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Analytical Chemistry

Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Structure Chemical Name CAS MF
(7R,8R)-Dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucoside (7R,8R)-Dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucoside 351346-10-6 C26H34O11
(6R,9S)-3-Oxo-α-ionol glucoside (6R,9S)-3-Oxo-α-ionol glucoside 159813-37-3 C19H30O7
T-IRR T-IRR
Escitalopram Acid Impurity Escitalopram Acid Impurity 1133881-04-5 C20H22FNO3
1,3,6,10,14-Hexadecapentaene, 3,7,11,15-tetramethyl-, (3E,6E,10E)- 1,3,6,10,14-Hexadecapentaene, 3,7,11,15-tetramethyl-, (3E,6E,10E)- 77898-97-6 C20H32
BROMOCRIPTINE IMPURITY A BROMOCRIPTINE IMPURITY A C32H40BrN5O5
LORATADINE IMPURITY F LORATADINE IMPURITY F C22H23ClN2O2
ZIDOVUDINE IMPURITY A ZIDOVUDINE IMPURITY A
Propanoic acid, 2-[[(Z)-[1-(2-amino-4-thiazolyl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methyl-, 1-(1,1-dimethylethyl) ester Propanoic acid, 2-[[(Z)-[1-(2-amino-4-thiazolyl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methyl-, 1-(1,1-dimethylethyl) ester 330944-50-8 C17H25N5O8S2
Apixaban Impurity 16 Apixaban Impurity 16 2203740-09-2 C26H29N5O5
Canagliflozin Peroxide Impurity Canagliflozin Peroxide Impurity 2247196-28-5 C24H25FO7S
(αR)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-2-naphthalenemethanamine Hydrochloride (αR)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-2-naphthalenemethanamine Hydrochloride 2200269-28-7 C22H23ClF3N
2-(4-Fluorophenyl)-δ-hydroxy-5-(1-methylethyl)-β-oxo-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-Dimethylethyl Ester 2-(4-Fluorophenyl)-δ-hydroxy-5-(1-methylethyl)-β-oxo-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-Dimethylethyl Ester 947262-20-6 C37H41FN2O5
Lucidin 3-O-glucoside Lucidin 3-O-glucoside 22255-29-4 C21H20O10
5-(TRIFLUOROMETHYL)-3-P-TOLYL-1H-PYRAZOLE 5-(TRIFLUOROMETHYL)-3-P-TOLYL-1H-PYRAZOLE 219986-64-8 C11H9F3N2
Bendamustine Impurity 26 Bendamustine Impurity 26
Canagliflozin Impurity 26 Canagliflozin Impurity 26
Edoxaban Impurity 37 Edoxaban Impurity 37 2081883-50-1 C14H27N3O3
5-Methyl-3-phenylisoxazole-4-carboxylic acid 5-Methyl-3-phenylisoxazole-4-carboxylic acid 1136-45-4 C11H9NO3
Imatinib Impurity 10 Imatinib Impurity 10
Levofloxacin Impurity 19 Levofloxacin Impurity 19 C18H20FN3O4
Olanzapine Impurity K Olanzapine Impurity K C17H20N4S
Ticagrelor Related Compound 55 Ticagrelor Related Compound 55
Ticagrelor Related Compound 73 Ticagrelor Related Compound 73
Vildagliptin Impurity 10 Vildagliptin Impurity 10
Cefaclor Impurity 2 Cefaclor Impurity 2 722547-49-1 C17H18N2O3
Cefodizime Impurity F Cefodizime Impurity F
Olaparib Impurity F Olaparib Impurity F
Ornidazole Impurity G Ornidazole Impurity G
Pidotimod Impurity L Pidotimod Impurity L
Tadalafil Impuirty 20 Tadalafil Impuirty 20 2924098-58-6
Tenofovir Impurity 53 Tenofovir Impurity 53
(S)-3-(4-benzylphenoxy)tetrahydrofuran (S)-3-(4-benzylphenoxy)tetrahydrofuran C17H18O2
Ampicillin Ampicillin 1207726-28-0 C24H26N4O5S
