|
|
| | (1S,4R)-4-Amino-2-cyclopenten-1-carboxylic Acid Hydrochloride Basic information |
| Product Name: | (1S,4R)-4-Amino-2-cyclopenten-1-carboxylic Acid Hydrochloride | | Synonyms: | 2-Cyclopentene-1-carboxylicacid,4-amino-,(1S,4R)-(9CI);2-Cyclopentene-1-carboxylic acid, 4-aMino-, (1S,4R)-;(1S,4R)-4-Amino-2-cyclopenten-1-carboxylic Acid Hydrochloride;Cis(1S,4R)-4-aMino-2-Cyclopentene-1-carboxylic acid;(1S,4R)-4-Amino-2-cyclopenten-1-carboxylic Acid;Peramivir Impurity 14 HCl;1-Piperidinecarboxylicacid,4-(2-bromoethyl)-,1,5-dimethylethylester;(1S,4R)-4-Amino-2-cyclopentenecarboxylic Acid | | CAS: | 134234-04-1 | | MF: | C6H9NO2 | | MW: | 127.14 | | EINECS: | | | Product Categories: | AMINOACID | | Mol File: | 134234-04-1.mol |  |
| | (1S,4R)-4-Amino-2-cyclopenten-1-carboxylic Acid Hydrochloride Chemical Properties |
| Melting point | >260 °C (decomp)(Solv: water (7732-18-5); acetone (67-64-1)) | | Boiling point | 266.6±40.0 °C(Predicted) | | density | 1.248±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 3.52±0.20(Predicted) | | Appearance | Off-white to light brown Solid | | Optical Rotation | Consistent with structure | | InChI | InChI=1S/C6H9NO2/c7-5-2-1-4(3-5)6(8)9/h1-2,4-5H,3,7H2,(H,8,9)/t4-,5+/m1/s1 | | InChIKey | VTCHZFWYUPZZKL-UHNVWZDZSA-N | | SMILES | [C@H]1(C(O)=O)C[C@@H](N)C=C1 |
| | (1S,4R)-4-Amino-2-cyclopenten-1-carboxylic Acid Hydrochloride Usage And Synthesis |
| Uses | (1S,4R)-4-Amino-2-cyclopenten-1-carboxylic Acid is a γ-aminobutyric acid mimetic drug that affect dopaminergic activity. | | Synthesis | Dissolve 10g of (1S, 4R)-4-aminocyclopent-2-ene-1-carboxylic acid methyl ester tartrate in 50mL of methanol, add triethylamine to neutralize to Ph6-7, add 10mL of water and cool to -20 , 5mL of lithium hydroxide aqueous solution (containing 0.16g of lithium hydroxide) was added dropwise, immediately after the reaction was neutralized with acetic acid to pH 3-4, the organic solvent was vortexed and diluted with tetrahydrofuran, the salt was filtered off and vortexed to obtain (1S,4R)-4-Amino-2-cyclopenten-1-carboxylic Acid Hydrochloride 3.6 g, yield 83.7%. | | References | [1] Tetrahedron Asymmetry, 2016, vol. 27, # 16, p. 729 - 731 |
| | (1S,4R)-4-Amino-2-cyclopenten-1-carboxylic Acid Hydrochloride Preparation Products And Raw materials |
|