Related articles - How to buy Enclomiphene (Citrate)?
- Enclomiphene is a non-steroidal estrogen receptor antagonist that is a prescription drug used as a low testosterone treatment ....
- Feb 27，2024
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| | trans-Clomiphene Citrate Basic information |
| Product Name: | trans-Clomiphene Citrate | | Synonyms: | trans-Clomiphene citrate;Triethylamine, 2-(p-(2-chloro-1,2-diphenylvinyl)phenoxy)-, citrate, (E)-;Unii-J303A6U9Y6;(E)-Clomiphene citrate;Clomiphene B citrate;Enclomid;Enclomiphene Citrate /trans-Clomiphene;Enclomiphene CitrateQ: What is
Enclomiphene Citrate Q: What is the CAS Number of
Enclomiphene Citrate Q: What is the storage condition of
Enclomiphene Citrate Q: What are the applications of
Enclomiphene Citrate | | CAS: | 7599-79-3 | | MF: | C26H28ClNO.C6H8O7 | | MW: | 598.08 | | EINECS: | 000-000-0 | | Product Categories: | Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals;API | | Mol File: | 7599-79-3.mol |  |
| | trans-Clomiphene Citrate Chemical Properties |
| Melting point | 143-145°C | | storage temp. | Amber Vial, -20°C Freezer | | solubility | DMSO (Slightly), Ethyl Acetate (Slightly, Heated, Sonicated) | | form | Solid | | color | White to Off-White | | Stability: | Light Sensitive | | InChIKey | PYTMYKVIJXPNBD-BTKVJIOYSA-N |
| | trans-Clomiphene Citrate Usage And Synthesis |
| Chemical Properties | Enclomiphene citrate is chemically an organic citrate with good photoluminescent properties in organic solutions due to the presence of a tristyrene unit in its structure. Due to the presence of a tertiary amine unit in the structure, it is sensitive to oxidants and is easily oxidized by oxidants to the corresponding nitrogen oxides. | | Uses | trans-Clomiphene Citrate, stereoisomer of Clomiphene Citrate (C587025), a synthetic estrogen agonist-antagonist. Gonad-stimulating principle. | | Toxicology | The effects of the cis and trans isomers of clomiphene citrate on the uterine hexokinase activity of immature ovariectomized rats were studied in long- and short-term experiments. At a dose level of 600 μg/kg, both trans-Clomiphene Citrate and cis-Clomiphene Citrate caused a similar increase in total uterine hexokinase activity observable in 18 hr. When enzyme activity was expressed per g of the uterus (specific activity), significant increases were noted 18 hr after a single injection of trans clomiphene or after 4 daily injections of either isomer. Treatment of these animals with 170-estradiol (5 μg/kg) caused an elevation of both the specific and total hexokinase activities within 18 hr[1].
| | in vivo | Enclomiphene citrate (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats[5].
Enclomiphene citrate (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol[6]. | Animal Model: | 21 days-old Charles River male rats[5] | | Dosage: | 0.25 and 0.5 mg/animal, daily for 24 days. | | Administration: | Subcutaneous injection | | Result: | Decreased LH and testosterone levels in the serum. |
| Animal Model: | OVX (ovariectomy) rat model[6] | | Dosage: | 0.03, 1, and 3 mg/kg, daily for 90 days. | | Administration: | Oral adminstration | | Result: | Reducted body weight to sham levels, and reduced serum cholesterol.
Showed dose-dependent effects on the proximal tibia with BMD and BMC approaching posttreatment Sham levels.
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| | References | [1] D L DiPietro, D A Goss, F J Sanders. “Effect of cis and trans isomers of clomiphene citrate on uterine hexokinase activity.” Endocrinology 84 6 (1969): 1404–8. |
| | trans-Clomiphene Citrate Preparation Products And Raw materials |
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