| | 1058722-45-4 Basic information More.. |
| Product Name: | 4-Hydroxy-TeriflunoMide | | Synonyms: | 4-Hydroxy-TeriflunoMide;(2Z)-2-Cyano-3,4-dihydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide;WHYQOFDUXDGMTM-KTKRTIGZSA-N;(Z)-2-cyano-3,4-dihydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide;Teriflunomide 4-Hydroxy;2-Butenamide, 2-cyano-3,4-dihydroxy-N-[4-(trifluoromethyl)phenyl]-, (2Z)-;Teriflunomide Impurity 8 | | CAS: | 1058722-45-4 | | MF: | C12H9F3N2O3 | | MW: | 286.21 | | EINECS: | | | Mol File: | 1058722-45-4.mol |  |
Use
4-Hydroxy-Teriflunomide is a metabolite of Leflunomide (L322750), an immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index).
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1058722-45-4
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