| Company Name: |
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
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| Tel: |
17702719238 18971495150; |
| Email: |
sales@sun-shinechem.com |
| Products Intro: |
Product Name:EX-527(S)
CAS:848193-68-0
Purity:98% HPLC Package:50.0mg;100.0mg; 200.0mg;500mg;1g;5g; 10g
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| Product Name: | EX527 | | Synonyms: | EX527;(1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide;EX-527(S);EX-527(S),(1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxaMide;EX-527 (S-enantioMer);Selisistat S-enantiomer(EX-527 S-enantiomer);Selisistat S-enantiomer;CS-573 | | CAS: | 848193-68-0 | | MF: | C13H13ClN2O | | MW: | 248.71 | | EINECS: | | | Product Categories: | | | Mol File: | 848193-68-0.mol |  |
| | EX527 Chemical Properties |
| Boiling point | 531.7±38.0 °C(Predicted) | | density | 1.388 | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 16.12±0.40(Predicted) | | form | Powder | | color | Light yellow to yellow |
| | EX527 Usage And Synthesis |
| Uses | (S)-Selisistat ((S)-EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM. | | Definition | ChEBI: (S)-selisistat is a 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide that has S configuration It is the active enantiomer. It has a role as a Sir1 inhibitor. It is an enantiomer of a (R)-selisistat. | | in vivo | (S)-Selisistat abolishes Resveratrol (RSV)-induced attenuation of microvascular inflammation in ob/ob septic mice. Finally, ob/ob mice in Sepsis+RSV group has significantly increased 7-day survival vs. Sepsis+Vehicle group[3]. | | IC 50 | SIRT1: 98 nM (IC50) | | References | [1] Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26(1):28-38. DOI:10.1128/MCB.26.1.28-38.2006
[2] Jia Y, et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20;10(3):e0120849. DOI:10.1371/journal.pone.0120849
[3] Wang X, et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015 Jun;23(6):1209-17. DOI:10.1002/oby.21086
[4] Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54. DOI:10.1021/jm050522v |
| | EX527 Preparation Products And Raw materials |
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