プロパティ

安全情報(bào)

説明

An effective reagent to introduce difluoromethyl groups into carbonyls, imines, enamines, and alkyl halides. Not only various simple aldehydes and ketones, but also functionalized carbonyls such as α- and γ-ketoesters and cyclic imides can be difluoro(phenylthio)methylated in high yields under the activation of a catalytic amount of Lewis bases. The substitution reaction proceeds well with primary alkyl bromides and iodides as the limiting reactant when cesium fluorode/15-crown-5 is used as the fluoride source/additive. Under radical conditions, the difluoro(phenylthio)methyl compounds containing vinyl functional groups can form 5- or 6-membered rings via intramolecular cyclization.