(3β-[2-(ジエチルアミノ)エトキシ]アンドロスタ-5-エン-17-オン)·塩酸塩
![(3β-[2-(ジエチルアミノ)エトキシ]アンドロスタ-5-エン-17-オン)·塩酸塩 price.](/CAS/GIF/3039-71-2.gif)
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- ￥15000 - ￥91300
- 化學(xué)名: (3β-[2-(ジエチルアミノ)エトキシ]アンドロスタ-5-エン-17-オン)·塩酸塩
- 英語名: U 18666A
- 別名:(3β-[2-(ジエチルアミノ)エトキシ]アンドロスタ-5-エン-17-オン)·塩酸塩;(3β-[2-(ジエチルアミノ)エトキシ]アンドロスタ-5-エン-17-オン)?塩酸塩;U-18666A
- CAS番號: 3039-71-2
- 分子式: C25H42ClNO2
- 分子量: 424.06
- EINECS:
- MDL Number:MFCD00210908
4物価
選択條件：
ブランド
- 富士フイルム和光純薬株式會社(wako)
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 10mg
- 25mg
- 生産者富士フイルム和光純薬株式會社(wako)
- 製品番號W01W0121-0144
- 製品説明 96.0%(HPLC)
- 英語製品説明U18666A 96.0%(HPLC)
- 包裝単位5mg
- 価格￥15000
- 更新しました2018-12-26
- 購入
- 生産者富士フイルム和光純薬株式會社(wako)
- 製品番號W01TOC1638
- 製品説明
- 英語製品説明U 18666A
- 包裝単位10mg
- 価格￥76000
- 更新しました2023-06-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番號U3633
- 製品説明 powder
- 英語製品説明U 18666A powder
- 包裝単位25mg
- 価格￥91300
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番號U3633
- 製品説明 powder
- 英語製品説明U 18666A powder
- 包裝単位5mg
- 価格￥25800
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番號 | 製品説明 | 包裝単位 | 価格 | 更新時(shí)間 | 購入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式會社(wako) | W01W0121-0144 | 96.0%(HPLC) U18666A 96.0%(HPLC) |
5mg | ￥15000 | 2018-12-26 | 購入 |
| 富士フイルム和光純薬株式會社(wako) | W01TOC1638 | U 18666A |
10mg | ￥76000 | 2023-06-01 | 購入 |
| Sigma-Aldrich Japan | U3633 | powder U 18666A powder |
25mg | ￥91300 | 2024-03-01 | 購入 |
| Sigma-Aldrich Japan | U3633 | powder U 18666A powder |
5mg | ￥25800 | 2024-03-01 | 購入 |
プロパティ
融點(diǎn) :195-196.5 °C(lit.)
貯蔵溫度 :2-8°C
溶解性 :H2O: 9 mg/mL at ≤60 °C
外見 :crystalline
色 :white
水溶解度 :Soluble in water at 10mg/ml
安定性： :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 week.
InChI :1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-9-7-18-8-10-20-21-11-12-23(27)24(21,3)14-13-22(20)25(18,4)17-19;/h8,19-22H,5-7,9-17H2,1-4H3;1H
InChIKey :ICPRVJHNLABCSA-UHFFFAOYSA-N
SMILES :[Cl-].N(CCOC1CC2(C3C(C4C(CC3)(C(=O)CC4)C)CC=C2CC1)C)(CC)CC.[H+]
貯蔵溫度 :2-8°C
溶解性 :H2O: 9 mg/mL at ≤60 °C
外見 :crystalline
色 :white
水溶解度 :Soluble in water at 10mg/ml
安定性： :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 week.
InChI :1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-9-7-18-8-10-20-21-11-12-23(27)24(21,3)14-13-22(20)25(18,4)17-19;/h8,19-22H,5-7,9-17H2,1-4H3;1H
InChIKey :ICPRVJHNLABCSA-UHFFFAOYSA-N
SMILES :[Cl-].N(CCOC1CC2(C3C(C4C(CC3)(C(=O)CC4)C)CC=C2CC1)C)(CC)CC.[H+]
安全情報(bào)
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| 危険有害性情報(bào): |
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説明
Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts. In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.関連商品価格
- RO 48-8071
￥32000-136000 - インポータゾル
￥32300-96000 - Endosidin 2
￥21800-87500
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