N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1)
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2物価
選択條件：
ブランド
- 富士フイルム和光純薬株式會社(wako)
パッケージ
- 10mg
- 50mg
- 生産者富士フイルム和光純薬株式會社(wako)
- 製品番號W01TOC4584
- 製品説明
- 英語製品説明SNS 314 mesylate
- 包裝単位10mg
- 価格￥76000
- 更新しました2023-06-01
- 購入
- 生産者富士フイルム和光純薬株式會社(wako)
- 製品番號W01TOC4584
- 製品説明
- 英語製品説明SNS 314 mesylate
- 包裝単位50mg
- 価格￥320000
- 更新しました2023-06-01
- 購入
| 生産者 | 製品番號 | 製品説明 | 包裝単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式會社(wako) | W01TOC4584 | SNS 314 mesylate |
10mg | ￥76000 | 2023-06-01 | 購入 |
| 富士フイルム和光純薬株式會社(wako) | W01TOC4584 | SNS 314 mesylate |
50mg | ￥320000 | 2023-06-01 | 購入 |
プロパティ
貯蔵溫度 :-20°
溶解性 :Soluble in DMSO (up to at least 25 mg/ml).
外見 :solid
色 :Off-white
安定性： :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey :FYCODPVDEFFWSR-UHFFFAOYSA-N
SMILES :[S](=O)(=O)(O)C.[s]1c(ncc1CCNc3ncnc4c3[s]cc4)NC(=O)Nc2cc(ccc2)Cl
溶解性 :Soluble in DMSO (up to at least 25 mg/ml).
外見 :solid
色 :Off-white
安定性： :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey :FYCODPVDEFFWSR-UHFFFAOYSA-N
SMILES :[S](=O)(=O)(O)C.[s]1c(ncc1CCNc3ncnc4c3[s]cc4)NC(=O)Nc2cc(ccc2)Cl
安全情報
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説明
SNS-314 is a pan-Aurora kinase inhibitor (IC50s = 9, 31, and 3.4 nM for Aurora A, B, and C, respectively). In a panel of 219 kinases, SNS-314 also inhibits TRKB, TRKA, FLT4, FMS, DDR2, AXL, and C-RAF (IC50s = 5-100 nM). SNS-314 inhibits Aurora B phosphorylation of histone H3 in HCT116 human colorectal carcinoma cells in vitro (EC50 = <16 nM) and in a mouse xenograft model at a dose of 50 mg/kg. It also inhibits tumor growth in A2780 ovarian, A375 melanoma, H1299 lung, MDA-MB-231 breast, and PC3 prostate cancer mouse xenograft models when administered biweekly for six weeks at a dose of 170 mg/kg.関連商品価格
- ダサチニブ
￥7930-24900 - サラカチニブ
￥8700-600000 - Aurora A Inhibitor I
￥27200-1130200