酢酸ゴセレリン
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- ￥32000 - ￥184000
- 化學(xué)名: 酢酸ゴセレリン
- 英語名: Goserelin acetate
- 別名:ゴセレリン酢酸塩;ゴセレリン酢酸塩 (JAN);ゾラデックス;ゾラデックスLA;ゴセレリン?酢酸
- CAS番號(hào): 145781-92-6
- 分子式: C61H88N18O16
- 分子量: 1329.49
- EINECS:652-995-1
- MDL Number:MFCD00867894
5物価
選択條件：
ブランド
- 富士フイルム和光純薬株式會(huì)社(wako)
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 25mg
- 100mg
- 生産者富士フイルム和光純薬株式會(huì)社(wako)
- 製品番號(hào)W01BCS4038252
- 製品説明
- 英語製品説明(D-Ser(tBu)6,Azagly10)-LHRH, Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2, Acetate
- 包裝単位25mg
- 価格￥126000
- 更新しました2024-03-01
- 購入
- 生産者富士フイルム和光純薬株式會(huì)社(wako)
- 製品番號(hào)W01BCS4038252
- 製品説明
- 英語製品説明(D-Ser(tBu)6,Azagly10)-LHRH, Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2, Acetate
- 包裝単位5mg
- 価格￥32000
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番號(hào)1297205
- 製品説明酢酸ゴセレリン United States Pharmacopeia (USP) Reference Standard
- 英語製品説明Goserelin acetate United States Pharmacopeia (USP) Reference Standard
- 包裝単位100mg
- 価格￥184000
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番號(hào)PHR3776
- 製品説明酢酸ゴセレリン certified reference material, pharmaceutical secondary standard
- 英語製品説明 certified reference material, pharmaceutical secondary standard
- 包裝単位100MG
- 価格￥85500
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番號(hào)G4919
- 製品説明酢酸ゴセレリン ≥99% (HPLC), white powder
- 英語製品説明Goserelin acetate ≥99% (HPLC), white powder
- 包裝単位5mg
- 価格￥38200
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番號(hào) | 製品説明 | 包裝単位 | 価格 | 更新時(shí)間 | 購入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式會(huì)社(wako) | W01BCS4038252 | (D-Ser(tBu)6,Azagly10)-LHRH, Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2, Acetate |
25mg | ￥126000 | 2024-03-01 | 購入 |
| 富士フイルム和光純薬株式會(huì)社(wako) | W01BCS4038252 | (D-Ser(tBu)6,Azagly10)-LHRH, Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2, Acetate |
5mg | ￥32000 | 2024-03-01 | 購入 |
| Sigma-Aldrich Japan | 1297205 | 酢酸ゴセレリン United States Pharmacopeia (USP) Reference Standard Goserelin acetate United States Pharmacopeia (USP) Reference Standard |
100mg | ￥184000 | 2024-03-01 | 購入 |
| Sigma-Aldrich Japan | PHR3776 | 酢酸ゴセレリン certified reference material, pharmaceutical secondary standard certified reference material, pharmaceutical secondary standard |
100MG | ￥85500 | 2024-03-01 | 購入 |
| Sigma-Aldrich Japan | G4919 | 酢酸ゴセレリン ≥99% (HPLC), white powder Goserelin acetate ≥99% (HPLC), white powder |
5mg | ￥38200 | 2024-03-01 | 購入 |
プロパティ
融點(diǎn) :>190°C (dec.)
貯蔵溫度 :-20°C
溶解性 :H2O: 20 mg/mL, clear, colorless
外見 :white powder
色 :White to Off-White
水溶解度 :H2O: 20mg/mL, clear, colorless
安定性： :Hygroscopic
InChIKey :IKDXDQDKCZPQSZ-JHYYTBFNSA-N
貯蔵溫度 :-20°C
溶解性 :H2O: 20 mg/mL, clear, colorless
外見 :white powder
色 :White to Off-White
水溶解度 :H2O: 20mg/mL, clear, colorless
安定性： :Hygroscopic
InChIKey :IKDXDQDKCZPQSZ-JHYYTBFNSA-N
安全情報(bào)
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説明
Goserelin acetate, like leuprolide acetate, is a synthetic superagonist nonapeptide analogue of GnRH that possesses greater potency than the natural hormone. Note that it contains D-Ser(But) and NH-NHCONH2 in place of Gly6 and Gly10-NH2, respectively. That is, the C terminal modification simply has an NH substituting for the CH2 of Gly, and like the C-terminal change in leuprolide acetate, this inhibits enzymatic degradation of the peptide by the postproline carboxyamide peptidase.Goserelin acetate is available in the form of a small, solid pellet that is administered as an SC implant for the palliative treatment of advanced, metastatic breast cancer in pre- and perimenopausal women or, similarly, as a palliative in advanced prostatic cancer. The rationale for this drug's use is, as described above, its ability as a superagonist to bring the levels of estradiol or testosterone to near castrate levels, thus slowing the progression of breast or prostate carcinoma, respectively. Additionally, goserelin acetate is approved for use in treating endometriosis for up to 6 months.