nemorosone
|
- $44 - $383
- Product name: nemorosone
- CAS: 351416-47-2
- MF: C33H42O4
- MW: 502.69
- EINECS:
- MDL Number:MFCD31579645
- Synonyms:nemorosone;Bicyclo[3.3.1]non-3-ene-2,9-dione, 1-benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris(3-methyl-2-butenyl)-, (1R,5R,7S)- (9CI);(1R,5S,7S)-rel-5-benzoyl-4-hydroxy-6,6-dimethyl-1,3,7-tris(3-methyl-2-buten-1-yl)-bicyclo[3.3.1]non-3-ene-2,9-dione
13 prices
Selected condition：
Brand
- aablocks
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- ChemScene
Package
- 1mg
- 5mg
- 10mg
- Manufactureraablocks
- Product numberAA01EQ4G
- Product descriptionNemorosone ≥98%
- Packaging1mg
- Price$49
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EQ4G
- Product descriptionNemorosone ≥98%
- Packaging10mg
- Price$283
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EQ4G
- Product descriptionNemorosone ≥98%
- Packaging5mg
- Price$167
- Updated2026-05-30
- Buy
- ManufacturerAK Scientific
- Product number8631CC
- Product descriptionNemorosone
- Packaging10mg
- Price$383
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberBA3301
- Product descriptionNemorosone
- Packaging1mg
- Price$83
- Updated2026-05-06
- Buy
- ManufacturerCayman Chemical
- Product number24256
- Product descriptionNemorosone ≥98%
- Packaging5mg
- Price$167
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number24256
- Product descriptionNemorosone ≥98%
- Packaging10mg
- Price$283
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number24256
- Product descriptionNemorosone ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24256
- Product descriptionNemorosone ≥98%
- Packaging1mg
- Price$49
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number24256
- Product descriptionNemorosone ≥98%
- Packaging5mg
- Price$151
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24256
- Product descriptionNemorosone
- Packaging10mg
- Price$257
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0082127
- Product descriptionNemorosone 99.0%
- Packaging1mg
- Price$112
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-0082127
- Product descriptionNemorosone 99.0%
- Packaging1mg
- Price$112
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01EQ4G | Nemorosone ≥98% | 1mg | $49 | 2026-05-30 | Buy |
| aablocks | AA01EQ4G | Nemorosone ≥98% | 10mg | $283 | 2026-05-30 | Buy |
| aablocks | AA01EQ4G | Nemorosone ≥98% | 5mg | $167 | 2026-05-30 | Buy |
| AK Scientific | 8631CC | Nemorosone | 10mg | $383 | 2021-12-16 | Buy |
| ApexBio Technology | BA3301 | Nemorosone | 1mg | $83 | 2026-05-06 | Buy |
| Cayman Chemical | 24256 | Nemorosone ≥98% | 5mg | $167 | 2026-04-30 | Buy |
| Cayman Chemical | 24256 | Nemorosone ≥98% | 10mg | $283 | 2026-04-30 | Buy |
| Cayman Chemical | 24256 | Nemorosone ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 24256 | Nemorosone ≥98% | 1mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 24256 | Nemorosone ≥98% | 5mg | $151 | 2024-03-01 | Buy |
| Cayman Chemical | 24256 | Nemorosone | 10mg | $257 | 2024-03-01 | Buy |
| ChemScene | CS-0082127 | Nemorosone 99.0% | 1mg | $112 | 2026-06-04 | Buy |
| ChemScene | CS-0082127 | Nemorosone 99.0% | 1mg | $112 | 2026-06-04 | Buy |
Properties
Boiling point :608.9±55.0 °C(Predicted)
Density :1.077±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF:30.0(Max Conc. mg/mL);59.68(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);59.68(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);59.68(Max Conc. mM) form :A crystalline solid
pka :4.50±1.00(Predicted)
color :White to off-white
Density :1.077±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF:30.0(Max Conc. mg/mL);59.68(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);59.68(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);59.68(Max Conc. mM) form :A crystalline solid
pka :4.50±1.00(Predicted)
color :White to off-white
Safety Information
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Description
Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties. Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM). It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nemorosone also inhibits growth of Capan-1, AsPC-1, and MIA-PaCa-2 pancreatic cancer cells (IC50s = 4.5-5.0 μM following a 72-hour treatment) but not human dermal and foreskin fibroblasts (IC50s = >35 μM). It induces apoptosis, abolishes the mitochondrial membrane potential, and increases cytosolic calcium concentration in pancreatic cancer cells in a dose-dependent manner. Nemorosone activates the caspase cascade in a dose-dependent manner and inhibits cell cycle progression, increasing the proportion of cells in the G0/G1 phase, in both neuroblastoma and pancreatic cancer cells. Nemorosone (50 mg/kg, i.p., per day) also reduces tumor growth in an MIA-PaCa-2 mouse xenograft model.Related product price
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Suppliers and manufacturers
BOC Sciences
Shanghai Hongye Biotechnology Co. Ltd
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Shanghai Yifei Biotechnology Co. , Ltd.
TargetMol Chemicals Inc.
Cayman Chemical Company
Enzo Biochem Inc
Qingdao Everest Technology & Trade Co., Ltd.
Guangzhou Chuangze Biotechnology Co., Ltd.
