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Nucleotides and their analogs

The nucleotide is composed by bases, pentose and phosphoric acid, which is the basic unit of biological macromolecules of nucleic acids. Depending on the difference of pentose in nucleotides, they can be divided into ribonucleotides and deoxyribonucleotides, thus constituting two kinds of nucleic acid: ribonucleic acid (RNA) and deoxyribonucleic acid (DNA). The bases composing nucleotide have two types of pyrimidine and purine. Pyrimidine is a 6 ring heterocyclic compound containiong 2 nitrogen atoms, and the common pyrimidine bases in nucleotide include cytosine nucleotides(C), uracil(V)and thymine(T). Purine is a heterocyclic compound containing four nitrogen. Adenine(A) and guanine(G) are the major purine nucleotide base composed nucleotide. Nucleotide is formed by the esterification of sugar hydroxyl groups in nucleoside with phosphated acid after the formation of nucleoside via the condensation of ribose or deoxyribose with bases. The free 5 'nucleotide present in organisms is formed by the esterification of hydroxyl groups of the C5 with pentose phosphate.

Nucleotide is a colorless crystalline powder, which is soluble in water and insoluble in organic solvents. And its solution have optically active, and has a strong UV absorption at 260nm. It is an amphoteric electrolyte, which have different dissociation situations at different pH. These nature has great practical value in the preparation, analysis and measurement of nucleotide.

The application of nucleotide substances is very broad, such as ATP, GTP, 5'- nucleotides, etc. can be used as a supplementary drug; 5'-fluorouracil nucleotide analogs have the anti-cancer effect; poly-cytidine acid is the inducer of interferon and has antiviral activity; in the food industry , inosinic acid and guanylic acid are the co-fresheners of aginomoto, which can greatly increase the flavor of aginomoto; in biological research, nucleotide materials are also the essential reagents.

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Structure Chemical Name CAS MF
6-AZA-2-THIOTHYMINE 6-AZA-2-THIOTHYMINE 615-76-9 C4H5N3OS
1,3-BENZODITHIOLYLIUM TETRAFLUOROBORATE 1,3-BENZODITHIOLYLIUM TETRAFLUOROBORATE 57842-27-0 C7H5BF4S2
5-IODO-1,3-DIMETHYLURACIL 5-IODO-1,3-DIMETHYLURACIL 40738-83-8 C6H7IN2O2
4,5,6-TRIAMINOPYRIMIDINE SULFATE 4,5,6-TRIAMINOPYRIMIDINE SULFATE 6640-23-9 C4H11N5O5S
1,3-Dimethyluric acid 1,3-Dimethyluric acid 944-73-0 C7H8N4O3
DIHYDROTHYMINE DIHYDROTHYMINE 696-04-8 C5H8N2O2
6-Methylpurine 6-Methylpurine 2004-03-7 C6H6N4
1-(4-NITROBENZENESULFONYL)-1H-1,2,4-TRIAZOLE 1-(4-NITROBENZENESULFONYL)-1H-1,2,4-TRIAZOLE 57777-84-1 C8H6N4O4S
5-N-PROPYLURACIL 5-N-PROPYLURACIL 19030-75-2 C7H10N2O2
4,5,6-TRIAMINOPYRIMIDINE SULFATE 4,5,6-TRIAMINOPYRIMIDINE SULFATE 49721-45-1 C4H9N5O4S
2',3'-Dideoxythymidine 2',3'-Dideoxythymidine 3416-05-5 C10H14N2O4
7-METHYLXANTHINE 7-METHYLXANTHINE 552-62-5 C6H6N4O2
N4-ACETYL-2'-DEOXYCYTIDINE N4-ACETYL-2'-DEOXYCYTIDINE 32909-05-0 C11H15N3O5
6-CYANOPURINE 6-CYANOPURINE 2036-13-7 C6H3N5
5-PROPYL-2-THIOURACIL 5-PROPYL-2-THIOURACIL 2954-52-1 C7H10N2OS
6-AMINO-2-HYDROXYPURINE 6-AMINO-2-HYDROXYPURINE 49722-90-9 C10H12N10O6S
7,9-DIMETHYLGUANINE 7,9-DIMETHYLGUANINE 524-35-6 C7H9N5O
URACIL-5-CARBOXYLIC ACID MONOHYDRATE URACIL-5-CARBOXYLIC ACID MONOHYDRATE 69727-34-0 C5H6N2O5
2(1H)-Pyrimidinone, 4-(methylamino)- (9CI) 2(1H)-Pyrimidinone, 4-(methylamino)- (9CI) 6220-47-9 C5H7N3O
Xanthine sodium salt Xanthine sodium salt 1196-43-6 C5H5N4NaO2
DI-TERT-BUTYLCHLOROSILANE DI-TERT-BUTYLCHLOROSILANE 56310-18-0 C8H19ClSi
URIC ACID SODIUM SALT URIC ACID SODIUM SALT 1198-77-2 C5H5N4NaO3
1,N6-ETHENOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT 1,N6-ETHENOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT 103213-51-0 C12H11N5NaO6P
Deoxynucleotide Deoxynucleotide
6-CARBOXY-2,4-DIHYDROXYPYRIMIDINE MONOSODIUM SALT 6-CARBOXY-2,4-DIHYDROXYPYRIMIDINE MONOSODIUM SALT 154-85-8 C5H5N2NaO4
1-CYCLOHEXYLURACIL 1-CYCLOHEXYLURACIL 712-43-6 C10H14N2O2
(E)-5-(2-CARBOXYVINYL)-2,4-DIMETHOXYPYRIMIDINE (E)-5-(2-CARBOXYVINYL)-2,4-DIMETHOXYPYRIMIDINE 119923-27-2 C9H10N2O4
ISOCAFFEINE ISOCAFFEINE 519-32-4 C8H10N4O2
9-ETHYLGUANINE 9-ETHYLGUANINE 879-08-3 C7H9N5O
1-METHYLURIC ACID 1-METHYLURIC ACID 708-79-2 C6H6N4O3
8-AZAXANTHIN 8-AZAXANTHIN 1468-26-4 C4H3N5O2
6-AZAURACIL 6-AZAURACIL 18802-37-4 C3H5N3O2
7-METHYLGUANINE 7-METHYLGUANINE 578-76-7 C6H7N5O
6-AMINO-1,3-DIMETHYL-5-NITROSOURACIL 6-AMINO-1,3-DIMETHYL-5-NITROSOURACIL 6632-68-4 C6H8N4O3
2,4,5-TRIHYDROXYPYRIMIDINE 2,4,5-TRIHYDROXYPYRIMIDINE 20636-41-3 C4H4N2O3
1-METHYLADENINE 1-METHYLADENINE 5142-22-3 C6H7N5
ISOXANTHOPTERIN ISOXANTHOPTERIN 529-69-1 C6H5N5O2
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