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[CAS NO. 5985-28-4]??Synephrine hydrochloride

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PRODUCTS SPECIFICATIONS [5985-28-4]

Catalog
HY-N0132A
Brand
MCE
CAS
5985-28-4

DESCRIPTION [5985-28-4]

Overview

MDL-
Molecular Weight203.67
Molecular FormulaC9H14ClNO2
SMILESOC(C1=CC=C(O)C=C1)CNC.Cl

For research use only. We do not sell to patients.

Summary

Synephrine (Oxedrine) hydrochloride, an alkaloid, is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium . Synephrine hydrochloride is a sympathomimetic compound and can be used for weight loss [1] [2] .


IC50 & Target

Adrenergic receptor [1]


In Vivo

Synephrine (1 mg/kg; oral gavage; for 8 days; PVL and BDL rats) significantly ameliorates the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index are significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance are enhanced by treatment of Synephrine [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Portal vein ligation (PVL) or bile duct ligation (BDL) rats [2]
Dosage: 1 mg/kg per 12 hours
Administration: Oral gavage; for 8 days
Result: The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index were significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance were enhanced.

Appearance

Solid



Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)


Solvent & Solubility

In Vitro:

H 2 O : ≥ 100 mg/mL ( 490.99 mM )

DMSO : ≥ 52 mg/mL ( 255.31 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9099 mL 24.5495 mL 49.0990 mL
5 mM 0.9820 mL 4.9099 mL 9.8198 mL
10 mM 0.4910 mL 2.4550 mL 4.9099 mL
* Please refer to the solubility information to select the appropriate solvent.


Synonyms

Benzenemethanol, 4-hydroxy-α-[(methylamino)methyl]-, hydrochloride (1:1)
Benzyl alcohol, p-hydroxy-α-[(methylamino)methyl]-, hydrochloride
Benzenemethanol, 4-hydroxy-α-[(methylamino)methyl]-, hydrochloride
p-Hydroxy-α-(methylaminomethyl)benzyl alcohol hydrochloride
Synephrine hydrochloride
Oxedrine hydrochloride

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