(±)-JQ1
|
2物価
選択條件：
ブランド
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 25mg
- 生産者Sigma-Aldrich Japan
- 製品番號SML0974
- 製品説明 ≥98% (HPLC)
- 英語製品説明(+/-)-JQ1 ≥98% (HPLC)
- 包裝単位25mg
- 価格￥113000
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番號SML0974
- 製品説明 ≥98% (HPLC)
- 英語製品説明(+/-)-JQ1 ≥98% (HPLC)
- 包裝単位5mg
- 価格￥37200
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番號 | 製品説明 | 包裝単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| Sigma-Aldrich Japan | SML0974 | ≥98% (HPLC) (+/-)-JQ1 ≥98% (HPLC) |
25mg | ￥113000 | 2024-03-01 | 購入 |
| Sigma-Aldrich Japan | SML0974 | ≥98% (HPLC) (+/-)-JQ1 ≥98% (HPLC) |
5mg | ￥37200 | 2024-03-01 | 購入 |
プロパティ
沸點 :610.4±65.0 °C(Predicted)
比重(密度) :1.33±0.1 g/cm3(Predicted)
貯蔵溫度 :2-8°C
溶解性 :DMSO: soluble2mg/mL, clear (warmed)
酸解離定數(shù)(Pka) :2.05±0.60(Predicted)
外見 :powder
色 :white to beige
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI :1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3
InChIKey :DNVXATUJJDPFDM-UHFFFAOYSA-N
SMILES :CC1=NN=C2N1C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=NC2CC(OC(C)(C)C)=O
比重(密度) :1.33±0.1 g/cm3(Predicted)
貯蔵溫度 :2-8°C
溶解性 :DMSO: soluble2mg/mL, clear (warmed)
酸解離定數(shù)(Pka) :2.05±0.60(Predicted)
外見 :powder
色 :white to beige
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI :1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3
InChIKey :DNVXATUJJDPFDM-UHFFFAOYSA-N
SMILES :CC1=NN=C2N1C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=NC2CC(OC(C)(C)C)=O
安全情報
| 絵表示(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| 注意喚起語: | ||||||||
| 危険有害性情報: |
|
|||||||
| 注意書き: |
|
説明
(±) JQ1 (1268524-69-1) is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding by (±) JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers.1 Chiral version is available for purchase (Cat#10-1584).関連商品価格
- トログリタゾン
￥10800-233500 - 3-[[[3-[(E)-2-(7-クロロキノリン-2-イル)エテニル]フェニル][[3-(ジメチルアミノ)-3-オキソプロピル]チオ]メチル]チオ]プロパン酸
￥24900-150200 - アダパレン
￥8900-349100
供給者とメーカー
Accela ChemBio Inc.
Hangzhou MolCore BioPharmatech Co.,Ltd.
Nantong HI-FUTURE Biology Co., Ltd.
Aladdin Scientific
Amadis Chemical Company Limited
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Taizhou Tongxin Bio-Tech Co., Ltd
Shanghai YuanQi Biotechnology Co., Ltd.
Sigma-Aldrich
Taizhou Ruixin Chemical Co., Ltd.