2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2)

2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2) Suppliers list
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Products Intro: Product Name:N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide,4-methylbenzenesulfonic acid
CAS:451493-31-5
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Products Intro: Product Name:AV-412
CAS:451493-31-5
Purity:99.85% Package:1mg;37USD|2mg;53USD|5mg;87USD Remarks:REAGENT;FOR LABORATORY USE ONLY
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CAS:451493-31-5
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CAS:451493-31-5
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2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2) manufacturers

  • AV-412
  • AV-412 pictures
  • $37.00
  • 2026-05-11
  • CAS:451493-31-5
  • Purity: 99.92%
  • Supply Ability: 10g
  • AV-412
  • AV-412 pictures
  • $37.00
  • 2026-05-11
  • CAS:451493-31-5
  • Purity: 99.92%
  • Supply Ability: 10g
2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2) Basic information
Product Name:2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2)
Synonyms:2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2);AV-412 / MP-412;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-6-quinazolinyl]-2-propenamide bis(4-methylbenzenesulfonate);AV-412 Tosylate;MP-412;MP412;N-[4-(3-Chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide tosylate;MP-412;AV412;AV 412;MP412;MP 412;N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide,4-methylbenzenesulfonic acid
CAS:451493-31-5
MF:C41H44ClFN6O7S2
MW:851.4054632
EINECS:
Product Categories:
Mol File:451493-31-5.mol
2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2) Structure
2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2) Chemical Properties
storage temp. Store at -20°C
solubility DMSO:21.5(Max Conc. mg/mL);25.29(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.29(Max Conc. mM)
DMF:15.0(Max Conc. mg/mL);17.64(Max Conc. mM)
Ethanol:0.25(Max Conc. mg/mL);0.29(Max Conc. mM)
form Powder
color Light yellow to green yellow
Safety Information
MSDS Information
2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2) Usage And Synthesis
UsesAV 412 is EGFR/HER2 inhibitor. It can be used in pharmacological activity and biological study of light-assisted small-molecule screening against protein kinases.
Biological ActivityAV-412 (MP412) is an EGFR inhibitor with IC50 values of 0.75, 0.5, 0.79, 2.3 and 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.
in vitro

AV-412 inhibits autophosphorylation of EGFR and ErbB2 with IC 50 of 43 and 282 nM, respectively. It also inhibits epidermal growth factor (EGF)-dependent cell proliferation with an IC 50 of 100 nM. It abrogates EGFR signaling in the gefitinib-resistant H1975 cell line, which harbors a double mutation of L858R and T790M in EGFR.

in vivoIn animal studies using cancer xenograft models, AV-412 (30 mg/kg) demonstrates complete inhibition of tumor growth of the A431 and BT-474 cell lines, which overexpress EGFR and ErbB2, respectively.
target

EGFR

0.75 nM (IC 50 )

EGFR L858R

0.5 nM (IC 50 )

EGFR T790M

0.79 nM (IC 50 )

EGFR < sup> L858R/T790M

2.3 nM (IC 50 )

ErbB2

19 nM (IC 50 )

IC 50EGFR: 0.75 nM (IC50); EGFRL858R: 0.5 nM (IC50); EGFRT790M: 0.79 nM (IC50); EGFRL858R/T790M: 2.3 nM (IC50); ErbB2: 19 nM (IC50)
2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2) Preparation Products And Raw materials
Tag:2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2)(451493-31-5) Related Product Information