ethyl 2-(4-(sec-butoxy)-3-cyanophenyl)-4-methylthiazole-5-
carboxylate ethyl 2-(4-(sec-butoxy)-3-cyanophenyl)-4-methylthiazole-5- carboxylate 2375033-35-3 C18H20N2O3S
(S)-Indacaterol (S)-Indacaterol 1384188-70-8 C24H29ClN2O3
Aripiprazole Impurity 47 Aripiprazole Impurity 47 2250242-47-6 C27H33Cl2N3O3
Aripiprazole Impurity 47 Aripiprazole Impurity 47 2250242-47-6 C27H33Cl2N3O3
Cefminox Sodium  Impurity 3 Cefminox Sodium Impurity 3 1420072-83-8 C16H21N7O6S4
Edaravone Impurity 26 Edaravone Impurity 26 152494-76-3
Levofloxacin Impurity 24 Levofloxacin Impurity 24 C18H20FN3O4
Parecoxib N-Oxide Parecoxib N-Oxide
Rosuvastatin Impurity 84 Rosuvastatin Impurity 84
Pregabalin Impurity PD0224377 Pregabalin Impurity PD0224377 501665-97-0 C14H25NO6
Nintedanib Impurity 24 Nintedanib Impurity 24
2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]
imidazol-5-ol 2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d] imidazol-5-ol 1166386-02-2 C15H15N3O3S
N-((2-(5-methyl-4-phenylisoxazol-3-yl)phenyl)sulfonyl)propionamide N-((2-(5-methyl-4-phenylisoxazol-3-yl)phenyl)sulfonyl)propionamide 2304623-38-7 C19H18N2O4S
Cefminox Impurity 1 Cefminox Impurity 1
Amlodipine Impurity 25 Amlodipine Impurity 25 C26H31ClN2O8S
Axitinib Impurity 13 Axitinib Impurity 13
Axitinib Impurity 18 Axitinib Impurity 18
Erlotinib Impurity 38 Erlotinib Impurity 38
Etoricoxib Impurity 31 Etoricoxib Impurity 31
Nicorandil Impurity 6 Nicorandil Impurity 6
6-amino-1,5-dimethylpyrimidine-2,4(1H,3H)-dione 6-amino-1,5-dimethylpyrimidine-2,4(1H,3H)-dione 63959-47-7 C6H9N3O2
Ciclosporin impurity Ciclosporin impurity 2715287-08-2
Atomoxetine impurity Atomoxetine impurity 42064-62-0 C18H24ClNO
Conivaptan impurity Conivaptan impurity 1129433-63-1 C32H26N4O2
Benzoic acid, 4-(3-hydroxy-1-propenyl)-, ethyl ester Benzoic acid, 4-(3-hydroxy-1-propenyl)-, ethyl ester 89113-43-9 C12H14O3
Lidocaine EP Impurity F Lidocaine EP Impurity F 142713-08-4 C14H22N2O
Ampicillin Impurity P Ampicillin Impurity P
Cefdinir Impurity B (CP) Cefdinir Impurity B (CP)
Cloxacillin Impurity A Cloxacillin Impurity A
Erythromycin Impurity E(EP) Erythromycin Impurity E(EP) 857839-61-3 C37H65NO12
Meropenem Trihydrate Impurity B Meropenem Trihydrate Impurity B 166901-45-7 C34H50N6O10S2
Oxacillin Sodium Impurity D(EP) Oxacillin Sodium Impurity D(EP) 1642559-63-4 C18H21N3O4S
Oxacillin Sodium Impurity J(EP) Oxacillin Sodium Impurity J(EP)
Spectinomycin Impurity A Spectinomycin Impurity A
2,7-Dimethyl-1,4-dihydroxynaphthalene 1-O-glucoside 2,7-Dimethyl-1,4-dihydroxynaphthalene 1-O-glucoside 839711-70-5 C18H22O7
Eriodictyol-6-glucoside Eriodictyol-6-glucoside 118040-45-2 C21H22O11
Rubrofusarin triglucoside Rubrofusarin triglucoside 245724-07-6 C33H42O20
Gabapentin EP Impurity G Gabapentin EP Impurity G 1500558-49-5 C10H19NO2
2-butyrylbenzoic acid 2-butyrylbenzoic acid 19666-03-6 C11H12O3
Cefminox sodium impurities D Cefminox sodium impurities D
