- Ac-YVAD-CMK
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- $64.00
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2026-04-22
- CAS:178603-78-6
- Purity: 99.90%
- Supply Ability: 10g
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| | AC-YVAD-CMK Basic information |
| | AC-YVAD-CMK Chemical Properties |
| Melting point | >205°C (dec.) | | RTECS | AY3079566 | | storage temp. | -20°C | | solubility | DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated) | | form | White solid | | color | white to off-white | | Stability: | Hygroscopic | | InChIKey | CQZPAKWASFYDKD-DGJUNBOTSA-N | | SMILES | C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(C)=O)[C@@H](CC(O)=O)C(=O)CCl |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | AC-YVAD-CMK Usage And Synthesis |
| Uses | Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Ac-YVAD-CMK is neuroprotective in a rat model of cerebral ischemia.[Cayman Chemical] | | Uses | Ac-YVAD-cmk has been used:
- as an inflammasome inhibitor to add to THP-1 cells or PBMC (peripheral blood mononuclear cell) before stimulation
- as a caspase-1 inhibitor injected to C57BL/6 mice
- as a caspase-1 inhibitor, administered into mice before and during hematopoietic stem cell transplantation (HSCT) to evaluate its effect on bone marrow inflammatory injury
- to abolish the histidine-rich protein II (HRPII) effect on transendothelial electrical resistance (TEER)
- as caspase 1 inhibitor, to treat MCF-7 tumor xenograft mice, to validate the role of inflammasomes activation in tumor growthin vivocondition
| | General Description | Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation. | | Biochem/physiol Actions | Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. Ac-YVAD-cmk is anti-apoptotic and has anti-inflammatory and neuroprotective effects, thought to result from its preventing caspase-1 activation of the proinflammatory cytokine, Interleukin-1β. | | in vivo | Ac-YVAD-cmk treatment (1 μg/rats; SD rat; injected into the left lateral ventricle) significantly decreases the protein levels of caspase-1 (p20), mature IL-1β/IL-18 compared with the ICH group[2].
Ac-YVAD-cmk (rats with ac-YVAD-cmk at a dose of 12.5 μmol/kg) significantly reduces mortality from 83 to 33% using Log Rank analysis[3]. | | IC 50 | Caspase-1 |
| | AC-YVAD-CMK Preparation Products And Raw materials |
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