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J & K SCIENTIFIC LTD.
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18210857532; 18210857532 |
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| Products Intro: |
Product Name:ArteMisinin-d3
CAS:176652-07-6
Package:10Mg,1Mg
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| | Artemisinin-d3 Basic information |
| Product Name: | Artemisinin-d3 | | Synonyms: | (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6-dimethyl-9-(methyl-d3)-3,12-epox-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one;Arteannuin-d3;Artemisine-d3;Artemisinin-d3;Huanghuahaosu-d3;QHS-d3;[2H3]-Artemisinin;3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6-dimethyl-9-(methyl-d3)-, [3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]- (9CI) | | CAS: | 176652-07-6 | | MF: | C15H22O5 | | MW: | 282.33218 | | EINECS: | | | Product Categories: | Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals;Isotope Labelled Compounds;Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 176652-07-6.mol |  |
| | Artemisinin-d3 Chemical Properties |
| Melting point | 156-157°C | | storage temp. | -20°C Freezer | | solubility | DMSO: Slightly soluble,Methanol: Slightly soluble | | form | A solid | | CAS DataBase Reference | 176652-07-6 |
| | Artemisinin-d3 Usage And Synthesis |
| Description | Artemisinin-d3 is intended for use as an internal standard for the quantification of artemisinin . Artemisinin is an endoperoxide antimalarial agent with anticancer activity. It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg. It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day). Artemisinin (100-400 μM) induces cell cycle arrest in the G0/G1 phase and apoptosis and inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells in a time- and concentration-dependent manner. It also suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model. Formulations containing artemisinin have been used in combination therapies for the treatment of malaria. | | Chemical Properties | Crystalline Solid | | Uses | Active antimalarial constituent of the tradional Chinese medicinal herb Artemisia annua L., Compositae, which has been known for almost 2000 years as Qinghao. Antimalarial | | IC 50 | Plasmodium | | References | [1] MONIQUE AKOACHERE. In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins.[J]. Antimicrobial Agents and Chemotherapy, 2005: 4592-4597. DOI: 10.1128/aac.49.11.4592-4597.2005
[2] SHUNQIN ZHU. Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma.[J]. Oncology reports, 2014, 32 3: 1094-1100. DOI: 10.3892/or.2014.3323
[3] ANNE ROBERT. The antimalarial drug artemisinin alkylates heme in infected mice.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 38: 13676-13680. DOI: 10.1073/pnas.0500972102
[4] A.N. CHAWIRA. The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice[J]. Transactions of The Royal Society of Tropical Medicine and Hygiene, 1987, 81 4: Pages 554-558. DOI: 10.1016/0035-9203(87)90404-4 |
| | Artemisinin-d3 Preparation Products And Raw materials |
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