ChemicalBook > Product Catalog >Biochemical Engineering >Biochemical Reagents >Agonist Inhibitors >Tiprolisant oxalate

Tiprolisant oxalate

Tiprolisant oxalate Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:Pitolisant oxalate
CAS:362665-57-4
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:Pitolisant oxalate;Tiprolisant oxalate
CAS:362665-57-4
Purity:98.00% Package:1 mL * 10mM (in DMSO);10 mg;100 mg;200 mg;50 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:PITOLISANT OXALATE
CAS:362665-57-4
Purity:98% Package:5mg Remarks:V4309
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:Pitolisant oxalate
CAS:362665-57-4
Package:50mg;1980USD|100mg;2500USD|25mg;1520USD
Company Name: Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel: +8613720134139
Email: orders@jknbiochem.com
Products Intro: Product Name:Pitolisant oxalate
CAS:362665-57-4
Purity:0.98 Package:10G:100G

Tiprolisant oxalate manufacturers

Tiprolisant oxalate Basic information
Product Name:Tiprolisant oxalate
Synonyms:Pitolisant (oxalate);Tiprolisant oxalate;1-[3-[3-(4-Chlorophenyl)propoxy]propyl]piperidine ethanedioate (1:1);Pitolisant ethanedioate (1:1)
CAS:362665-57-4
MF:C19H28ClNO5
MW:385.88232
EINECS:
Product Categories:
Mol File:362665-57-4.mol
Tiprolisant oxalate Structure
Tiprolisant oxalate Chemical Properties
storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (129.57 mM; Need ultrasonic)
form Powder
color Off-white to light yellow
Safety Information
MSDS Information
Tiprolisant oxalate Usage And Synthesis
UsesPitolisant oxalate is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).
in vivo

The administration of Pitolisantat a single dose of 10 mg/kg 30 min before a single dose of Olanzapine (2 mg/kg b.w.) also significantly affects immobility time in the FST. Subsequent administration of the aforementioned drug sequence in mice statistically significantly increases the duration of immobility in comparison to the time determined in the control group in the FST. It decreased locomotor activity as well. In contrast, the results obtained in subchronic treatment after fifteen administrations of both drugs (Pitolisant 10 mg/kg b.w., and after 30 min Olanzapine 2 mg/kg b.w., and again after 4 h Olanzapine 2 mg/kg b.w.) show that the administration of Pitolisant followed by that of Olanzapine equalized the locomotor activity in mice; in comparison to the level of motility in the control group, to which only Pitolisant is administered. More importantly, this combination of drugs significantly reduces immobility time to the level obtained in the control group in the forced swim test in mice [one-way ANOVA; F (3,20)=4.226,P=0.0181][2]. Rats given Pitolisant (10 mg/kg) during the conditioning phase stayed 502±94 s on the paired texture, a value not statistically different from that of controls, indicating that Pitolisant did not support place preference[3].

References[1] Ligneau X, et al. BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J Pharmacol Exp Ther. 2007 Jan;320(1):365-75. DOI:10.1124/jpet.106.111039
[2] Dudek M, et al. H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice. Metab Brain Dis. 2016 Oct;31(5):1023-9. DOI:10.1007/s11011-016-9840-z
[3] Uguen M, et al. Preclinical evaluation of the abuse potential of Pitolisant, a histamine H receptor inverse agonist/antagonist compared with Modafinil. Br J Pharmacol. 2013 Jun;169(3):632-44. DOI:10.1111/bph.12149
Tiprolisant oxalate Preparation Products And Raw materials
Tag:Tiprolisant oxalate(362665-57-4) Related Product Information
SODIUM BINOXALATE 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidinehydrochloride 2,3,4,5-tetrahydrobenzo[b]oxepin-4-amine Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-