product descriptionXE 991 dihydrochloride 98.00%
- Packaging100MG
- Price$700
- Updated2026-05-25
- Buy
- ManufacturerAmbeed
- Product numberA268758
- Product descriptionXE991Dihydrochloride 98+%
- Packaging10mg
- Price$84
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA268758
- Product descriptionXE991Dihydrochloride 98+%
- Packaging5mg
- Price$64
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA268758
- Product descriptionXE991Dihydrochloride 98+%
- Packaging1g
- Price$728
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01E0BE | 10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride ≥99% | 1mg | $29 | 2026-05-30 | Buy |
| aablocks | AA01E0BE | 10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride ≥98% | 5mg | $69 | 2026-05-30 | Buy |
| aablocks | AA01E0BE | 10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride ≥99% | 10mg | $126 | 2026-05-30 | Buy |
| aablocks | AA01E0BE | 10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride ≥99% | 25mg | $204 | 2026-05-30 | Buy |
| aablocks | AA01E0BE | 10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride ≥99% | 50mg | $299 | 2026-05-30 | Buy |
| aablocks | AA01E0BE | 10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride ≥99% | 100mg | $467 | 2026-05-30 | Buy |
| aablocks | AA01E0BE | 10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride ≥99% | 250mg | $746 | 2026-05-30 | Buy |
| ACHEMBLOCK | X203356 | XE 991 dihydrochloride 98.00% | 250MG | $1260 | 2026-05-25 | Buy |
| ACHEMBLOCK | X203356 | XE 991 dihydrochloride 98.00% | 250MG | $1260 | 2026-05-27 | Buy |
| ACHEMBLOCK | X203356 | XE 991 dihydrochloride 98.00% | 1G | $3780 | 2026-05-25 | Buy |
| ACHEMBLOCK | X203356 | XE 991 dihydrochloride 98.00% | 1G | $3780 | 2026-05-27 | Buy |
| ACHEMBLOCK | X203356 | XE 991 dihydrochloride 98.00% | 100MG | $700 | 2026-05-27 | Buy |
| ACHEMBLOCK | X203356 | XE 991 dihydrochloride 98.00% | 100MG | $700 | 2026-05-25 | Buy |
| Ambeed | A268758 | XE991Dihydrochloride 98+% | 10mg | $84 | 2021-12-16 | Buy |
| Ambeed | A268758 | XE991Dihydrochloride 98+% | 5mg | $64 | 2021-12-16 | Buy |
| Ambeed | A268758 | XE991Dihydrochloride 98+% | 1g | $728 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 2 mg/mL
form :Powder
color :Off-white to light yellow
Water Solubility :Soluble to 100 mM in water
solubility :DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 2 mg/mL
form :Powder
color :Off-white to light yellow
Water Solubility :Soluble to 100 mM in water
Safety Information
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Description
The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 μM, respectively) as well as KCNQ2+3 heteromultimers (IC50 = 0.6 μM). It much less effectively blocks eag, erg, and elk channels. The effectiveness of XE 991 against KCNQ channels depends on partners or accessory proteins. Through these actions, XE 991 enhances acetylcholine release from rat brain slices (EC50 = 490 nM) and shows good in vivo potency and duration of action, suggesting utility in Alzheimer’s disease therapeutics. While early studies focused on actions in the central nervous system, XE 991 can be used to explore the roles of KCNQ channels in neuronal regulation throughout the body.More related product prices
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