(R)-5-chloro-N-(4-(3-oxomorpholino)phenyl)-N- ((2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide (R)-5-chloro-N-(4-(3-oxomorpholino)phenyl)-N- ((2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide 1879903-65-7 C19H18ClN3O5S
Cefmetazole impurity Cefmetazole impurity 56796-19-1 C28H27N7O5S3
3-ethylisobenzofuran-1(3H)-one 3-ethylisobenzofuran-1(3H)-one 17475-41-1 C10H10O2
Ivabradine Impurity 21 HCl Ivabradine Impurity 21 HCl 304465-03-0 C26H34N2O5
Moxifloxacin EP Impurity C HCl Moxifloxacin EP Impurity C HCl
Moxifloxacin Impurity 23 Moxifloxacin Impurity 23 855661-74-4 C21H24FN3O4
Solifenacin Related Compound 18 Solifenacin Related Compound 18 1225338-27-1 C23H26N2O2
N-(2-hydroxy-3-(4-((2-isopropoxyethoxy)methyl)phenoxy)propyl) -N-isopropylformamide N-(2-hydroxy-3-(4-((2-isopropoxyethoxy)methyl)phenoxy)propyl) -N-isopropylformamide 1447715-45-8 C19H31NO5
Tofacitinib Related Compound Tofacitinib Related Compound 1206824-85-2 C10H18ClN3O
Fluvastatin EP impurity A -G Fluvastatin EP impurity A -G 93957-58-5 C24H26FNO4
PWKRNMKZGWGSDV-UHFFFAOYSA-N PWKRNMKZGWGSDV-UHFFFAOYSA-N 1422960-88-0 C33H34ClN4+
sodium:(2S)-2-[12-ethyl-8-(hydroxymethyl)-9-oxo-2-(4-piperidin-1-ylpiperidine-1-carbonyl)oxy-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate sodium:(2S)-2-[12-ethyl-8-(hydroxymethyl)-9-oxo-2-(4-piperidin-1-ylpiperidine-1-carbonyl)oxy-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate 1329502-92-2 C33H41N4NaO7
QFJAHHNMKTWTGZ-DZAPPIOQSA-N QFJAHHNMKTWTGZ-DZAPPIOQSA-N 2045402-27-3 C35H36ClNO4S
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-5,6,7,8-tetrahydro-1-naphthalenecarboxamide N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-5,6,7,8-tetrahydro-1-naphthalenecarboxamide 1374226-74-0 C18H24N2O
BJQMFFOQQWEWAF-DGBYXFBUSA-N BJQMFFOQQWEWAF-DGBYXFBUSA-N 1709825-83-1 C31H41ClO8
4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide 4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide 1216626-17-3 C17H22D5N3O4S
3-Oxo Atorvastatin tert-Butyl Ester 3-Oxo Atorvastatin tert-Butyl Ester 134394-98-2 C37H41FN2O5
(1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(4-fluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(4-fluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol C23H29FN6O4S
(5-Ethyl-1H-imidazol-4-yl)methanol (5-Ethyl-1H-imidazol-4-yl)methanol 38603-74-6 C6H10N2O
(Z)-1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone oxime (Z)-1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone oxime 1810761-43-3 C15H16N2O3S
tert-butyl 2-((4R,6S)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate tert-butyl 2-((4R,6S)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate C14H27NO4
Apixaban Impurity A Apixaban Impurity A
ethylidene phthalide ethylidene phthalide 61658-90-0 C10H8O2
6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl) -7-methyl-7,9-dihydro-8H-purin-8-one 6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl) -7-methyl-7,9-dihydro-8H-purin-8-one 1361569-18-7 C19H15FN8O
Timolol EP Impurity I Timolol EP Impurity I
172967-64-5 172967-64-5 172967-64-5 C18H16ClNO3
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