STING-IN-5

STING-IN-5 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: 13564774135
Email: marketing@targetmol.com
Products Intro: Product Name:STING-IN-5
CAS:2920064-17-9
Package:100mg;3700USD|50mg;2780USD|5mg;1370USD
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:STING-IN-5
CAS:2920064-17-9
Package:1removed
Company Name: Zhejiang Huida Biotech Co., Ltd.  
Tel: 0571-89903022 18679456698
Email: zilong@hizyme.com
Products Intro: Product Name:STING-IN-5
CAS:2920064-17-9
Purity:>=98% Package:100mg；200mg

STING-IN-5 manufacturers

  • STING-IN-5
  • STING-IN-5 pictures
  • $3700.00
  • 2026-07-27
  • CAS:2920064-17-9
  • Purity:
  • Supply Ability: 10g
STING-IN-5 Basic information
Product Name:STING-IN-5
Synonyms:STING-IN-5;29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-11-hydroxy-3-[1-oxo-3-[[3-oxo-3-[(2-propen-1-yloxy)amino]propyl]dithio]propoxy]-, phenylmethyl ester, (3α,4α,8α,9β,11α,13α,14β,16β,17Z)-
CAS:2920064-17-9
MF:C47H67NO9S2
MW:854.17
EINECS:
Product Categories:
Mol File:2920064-17-9.mol
STING-IN-5 Structure
STING-IN-5 Chemical Properties
density 1.20±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka14.44±0.70(predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
STING-IN-5 Usage And Synthesis
UsesSTING-IN-5 is a potent STING inhibitor, inhibiting LPS-induced NO synthesis in macrophages with an IC50 value of 1.15 μM. STING-IN-5 inhibits the inflammatory response. STING-IN-5 can be used to research anti-inflammatory diseases and sepsis[1].
in vivo

STING-IN-5 (1.25-5 mg/kg; i.g.; once daily; for 3 days) have an obvious protective effect on acute liver injury in septic mice[1].
Pharmacokinetic Parameters of STING-IN-5 in male Sprague-Dawley rats[1].

Tmax (h)Cmax (ng/mL)AUC0-t (ng/mL·h)AUC0-∞ (ng/mL·h)T1/2 (h)MRT0-t (h)MRT0-∞ (h)
166.5281.08135.71.110.992.02
Animal Model:Male BALB/c mice (6-8 weeks; acute liver injury induced by injection of 10 mg/kg LPS)[1]
Dosage:1.25, 2.5, 5 mg/kg
Administration:i.g.; once daily; for 3 days
Result:Significantly improved pathological changes including disorderly arranged liver cells, blurred boundaries, congested hepatic sinusoids, swollen hepatocytes, a small number of hepatocytes were necrotic, and inflammatory cells infiltrated local areas.
Significantly reduced the levels of AST, ALT, and ALP (liver function specific indicators).
References[1] Long J, et al. Discovery of fusidic acid derivatives as novel STING inhibitors for treatment of sepsis. Eur J Med Chem. 2022 Dec 15;244:114814. DOI:10.1016/j.ejmech.2022.114814
STING-IN-5 Preparation Products And Raw materials
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