外消旋-莫地帕泛
| 中文名稱 | 外消旋-莫地帕泛 |
|---|---|
| 中文同義詞 | 外消旋-莫地帕泛;2-[4-(2-甲基-1H-咪唑并[4,5-C]吡啶-1-基)苯基]-4-(2-氯苯基)-5-[(2-吡啶基氨基)羰基]-6- 甲基-1,4-二氫吡啶-3-羧酸乙酯;化合物 T28081;化合物 (RAC)-MODIPAFANT |
| 英文名稱 | Rac-Modipafant |
| 英文同義詞 | 2-[4-(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-4-(2-chlorophenyl)-5-[(2-pyridinylamino)carbonyl]-6-methyl-1,4-dihydropyridine-3-carboxylic acid ethyl ester;Modipefant;UK-74505;4-(2-Chlorophenyl)-1,4-dihydro-6-Methyl-2-[4-(2-Methyl-1H-iMidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylaMino)carbonyl]-3-pyridinecarboxylic Acid Ethyl Ester;rac-Modipafant;ethyl 4-(2-chlorophenyl)-6-methyl-2-(4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl)-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate(WXG02205);3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester;Modipafant racemate |
| CAS號 | 122956-68-7 |
| 分子式 | C34H29ClN6O3 |
| 分子量 | 605.09 |
| EINECS號 | |
| 相關類別 | Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 122956-68-7.mol |
| 結構式 |  |
外消旋-莫地帕泛 性質
| 密度 | 1.34±0.1 g/cm3 (20 ºC 760 Torr) |
|---|---|
| 儲存條件 | Store at -20°C |
| 酸度系數(pKa) | 12.14±0.70(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 淺黃至黃色 |
(Rac)-Modipafant (UK-74505) 是一種口服的、選擇性的、長效的不可逆血小板活化因子受體 (PAFR) 受體拮抗劑。(Rac)-Modipafant 預防嚴重登革熱感染。
(Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection.
(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC
50
=26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively).
(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia.
| Animal Model: | 8- to 10-week-old BALB/c mice (DEN-2 strain infected) |
| Dosage: | 10 mg/kg |
| Administration: | P.o.; twice a day (started on days 0, 3, 5, or 7) until day 10 |
| Result: | Decreased by approximately 50% the lethality associated with DEN-2 infection. |
| Animal Model: | Male BALB/C (8- to 10- week-old) wild-type mice |
| Dosage: | 5, 10 and 20 mg/kg |
| Administration: | P.o. |
| Result: | Dose-dependently inhibited the Zymosan -induced articular hyperalgesia. |
安全信息
| 更新日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-108908 | 外消旋-莫地帕泛 (Rac)-Modipafant | 122956-68-7 | 1 mg | 3288元 |
| 2026/06/05 | HY-108908 | 外消旋-莫地帕泛 (Rac)-Modipafant | 122956-68-7 | 10 mM * 1 mLin DMSO | 10450元 |