| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:P-gb-IN-1
CAS:2632874-49-6
Purity:99% Package:1mg;5mg;10mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:P-gb-IN-1
CAS:2632874-49-6
Purity:99.85% Package:1removed
|
P-gb-IN-1 manufacturers
- P-gb-IN-1
-
- $82.00
-
2026-05-28
- CAS:2632874-49-6
- Purity: 99.85%
- Supply Ability: 10g
|
| | P-gb-IN-1 Basic information |
| Product Name: | P-gb-IN-1 | | Synonyms: | P-gb-IN-1;Benzamide, N-[4-[5-[(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)carbonyl]-2-furanyl]phenyl]-4-methoxy-;N-(4-(5-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)furan-2-yl)phenyl)-4-methoxybenzamide | | CAS: | 2632874-49-6 | | MF: | C30H28N2O6 | | MW: | 512.55 | | EINECS: | | | Product Categories: | | | Mol File: | 2632874-49-6.mol |  |
| | P-gb-IN-1 Chemical Properties |
| Boiling point | 660.934±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.271±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 12.935±0.70(predicted) |
| | P-gb-IN-1 Usage And Synthesis |
| Uses | P-gb-IN-1 (compound Ⅲ-8), a 2,5-disubstituted furan derivative, is a highly effective, broadspectrum P-glycoprotein (P-gp) inhibitor. P-gb-IN-1 displayed the reversal activity by inhibiting P-gp efflux. P-gb-IN-1 has a potent affinity to P-gp by forming H-bond interactions with residues Asn 721 and Met 986. P-gb-IN-1 possesses broad-spectrum reversal activity and low toxicity in MCF-7/ADR cells[1]. | | References | [1] Zhikun Yang, et al. Discovery of 2,5-disubstituted furan derivatives featuring a benzamide motif for overcoming P-glycoprotein mediated multidrug resistance in MCF-7/ADR cell. Eur J Med Chem. 2023 Sep 5;257:115462. DOI:10.1016/j.ejmech.2023.115462 |
| | P-gb-IN-1 Preparation Products And Raw materials |
|