- H-ALPHA-ME-D-PRO-OH
-
- $9.90
-
2026-03-20
- CAS:63399-77-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- H-ALPHA-ME-D-PRO-OH
-
- $3.00
-
2025-05-26
- CAS:63399-77-9
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 100000
- 2-Methyl-D-proline
-
-
2024-11-26
- CAS:63399-77-9
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1 ton
|
| | H-ALPHA-ME-D-PRO-OH Basic information |
| Product Name: | H-ALPHA-ME-D-PRO-OH | | Synonyms: | (R)-2-Methylpyrrolidine-2-carboxylic acid;H-alpha-Methyl-D-proline;2-Methyl-D-proline hydroc...;(R)-a-Methyl-proline;2-Methyl-D-proline hydrochloride;α-Me-D-Pro-OH;H-ALPHA-ME-D-PRO-OH;D-ALPHA-METHYLPROLINE | | CAS: | 63399-77-9 | | MF: | C6H11NO2 | | MW: | 129.16 | | EINECS: | 2017-001-1 | | Product Categories: | GLYCINESCAFFOLD | | Mol File: | 63399-77-9.mol |  |
| | H-ALPHA-ME-D-PRO-OH Chemical Properties |
| Melting point | 340℃ (DEC.) | | Boiling point | 241.9±33.0 °C(Predicted) | | density | 1.119 | | storage temp. | Sealed in dry,Room Temperature | | pka | 2.44±0.20(Predicted) | | form | powder | | color | White | | Optical Rotation | 76.369°(C=0.01g/ml MEOH) |
| | H-ALPHA-ME-D-PRO-OH Usage And Synthesis |
| Uses | (R)-2-Methyl Proline is a derivative of D-Proline (P755990) which is used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C. | | Synthesis | The general procedure for the synthesis of (S)-2-methylproline and (R)-2-methylpyrrolidine-2-carboxylic acid from the compounds (CAS: 848488-83-5) is as follows: (R)-α-methylproline amide (0.40 g, 58% purity, 1.78 mmol) prepared in Reference Example 4 was added to a reaction flask with 6 M hydrochloric acid (2 mL) and stirred at 90°C for The reaction was carried out for 4 hours. Upon completion of the reaction, the product was analyzed by high performance liquid chromatography (HPLC) to confirm the presence of (R)-α-methylproline (204 mg, 1.58 mmol) in 90% yield and 89% ee optical purity. | | References | [1] Patent: EP2716629, 2014, A1. Location in patent: Paragraph 0208; 0209
[2] Patent: JP5959417, 2016, B2. Location in patent: Paragraph 0175 |
| | H-ALPHA-ME-D-PRO-OH Preparation Products And Raw materials |
|