| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:AChE-IN-12
CAS:2764664-52-8
Package:50mg/RMB 19420;100mg/RMB 24625;25mg/RMB 14900
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AChE-IN-12 manufacturers
- AChE-IN-12
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- $2785.00
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2026-05-11
- CAS:2764664-52-8
- Purity:
- Supply Ability: 10g
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| | AChE-IN-12 Basic information |
| | AChE-IN-12 Chemical Properties |
| Boiling point | 741.9±60.0 °C(Predicted) | | density | 1.167±0.06 g/cm3(Predicted) | | pka | 7.62±0.50(Predicted) |
| | AChE-IN-12 Usage And Synthesis |
| Uses | AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC50s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC50 = 8.8μM). AChE-IN-12 has remarkable inhibition of self- and Cu2+-induced Aβ1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease[1]. | | IC 50 | AChE | | References | [1] Sang Z, Song Q, Cao Z, Deng Y, Zhang L. Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2022;37(1):69-85. DOI:10.1080/14756366.2021.1993845 |
| | AChE-IN-12 Preparation Products And Raw materials |
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