N-(4,4-diphenylbutan-2-yl)-2-methyl-propan-2-amine hydrochloride
生物活性靶點(diǎn)體內(nèi)研究 用途與合成方法 MSDS N-(4,4-diphenylbutan-2-yl)-2-methyl-propan-2-amine hydrochloride價(jià)格(試劑級(jí)) 上下游產(chǎn)品信息
| 中文名稱 | N-(4,4-diphenylbutan-2-yl)-2-methyl-propan-2-amine hydrochloride |
|---|---|
| 中文同義詞 | 鹽酸特羅地林;化合物 T13129;【進(jìn)口原裝】Terodiline hydrochloride/7082-21-5;【進(jìn)口原裝】Terodiline hydrochloride/7082-21-5 |
| 英文名稱 | N-(4,4-diphenylbutan-2-yl)-2-methyl-propan-2-amine hydrochloride |
| 英文同義詞 | N-(4,4-diphenylbutan-2-yl)-2-methyl-propan-2-amine hydrochloride;Terodilin hydrochloride;Bicor, N-(1,1-Dimethylethyl)-alpha-methyl-gamma-phenylbenzenepropamine hydrochloride;Terodiline hydrochloride;Mictrol;N-(1,1-Dimethylethyl)-alpha-methyl-gamma-phenylbenzenepropamine hydrochloride;Terodiline hydrochloride >=98% (HPLC), solid |
| CAS號(hào) | 7082-21-5 |
| 分子式 | C20H28ClN |
| 分子量 | 0 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 7082-21-5.mol |
| 結(jié)構(gòu)式 |  |
N-(4,4-diphenylbutan-2-yl)-2-methyl-propan-2-amine hydrochloride 性質(zhì)
| 熔點(diǎn) | 178-180° |
|---|---|
| 儲(chǔ)存條件 | −20°C |
| 溶解度 | 二甲基亞砜：>20mg/mL |
| 形態(tài) | 固體 |
| 顏色 | 白色至類白色 |
| InChI | 1S/C20H27N.ClH/c1-16(21-20(2,3)4)15-19(17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,16,19,21H,15H2,1-4H3;1H |
| InChIKey | RNGHAJVBYQPLAZ-UHFFFAOYSA-N |
| SMILES | Cl.CC(CC(c1ccccc1)c2ccccc2)NC(C)(C)C |
Terodiline hydrochloride 是一種 M1 選擇性的毒蕈堿受體 (muscarinic receptor; mAChR) 拮抗劑。 對(duì)兔輸精管 (M1)，心房 (M2)，膀胱 (M3)，回腸肌 (M3) 的 Kb 分別為 15，160，280，和 198 nM。Terodiline hydrochloride 還是鈣通道 (Ca2+) 阻斷劑。Terodiline hydrochloride 可用于尿頻和急迫性尿失禁的研究。
mAChR
Ca
2+
channel
Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID 50 = 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED 50 =59 mg/kg).
| Animal Model: | Fmale or male Hartley guinea pigs (200-600 g) |
| Dosage: | 80 mg/kg |
| Administration: | Administered S.C. |
| Result: | Yielded an ID 50 of 24±6 mg/kg. Higher doses were Iethal. |