KF31327
| 中文名稱 | KF31327 |
|---|---|
| 中文同義詞 | 西地那非雜質(zhì)35;化合物 T26273;硫喹哌非;化合物 THIOQUINAPIPERIFIL;硫喹哌非 (標準品) |
| 英文名稱 | KF31327 |
| 英文同義詞 | KF31327;3-ethyl-8-[[2-[4-(hydroxymethyl)piperidin-1-yl]phenyl]methylamino]-1H-imidazo[4,5-g]quinazoline-2-thione;Thioquinapiperifil;2H-Imidazo[4,5-g]quinazoline-2-thione, 3-ethyl-1,3-dihydro-8-[[[2-[4-(hydroxymethyl)-1-piperidinyl]phenyl]methyl]amino]-;KF-31327 free base;Thioquinapiperifil (Standard);Thioquinapiperfil |
| CAS號 | 220060-39-9 |
| 分子式 | C24H28N6OS |
| 分子量 | 448.59 |
| EINECS號 | |
| 相關類別 | |
| Mol文件 | 220060-39-9.mol |
| 結(jié)構(gòu)式 |  |
KF31327 性質(zhì)
| 沸點 | 676.558±65.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| 密度 | 1.384±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| 酸度系數(shù)(pKa) | 10.425±0.30(predicted) |
|
PDE5 0.074 nM (IC 50 ) |
PDE1 380 nM (IC 50 ) |
PDE2 670 nM (IC 50 ) |
PDE3 38 nM (IC 50 ) |
PDE4 800 nM (IC 50 ) |
Thioquinapiperifil can be found in dietary supplements.
Thioquinapiperifil (KF31327 free base) (0.1-10 μM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 μM of Thioquinapiperifil (KF31327 free base) are required to inhibit platelet aggregation.
Thioquinapiperifil (KF31327 free base) and shows significant increase in cyclic GMP at 10 μM. After 5 min incubation, the mean cyclic GMP levels of Thioquinapiperifil (KF31327)-treated cells is 0.95±0.17 pmol/10
8
cells.